| Identification |
|---|
| HMDB Protein ID
| CDBP03409 |
| Secondary Accession Numbers
| Not Available |
| Name
| Chloride intracellular channel protein 6 |
| Description
| Not Available |
| Synonyms
|
- Parchorin
|
| Gene Name
| CLIC6 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated chloride channel activity |
| Specific Function
| May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| voltage-gated chloride channel activity |
| anion channel activity |
| chloride channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| Process |
| establishment of localization |
| transport |
| chloride transport |
| anion transport |
| inorganic anion transport |
| ion transport |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Single-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 21q22.12 |
| SNPs
| CLIC6 |
| Gene Sequence
|
>2115 bp
ATGGCCGAGGCCGCGGAGCCGGAGGGGGTTGCCCCGGGTCCCCAGGGGCCGCCGGAGGTC
CCCGCGCCTCTGGCTGAGAGACCCGGAGAGCCAGGAGCCGCGGGCGGGGAGGCAGAAGGG
CCGGAGGGGAGCGAGGGCGCAGAGGAGGCGCCGAGGGGCGCCGCCGCTGTGAAGGAGGCA
GGAGGCGGCGGGCCAGACAGGGGCCCGGAGGCCGAGGCGCGGGGCACGAGGGGGGCGCAC
GGCGAGACTGAGGCCGAGGAGGGAGCCCCGGAGGGTGCCGAGGTGCCCCAAGGAGGGGAG
GAGACAAGCGGCGCGCAGCAGGTGGAGGGGGCGAGCCCGGGACGCGGCGCGCAGGGCGAG
CCCCGCGGGGAGGCTCAGAGGGAGCCCGAGGACTCTGCGGCCCCCGAGAGGCAGGAGGAG
GCGGAGCAGAGGCCTGAGGTCCCGGAAGGTAGCGCGTCCGGGGAGGCGGGGGACAGCGTA
GACGCGGAGGGCCCGCTGGGGGACAACATAGAAGCGGAGGGCCCGGCGGGCGACAGCGTA
GAGGCGGAGGGCCGGGTGGGGGACAGCGTAGACGCGGAAGGTCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCCGCTGGGGGACAACATACAAGCCGAGGGCCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCGGGTGGGGGACAGCGTAGACGCGGAAGGTCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCGGGTGGGGGACAGCGTAGAGGCGGGGGACCCGGCGGGGGACGGCGTA
GAAGCGGGGGTCCCGGCGGGGGACAGCGTAGAAGCCGAAGGCCCGGCGGGGGACAGCATG
GACGCCGAGGGTCCGGCAGGAAGGGCGCGCCGGGTCTCGGGTGAGCCGCAGCAATCGGGG
GACGGCAGCCTCTCGCCCCAGGCCGAGGCAATTGAGGTCGCAGCCGGGGAGAGTGCGGGG
CGCAGCCCCGGTGAGCTCGCCTGGGACGCAGCGGAGGAGGCGGAGGTCCCGGGGGTAAAG
GGGTCCGAAGAAGCGGCCCCCGGGGACGCAAGGGCAGACGCTGGCGAGGACAGGGTAGGG
GATGGGCCACAGCAGGAGCCGGGGGAGGACGAAGAGAGACGAGAGCGGAGCCCGGAGGGG
CCAAGGGAGGAGGAAGCAGCGGGGGGCGAAGAGGAATCCCCCGACAGCAGCCCACATGGG
GAGGCCTCCAGGGGCGCCGCGGAGCCTGAGGCCCAGCTCAGCAACCACCTGGCCGAGGAG
GGCCCCGCCGAGGGTAGCGGCGAGGCCGCGCGCGTGAACGGCCGCCGGGAGGACGGAGAG
GCGTCCGAGCCCCGGGCCCTGGGGCAGGAGCACGACATCACCCTCTTCGTCAAGGTAAAA
CTTACTGCATTAGGCTGTTCTCGCATTGCTATAAAGAAATACCTGAGAGCTGGTTATGAT
GGTGAGAGTATCGGAAATTGCCCGTTTTCTCAGCGTCTCTTTATGATTCTCTGGCTGAAA
GGCGTTATATTTAATGTGACCACAGTGGACCTGAAAAGGAAACCCGCAGACCTGCAGAAC
CTGGCTCCCGGAACAAACCCTCCTTTCATGACTTTTGATGGTGAAGTCAAGACGGATGTG
AATAAGATCGAGGAGTTCTTAGAGGAGAAATTAGCTCCCCCGAGGTATCCCAAGCTGGGG
ACCCAACATCCCGAATCTAATTCCGCAGGAAATGACGTGTTTGCCAAATTCTCAGCGTTT
ATAAAAAACACGAAGAAGGATGCAAATGAGATTCATGAAAAGAACCTGCTGAAGGCCCTG
AGGAAGCTGGATAATTACTTAAATAGCCCTCTGCCTGATGAAATAGATGCCTACAGCACC
GAGGATGTCACTGTTTCTGGAAGGAAGTTTCTGGATGGGGACGAGCTGACGCTGGCTGAC
TGCAACCTCTTACCCAAGCTCCATATTATTAAGATTGTGGCCAAGAAGTACAGAGATTTT
GAATTTCCTTCTGAAATGACTGGCATCTGGAGATACTTGAATAATGCTTATGCTAGAGAT
GAGTTCACAAATACGTGTCCAGCTGATCAAGAGATTGAACACGCATATTCAGATGTTGCA
AAAAGAATGAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 704 |
| Molecular Weight
| 73010.9 |
| Theoretical pI
| 4.01 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Chloride intracellular channel protein 6
MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEA
GGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGE
PRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSV
EAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSV
DAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSG
DGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVG
DGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEE
GPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYD
GESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDV
NKIEEFLEEKLAPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKAL
RKLDNYLNSPLPDEIDAYSTEDVTVSGRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDF
EFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVAKRMK
|
| External Links |
|---|
| GenBank ID Protein
| 25990944 |
| UniProtKB/Swiss-Prot ID
| Q96NY7 |
| UniProtKB/Swiss-Prot Entry Name
| CLIC6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF448439 |
| GeneCard ID
| CLIC6 |
| GenAtlas ID
| CLIC6 |
| HGNC ID
| HGNC:2065 |
| References |
|---|
| General References
| Not Available |