| Identification |
|---|
| HMDB Protein ID
| CDBP03407 |
| Secondary Accession Numbers
| Not Available |
| Name
| Chloride intracellular channel protein 4 |
| Description
| Not Available |
| Synonyms
|
- Intracellular chloride ion channel protein p64H1
|
| Gene Name
| CLIC4 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated chloride channel activity |
| Specific Function
| Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis) |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| voltage-gated chloride channel activity |
| anion channel activity |
| chloride channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| Process |
| transport |
| chloride transport |
| anion transport |
| inorganic anion transport |
| ion transport |
| establishment of localization |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Mitochondrion
- cytoskeleton
- centrosome
- Cell junction
- Nucleus matrix
- Cytoplasmic vesicle membrane
- Single-pass membrane protein (Probable)
- Single-pass membrane protein (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36.11 |
| SNPs
| CLIC4 |
| Gene Sequence
|
>762 bp
ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAG
CTCTTCGTCAAGGCTGGCAGTGATGGTGAAAGCATAGGAAACTGCCCCTTTTCCCAGAGG
CTCTTCATGATTCTTTGGCTCAAAGGAGTTGTATTTAGTGTGACGACTGTTGACCTGAAA
AGGAAGCCAGCAGACCTGCAGAACTTGGCTCCCGGGACCCACCCACCATTTATAACTTTC
AACAGTGAAGTCAAAACGGATGTAAATAAGATTGAGGAATTTCTTGAAGAAGTCTTATGC
CCTCCCAAGTACTTAAAGCTTTCACCAAAACACCCAGAATCAAATACTGCTGGAATGGAC
ATCTTTGCCAAATTCTCTGCATATATCAAGAATTCAAGCGCAGAGGCTAATGAAGCACTG
GAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATATCTGAATTCTCCTCTCCCT
GATGAAATTGATGAAAATAGTATGGAGGACATAAAGTTTTCTACACGTAAATTTCTGGAT
GGCAATGAAATGACATTAGCTGATTGCAACCTGCTGCCCAAACTGCATATTGTCAAGGTG
GTGGCCAAAAAATATCGCAACTTTGATATTCCAAAAGAAATGACTGGCATCTGGAGATAC
CTAACTAATGCATACAGTAGGGACGAGTTCACCAATACCTGTCCCAGTGATAAGGAGGTT
GAAATAGCATATAGTGATGTAGCCAAAAGACTCACCAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 253 |
| Molecular Weight
| 28771.8 |
| Theoretical pI
| 5.26 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Chloride intracellular channel protein 4
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLK
RKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMD
IFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLD
GNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV
EIAYSDVAKRLTK
|
| External Links |
|---|
| GenBank ID Protein
| 5052202 |
| UniProtKB/Swiss-Prot ID
| Q9Y696 |
| UniProtKB/Swiss-Prot Entry Name
| CLIC4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF097330 |
| GeneCard ID
| CLIC4 |
| GenAtlas ID
| CLIC4 |
| HGNC ID
| HGNC:13518 |
| References |
|---|
| General References
| Not Available |