Showing Protein Atrial natriuretic peptide receptor 3 (CDBP03392)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03392
Secondary Accession Numbers Not Available
Name Atrial natriuretic peptide receptor 3
Description Not Available
Synonyms
  1. ANP-C
  2. ANPR-C
  3. Atrial natriuretic peptide clearance receptor
  4. Atrial natriuretic peptide receptor type C
  5. NPR-C
Gene Name NPR3
Protein Type Receptor
Biological Properties
General Function Involved in peptide receptor activity, G-protein coupled
Specific Function Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity
GO Classification
Component
membrane
cell part
Function
receptor activity
molecular transducer activity
signal transducer activity
peptide receptor activity
peptide receptor activity, g-protein coupled
Cellular Location
  1. Membrane
  2. Single-pass type I membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:5
Locus 5p14-p13
SNPs NPR3
Gene Sequence 
>1623 bp
ATGCCGTCTCTGCTGGTGCTCACTTTCTCCCCGTGCGTACTACTCGGCTGGGCGTTGCTG
GCCGGCGGCACCGGTGGCGGTGGCGTTGGCGGCGGCGGCGGTGGCGCGGGCATAGGCGGC
GGACGCCAGGAGAGAGAGGCGCTGCCGCCACAGAAGATCGAGGTGCTGGTGTTACTGCCC
CAGGATGACTCGTACTTGTTTTCACTCACCCGGGTGCGGCCGGCCATCGAGTATGCTCTG
CGCAGCGTGGAGGGCAACGGGACTGGGAGGCGGCTTCTGCCGCCGGGCACTCGCTTCCAG
GTGGCTTACGAGGATTCAGACTGTGGGAACCGTGCGCTCTTCAGCTTGGTGGACCGCGTG
GCGGCGGCGCGGGGCGCCAAGCCAGACCTTATCCTGGGGCCAGTGTGCGAGTATGCAGCA
GCGCCAGTGGCCCGGCTTGCATCGCACTGGGACCTGCCCATGCTGTCGGCTGGGGCGCTG
GCCGCTGGCTTCCAGCACAAGGACTCTGAGTACTCGCACCTCACGCGCGTGGCGCCCGCC
TACGCCAAGATGGGCGAGATGATGCTCGCCCTGTTCCGCCACCACCACTGGAGCCGCGCT
GCACTGGTCTACAGCGACGACAAGCTGGAGCGGAACTGCTACTTCACCCTCGAGGGGGTC
CACGAGGTCTTCCAGGAGGAGGGTTTGCACACGTCCATCTACAGTTTCGACGAGACCAAA
GACTTGGATCTGGAAGACATCGTGCGCAATATCCAGGCCAGTGAGAGAGTGGTGATCATG
TGTGCGAGCAGTGACACCATCCGGAGCATCATGCTGGTGGCGCACAGGCATGGCATGACC
AGTGGAGACTACGCCTTCTTCAACATTGAGCTCTTCAACAGCTCTTCCTATGGAGATGGC
TCATGGAAGAGAGGAGACAAACACGACTTTGAAGCTAAGCAAGCATACTCGTCCCTCCAG
ACAGTCACTCTACTGAGGACAGTGAAACCTGAGTTTGAGAAGTTTTCCATGGAGGTGAAA
AGTTCAGTTGAGAAACAAGGGCTCAATATGGAGGATTACGTTAACATGTTTGTTGAAGGA
TTCCACGATGCCATCCTCCTCTACGTCTTGGCTCTACATGAAGTACTCAGAGCTGGTTAC
AGCAAAAAGGATGGAGGGAAAATTATACAGCAGACTTGGAACAGAACATTTGAAGGTATC
GCCGGGCAGGTGTCCATAGATGCCAACGGAGACCGATATGGGGATTTCTCTGTGATTGCC
ATGACTGATGTGGAGGCGGGCACCCAGGAGGTTATTGGTGATTATTTTGGAAAAGAAGGT
CGTTTTGAAATGCGGCCGAATGTCAAATATCCTTGGGGCCCTTTAAAACTGAGAATAGAT
GAAAACCGAATTGTAGAGCATACAAACAGCTCTCCCTGCAAATCATGTGGCCTAGAAGAA
TCGGCAGTGACAGGAATTGTCGTGGGGGCTTTACTAGGAGCTGGCTTGCTAATGGCCTTC
TACTTTTTCAGGAAGAAATACAGAATAACCATTGAGAGGCGAACCCAGCAAGAAGAAAGT
AACCTTGGAAAACATCGGGAATTACGGGAAGATTCCATCAGATCCCATTTTTCAGTAGCT
TAA
Protein Properties
Number of Residues 541
Molecular Weight 59807.3
Theoretical pI 6.31
Pfam Domain Function
Signals
  • ["1-26"]
Transmembrane Regions
  • ["482-504"]
Protein Sequence 
>Atrial natriuretic peptide receptor 3
MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLP
QDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRV
AAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPA
YAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETK
DLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDG
SWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEG
FHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIA
MTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLE
ESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRTQQEESNLGKHRELREDSIRSHFSV
A
GenBank ID Protein 28706
UniProtKB/Swiss-Prot ID P17342
UniProtKB/Swiss-Prot Entry Name ANPRC_HUMAN
PDB IDs
GenBank Gene ID X52282
GeneCard ID NPR3
GenAtlas ID NPR3
HGNC ID HGNC:7945
References
General References Not Available