| Identification |
|---|
| HMDB Protein ID
| CDBP03405 |
| Secondary Accession Numbers
| Not Available |
| Name
| Chloride intracellular channel protein 2 |
| Description
| Not Available |
| Synonyms
|
- XAP121
|
| Gene Name
| CLIC2 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx |
| GO Classification
|
| Component |
| cell part |
| membrane |
| Function |
| voltage-gated chloride channel activity |
| catalytic activity |
| electron carrier activity |
| anion channel activity |
| chloride channel activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| disulfide oxidoreductase activity |
| protein disulfide oxidoreductase activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| oxidoreductase activity |
| transporter activity |
| ion channel activity |
| Process |
| cellular process |
| transport |
| chloride transport |
| anion transport |
| inorganic anion transport |
| cellular homeostasis |
| cell redox homeostasis |
| ion transport |
| establishment of localization |
|
| Cellular Location
|
- Cytoplasm
- Membrane
- Single-pass membrane protein (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Gastric Acid Production |    | Not Available | | Esomeprazole Action Pathway |    | Not Available | | Omeprazole Action Pathway |    | Not Available | | Lansoprazole Action Pathway |    | Not Available | | Pantoprazole Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| CLIC2 |
| Gene Sequence
|
>744 bp
ATGTCAGGCCTGCGGCCCGGCACTCAAGTGGACCCTGAGATTGAGCTTTTTGTAAAGGCT
GGAAGTGATGGAGAGAGTATTGGAAACTGTCCCTTTTGCCAACGCCTTTTCATGATCCTC
TGGCTTAAAGGAGTTAAATTTAATGTGACAACTGTTGACATGACCAGAAAGCCTGAAGAA
CTAAAGGACTTAGCCCCAGGTACCAATCCTCCGTTCCTGGTGTATAACAAGGAGTTGAAA
ACAGACTTCATTAAAATTGAGGAGTTTTTAGAACAAACCCTGGCTCCTCCAAGGTACCCT
CACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTT
TCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTC
AAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTGGATGAAATTGATCCA
GACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACA
CTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATAT
CGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTAT
GCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCA
AATGTGGCTAAACAGAAGAGTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 247 |
| Molecular Weight
| 28356.1 |
| Theoretical pI
| 5.26 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Chloride intracellular channel protein 2
MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEE
LKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKF
SAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLT
LADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYA
NVAKQKS
|
| External Links |
|---|
| GenBank ID Protein
| 66346733 |
| UniProtKB/Swiss-Prot ID
| O15247 |
| UniProtKB/Swiss-Prot Entry Name
| CLIC2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001289.4 |
| GeneCard ID
| CLIC2 |
| GenAtlas ID
| CLIC2 |
| HGNC ID
| HGNC:2063 |
| References |
|---|
| General References
| Not Available |