| Identification |
|---|
| HMDB Protein ID
| CDBP03390 |
| Secondary Accession Numbers
| Not Available |
| Name
| Transmembrane protein 132A |
| Description
| Not Available |
| Synonyms
|
- HSPA5-binding protein 1
|
| Gene Name
| TMEM132A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Single-pass type I membrane protein
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q12.2 |
| SNPs
| TMEM132A |
| Gene Sequence
|
>3072 bp
ATGTGCGCGCGGATGGCCGGTCGCACAACAGCGGCCCCTCGGGGGCCCTACGGCCCCTGG
CTCTGCCTCCTGGTGGCCCTCGCCCTGGACGTCGTGAGAGTGGACTGTGGCCAGGCTCCC
CTGGACCCTGTCTACCTGCCGGCAGCCCTGGAGCTCCTAGACGCCCCTGAACACTTCCGT
GTGCAGCAGGTGGGCCACTACCCACCTGCCAACTCCTCTCTGAGCTCCCGATCTGAGACC
TTTCTGCTCCTACAGCCCTGGCCCAGGGCCCAGCCACTTCTCCGGGCCTCCTACCCACCT
TTTGCCACTCAGCAGGTGGTCCCCCCTCGAGTCACTGAGCCCCACCAACGGCCAGTCCCA
TGGGACGTGCGGGCCGTTTCAGTGGAAGCGGCTGTGACTCCAGCAGAGCCCTACGCCCGG
GTTCTCTTCCACCTCAAAGGGCAGGATTGGCCACCAGGGTCTGGCAGCCTGCCCTGTGCC
CGGCTCCATGCCACACACCCTGCCGGCACTGCTCACCAAGCCTGCCGCTTCCAGCCATCC
CTGGGCGCCTGCGTGGTGGAGCTGGAGCTTCCCTCGCACTGGTTCTCACAGGCCTCCACC
ACACGGGCCGAGCTGGCCTACACGCTTGAGCCTGCAGCTGAGGGCCCTGGGGGCTGTGGC
TCCGGCGAGGAGAACGACCCTGGGGAGCAGGCCCTCCCAGTGGGGGGTGTGGAGCTGCGC
CCAGCAGACCCCCCGCAGTACCAGGAGGTACCTCTGGACGAGGCTGTGACTCTGCGGGTG
CCTGACATGCCAGTGCGGCCCGGCCAGCTCTTTAGTGCTACCCTCCTGCTTCGGCACAAC
TTCACAGCCAGCCTCCTGACCCTGCGGATCAAGGTGAAGAAGGGGCTGCATGTGACAGCC
GCCCGCCCAGCCCAGCCCACACTCTGGACTGCCAAGCTGGACCGCTTCAAGGGCTCCAGG
CACCACACCACCCTCATCACCTGCCACCGTGCTGGGCTCACAGAGCCAGATTCCAGTCCC
CTTGAACTGTCTGAGTTCCTATGGGTGGACTTTGTGGTGGAGAATAGCACTGGTGGGGGC
GTAGCGGTCACTCGCCCCGTCACGTGGCAGCTGGAGTACCCAGGCCAGGCCCCTGAAGCA
GAGAAGGACAAAATGGTGTGGGAAATCCTGGTGTCTGAGCGGGACATCAGAGCCCTTATC
CCACTGGCCAAGGCTGAGGAGCTGGTGAATACAGCACCACTGACTGGAGTGCCCCAGCAT
GTCCCCGTGCGCCTTGTCACTGTGGACGGCGGGGGGGCCTTGGTGGAGGTGACAGAGCAT
GTCGGCTGCGAGTCTGCCAACACACAGGTCCTGCAGGTGTCTGAGGCCTGTGATGCCGTG
TTCGTGGCTGGCAAGGAGAGCCGGGGCGCCCGGGGGGTGCGAGTGGACTTCTGGTGGCGC
CGGCTCCGCGCCTCGCTGCGGCTGACCGTGTGGGCCCCCCTGCTACCGCTGCGTATCGAG
CTCACCGACACCACCCTCGAGCAGGTCCGCGGCTGGAGGGTACCTGGCCCTGCTGAAGGG
CCTGCGGAACCCGCTGCAGAGGCGTCGGATGAGGCCGAGCGGCGCGCCCGTGGCTGCCAC
CTGCAGTACCAGCGGGCCGGTGTGCGCTTCCTCGCCCCCTTCGCGGCCCACCCGCTGGAC
GGCGGCCGCCGCCTCACGCACCTGCTTGGCCCCGACTGGCTGCTAGACGTGTCCCACCTC
GTGGCGCCACACGCCCGCGTGCTGGACTCGCGTGTAGCCTCTCTGGAGGGTGGCCGTGTC
GTGGTGGGCCGGGAGCCCGGTGTCACCTCCATTGAGGTGCGTTCCCCACTGTCTGACTCC
ATCCTGGGGGAGCAGGCGCTGGCTGTGACGGACGACAAGGTCTCAGTGCTGGAGCTGAGG
GTGCAGCCAGTGATGGGCATCTCGCTGACCTTGAGCCGGGGCACTGCCCACCCCGGGGAG
GTCACAGCTACGTGCTGGGCACAGTCAGCCCTTCCCGCCCCAAAGCAGGAGGTGGCCCTC
TCCCTATGGCTGTCCTTCTCTGATCACACTGTGGCCCCAGCTGAGCTCTACGACCGCCGT
GACCTGGGACTGTCCGTCTCAGCCGAGGAGCCTGGTGCCATCCTGCCAGCTGAGGAGCAG
GGTGCCCAGCTCGGGGTGGTGGTGAGTGGGGCAGGCGCCGAGGGGCTGCCGCTGCATGTG
GCTCTGCACCCGCCCGAGCCCTGCCGCCGGGGCCGCCACCGTGTGCCTCTGGCCTCTGGC
ACCGCCTGGCTGGGGCTGCCCCCTGCCTCCACTCCAGCCCCTGCTCTCCCATCCAGCCCT
GCTTGGAGCCCACCAGCCACAGAAGCCACCATGGGTGGTAAACGGCAGGTGGCAGGCAGT
GTCGGGGGCAACACAGGTGTGAGGGGCAAGTTTGAGCGGGCAGAGGAGGAGGCCAGGAAG
GAGGAGACCGAAGCCAGGGAGGAGGAGGAGGAAGAGGAGGAGGAGATGGTCCCTGCCCCT
CAGCATGTCACTGAGCTAGAGCTGGGCATGTACGCCCTGCTGGGAGTCTTCTGCGTGGCC
ATCTTCATCTTCTTGGTCAATGGTGTGGTCTTCGTCCTGCGCTATCAGCGCAAAGAACCT
CCCGACAGTGCCACTGACCCCACCTCCCCCCAGCCCCACAACTGGGTCTGGCTGGGCACT
GACCAGGAGGAACTGAGCCGCCAGCTGGACCGGCAGTCCCCTGGCCCGCCCAAGGGGGAG
GGGAGCTGCCCCTGTGAGAGTGGGGGAGGAGGGGAGGCCCCTACCCTGGCCCCTGGCCCT
CCTGGGGGCACCACCAGCTCCTCAAGCACCCTGGCCCGAAAGGAGGCTGGGGGGCGGCGG
AAGCGAGTAGAGTTTGTGACATTTGCGCCAGCCCCTCCAGCCCAGTCACCTGAGGAGCCT
GTAGGGGCCCCTGCTGTGCAGTCCATCCTTGTGGCAGGCGAGGAGGACATCCGCTGGGTG
TGTGAGGACATGGGGCTGAAGGACCCTGAGGAGCTTCGCAACTACATGGAGAGGATCCGG
GGCAGCTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1023 |
| Molecular Weight
| 110108.9 |
| Theoretical pI
| 5.36 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Transmembrane protein 132A
MCARMAGRTTAAPRGPYGPWLCLLVALALDVVRVDCGQAPLDPVYLPAALELLDAPEHFR
VQQVGHYPPANSSLSSRSETFLLLQPWPRAQPLLRASYPPFATQQVVPPRVTEPHQRPVP
WDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGSGSLPCARLHATHPAGTAHQACRFQPS
LGACVVELELPSHWFSQASTTRAELAYTLEPAAEGPGGCGSGEENDPGEQALPVGGVELR
PADPPQYQEVPLDEAVTLRVPDMPVRPGQLFSATLLLRHNFTASLLTLRIKVKKGLHVTA
ARPAQPTLWTAKLDRFKGSRHHTTLITCHRAGLTEPDSSPLELSEFLWVDFVVENSTGGG
VAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERDIRALIPLAKAEELVNTAPLTGVPQH
VPVRLVTVDGGGALVEVTEHVGCESANTQVLQVSEACDAVFVAGKESRGARGVRVDFWWR
RLRASLRLTVWAPLLPLRIELTDTTLEQVRGWRVPGPAEGPAEPAAEASDEAERRARGCH
LQYQRAGVRFLAPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAPHARVLDSRVASLEGGRV
VVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPVMGISLTLSRGTAHPGE
VTATCWAQSALPAPKQEVALSLWLSFSDHTVAPAELYDRRDLGLSVSAEEPGAILPAEEQ
GAQLGVVVSGAGAEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPASTPAPALPSSP
AWSPPATEATMGGKRQVAGSVGGNTGVRGKFERAEEEARKEETEAREEEEEEEEEMVPAP
QHVTELELGMYALLGVFCVAIFIFLVNGVVFVLRYQRKEPPDSATDPTSPQPHNWVWLGT
DQEELSRQLDRQSPGPPKGEGSCPCESGGGGEAPTLAPGPPGGTTSSSSTLARKEAGGRR
KRVEFVTFAPAPPAQSPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIR
GSS
|
| External Links |
|---|
| GenBank ID Protein
| 30089937 |
| UniProtKB/Swiss-Prot ID
| Q24JP5 |
| UniProtKB/Swiss-Prot Entry Name
| T132A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_178031.2 |
| GeneCard ID
| TMEM132A |
| GenAtlas ID
| TMEM132A |
| HGNC ID
| HGNC:31092 |
| References |
|---|
| General References
| Not Available |