| Identification |
|---|
| HMDB Protein ID
| CDBP03388 |
| Secondary Accession Numbers
| Not Available |
| Name
| A-kinase anchor protein SPHKAP |
| Description
| Not Available |
| Synonyms
|
- SPHK1-interactor and AKAP domain-containing protein
- Sphingosine kinase type 1-interacting protein
|
| Gene Name
| SPHKAP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1 |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q36 |
| SNPs
| SPHKAP |
| Gene Sequence
|
>5103 bp
ATGGATGGCAACTCCCTGCTCTCGGTACCAAGCAACTTGGAGTCATCACGGATGTATGAC
GTTTTGGAACCGCAGCAGGGCAGAGGCTGTGGCAGCTCAGGAAGCGGCCCGGGGAACTCC
ATCACAGCCTGTAAGAAGGTTCTTCGCAGCAATAGCCTGCTGGAGTCAACAGACTACTGG
TTGCAGAATCAGAGGATGCCCTGCCAAATTGGTTTTGTAGAAGACAAGTCTGAAAACTGT
GCTTCTGTCTGCTTTGTGAATCTTGATGTGAACAAGGATGAATGCAGCACAGAGCACCTG
CAACAGAAACTGGTCAACGTTTCACCAGATCTTCCAAAACTTATCAGTTCCATGAATGTC
CAACAACCAAAAGAAAATGAAATTGTTGTCCTAAGTGGGTTAGCCTCTGGAAATCTCCAG
GCAGATTTTGAAGTTTCACAGTGCCCTTGGCTGCCAGATATCTGCTTGGTCCAATGTGCA
AGAGGGAACAGACCAAACAGTACCAACTGCATCATCTTTGAAATCAACAAATTTCTGATT
GGTCTGGAACTGGTGCAGGAGCGACAGCTCCACCTGGAAACAAACATCTTGAAACTGGAG
GATGACACGAACTGTTCCTTATCTTCAATCGAGGAAGACTTTCTCACCGCTTCTGAGCAC
TTGGAGGAGGAAAGCGAGGTGGATGAATCTAGGAACGATTATGAAAATATAAATGTCTCA
GCCAATGTTTTGGAAAGTAAACAGCTAAAGGGAGCCACCCAGGTGGAATGGAATTGCAAC
AAGGAAAAGTGGCTTTATGCTTTGGAAGACAAATACATCAACAAATATCCCACACCATTG
ATTAAAACAGAACGATCTCCAGAAAACCTAACAAAGAACACAGCCTTGCAGAGTCTAGAT
CCCTCAGCCAAGCCATCACAGTGGAAAAGAGAAGCTGTGGGGAATGGGAGACAAGCCACA
CATTATTATCATTCAGAAGCTTTTAAAGGTCAAATGGAAAAATCACAGGCACTGTATATT
CCAAAAGATGCTTATTTCTCCATGATGGATAAAGATGTACCTTCTGCATGTGCTGTGGCA
GAGCAGAGAAGCAACCTAAACCCAGGAGACCATGAAGACACAAGAAACGCTCTCCCTCCT
AGACAAGATGGAGAAGTCACCACTGGCAAGTATGCTACAAATTTAGCAGAATCCGTGCTG
CAGGATGCATTTATTAGATTATCTCAATCTCAGTCCACATTACCCCAGGAATCTGCAGTC
AGTGTTTCTGTAGGAAGTTCTCTGCTTCCCAGTTGCTATTCCACAAAAGATACAGTGGTT
TCTCGGTCATGGAATGAGCTCCCCAAAATCGTCGTTGTTCAGAGTCCAGATGGCAGTGAT
GCTGCCCCACAGCCAGGCATCTCCTCCTGGCCTGAGATGGAAGTCTCTGTTGAAACCTCA
AGCATCCTCTCTGGAGAGAACTCCAGCAGACAACCCCAGAGTGCTCTAGAAGTGGCGTTA
GCTTGTGCAGCCACTGTGATTGGAACTATTTCCAGTCCACAGGCCACAGAAAGACTCAAA
ATGGAGCAAGTGGTCTCGAACTTTCCCCCAGGGAGCAGTGGTGCACTGCAAACTCAAGCA
CCCCAAGGACTCAAGGAACCTTCCATCAATGAGTACTCCTTTCCATCTGCTTTGTGTGGC
ATGACTCAGGTGGCCAGTGCCGTGGCTGTCTGTGGTCTGGGTGAAAGAGAAGAGGTGACA
TGCTCAGTGGCTCCAAGTGGTAGCCTCCCGCCTGCAGCTGAGGCTTCTGAAGCCATGCCC
CCACTTTGTGGTTTAGCAAGCATGGAGCTTGGCAAGGAAGCCATTGCCAAGGGATTGCTC
AAGGAGGCTGCTCTGGTTTTAACAAGGCCTAATACCTACAGCAGCATTGGAGACTTTCTG
GACTCCATGAACAGGAGAATCATGGAAACTGCTTCAAAGTCTCAGACCCTGTGCTCAGAA
AATGTCGTCAGGAATGAACTGGCACATACCCTGTCCAATGTTATCCTGAGGCATTCCATT
GATGAAGTTCACCACAAAAATATGATAATCGACCCCAATGACAACAGGCATTCATCTGAA
ATTCTGGACACCTTAATGGAAAGTACAAATCAACTGCTTTTAGATGTGATATGCTTCACG
TTCAAGAAGATGAGTCATATTGTACGGCTTGGTGAATGTCCTGCTGTCCTTTCTAAGGAG
ACCATCAGAAGGAGGGAGACAGAACCAAGCTGCCAGCCATCTGATCCGGGTGCTAGTCAA
GCTTGGACAAAAGCCACTGAATCCTCCAGCAGCTCTCCACTTAGCAATTCACACAACACG
AGTCTTGTCATCAACAATCTTGTGGATGGCATGTATTCAAAACAAGACAAGGGTGGAGTG
AGGCCAGGCCTCTTCAAGAACCCCACGCTGCAGTCACAATTATCACGTAGTCACAGAGTG
CCCGATTCTTCAACTGCTACAACATCCTCCAAGGAAATATATCTGAAAGGAATAGCAGGA
GAGGATACAAAAAGCCCTCATCACAGTGAGAATGAATGCAGAGCCTCTTCCGAAGGACAA
AGGTCCCCAACGGTCAGCCAGTCCAGAAGTGGTTCCCAGGAGGCTGAGGAGAGTATCCAC
CCAAACACCCAAGAAAAGTACAACTGTGCCACATCTCGCATCAACGAAGTTCAAGTCAAC
CTGTCCTTGTTAGGGGATGACCTGCTGCTTCCTGCTCAATCCACGCTTCAAACAAAGCAT
CCAGACATCTACTGCATTACAGACTTTGCGGAAGAATTAGCAGACACGGTCGTCTCCATG
GCAACTGAAATTGCAGCGATTTGCCTTGACAACTCCAGTGGAAAACAACCCTGGTTTTGT
GCATGGAAAAGAGGGAGTGAGTTTCTGATGACACCCAACGTACCCTGCCGATCCTTGAAG
AGGAAGAAAGAGAGCCAGGGGAGCGGGACCGCTGTGAGGAAACACAAGCCTCCCCGGCTC
AGTGAGATCAAGAGGAAGACGGACGAGCACCCTGAGCTTAAAGAAAAGCTGATGAACAGG
GTTGTGGATGAGTCCATGAACCTTGAAGATGTCCCAGATTCTGTCAATCTTTTTGCCAAT
GAAGTGGCAGCCAAGATCATGAACCTAACGGAGTTCTCTATGGTGGACGGCATGTGGCAG
GCGCAGGGCTATCCCCGGAATCGGTTACTGAGTGGCGACAGGTGGAGCCGGCTGAAGGCC
TCCAGCTGCGAAAGCATTCCTGAGGAAGACTCCGAGGCCAGGGCCTATGTCAACAGCCTG
GGCTTAATGAGCACGCTGAGCCAGCCGGTCAGCAGGGCCAGCTCTGTCTCCAAGCAGTCG
AGCTGTGAGAGCATCACCGATGAGTTTTCCAGGTTCATGGTGAACCAGATGGAAAATGAA
GGGAGAGGATTTGAGTTACTGCTGGATTACTATGCTGGCAAGAACGCCAGCAGCATTCTG
AACTCAGCCATGCAACAGGCGTGCCGGAAAAGTGACCACCTCAGTGTGAGGCCTAGCTGT
CCCTCTAAGCAGTCCAGCACAGAGAGCATCACTGAGGAGTTCTACAGGTACATGCTGAGG
GACATCGAAAGAGACAGCAGAGAAAGTGCCTCCTCCAGACGGAGCAGCCAGGATTGGACA
GCCGGCCTGCTGTCTCCTTCTCTGCGATCCCCAGTGTGCCACAGACAGTCGTCCATGCCA
GACAGCAGATCCCCATGCTCCAGGCTGACAGTGAATGTGCCCATCAAAGCCAACTCTTTA
GATGGCTTTGCTCAGAACTGCCCACAAGATTTCCTAAGCGTGCAGCCGGTCAGTAGCGCG
TCCTCATCCGGTCTCTGCAAATCTGACTCTTGCTTGTATCGGAGAGGTGGGACTGACCAC
ATCACCAACATGTTAATTCATGAAACGTGGGCTAGCTCCATTGAGGCTCTCATGCGCAAG
AACAAAATCATTGTGGATGATGCAGAGGAAGCTGACACTGAGCCTGTTTCTGGTGGCTCT
CCCTCGCAAGCAGAGAAGTGTGCAAATAGATTAGCTGCGAGCAGGATGTGCAGTGGGCCA
ACTCTGCTTGTTCAGGAGTCTCTCGATTGCCCGAGGAAAGACTCTGTTACCGAATGTAAA
CAGCCCCCAGTGTCATCTTTGAGCAAAACTGCTTCTCTTACAAACCACAGCCCTTTAGAT
TCTAAAAAAGAAACTTCCTCGTGCCAGGACCCTGTACCAATAAACCACAAAAGGCGATCA
CTTTGCTCGAGGGAAGTGCCTTTGATTCAGATTGAAACAGATCAGAGAGAAGCCTGTGCT
GGGGAACCTGAACCCTTCCTTTCCAAAAGCAGCCTCCTAGAGGAAGCAGAAGGGCATTCG
AATGACAAAAACATCCCAGATGTGGTGAGAGGTGGAGACACAGCCGTGAGCGCTTGTCAA
ATCCATAGTGACAGCCTTGATACCAGAGATGTACCAGAGGCTGAAGCCTCCACAGAAGCC
AGAGCCCCCGATGAGGCCCCCAACCCTCCAAGCAGCAGCGAGGAGAGCACAGGCAGCTGG
ACCCAGCTTGCCAATGAGGAAGACAACCCAGATGACACAAGTAGCTTTCTCCAGCTCAGT
GAGCGATCCATGAGCAATGGCAACAGTAGTGCCACTAGCAGTCTTGGCATTATGGATCTG
GACATTTATCAGGAAAGCATGCCATCTTCTCCCATGATTAATGAATTAGTAGAAGAAAAG
AAGATTCTTAAAGGACAGTCAGAAAGCACAGAGGCACCTGCATCTGGACCGCCTACGGGA
ACAGCCAGCCCCCAGAGGAGCCTGCTGGTGATCAACTTTGACCTGGAGCCAGAGTGTCCA
GATGCCGAGCTCCGAGCCACTCTGCAGTGGATAGCTGCCTCTGAACTGGGGATTCCCACC
ATCTACTTTAAGAAATCTCAGGAAAACAGAATTGAAAAGTTTCTAGATGTCGTGCAGCTG
GTTCATCGGAAGTCCTGGAAAGTGGGTGATATCTTCCATGCAGTTGTCCAGTACTGCAAA
ATGCATGAGGAGCAGAAGGATGGGAGACTGAGTCTCTTTGACTGGCTCTTGGAACTGGGA
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 1700 |
| Molecular Weight
| 186454.3 |
| Theoretical pI
| 4.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>A-kinase anchor protein SPHKAP
MDGNSLLSVPSNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYW
LQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNV
QQPKENEIVVLSGLASGNLQADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLI
GLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVS
ANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLD
PSAKPSQWKREAVGNGRQATHYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVA
EQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAV
SVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETS
SILSGENSSRQPQSALEVALACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQA
PQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMP
PLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSE
NVVRNELAHTLSNVILRHSIDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFT
FKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNT
SLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAG
EDTKSPHHSENECRASSEGQRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVN
LSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFC
AWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNR
VVDESMNLEDVPDSVNLFANEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKA
SSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENE
GRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLR
DIERDSRESASSRRSSQDWTAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSL
DGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRK
NKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECK
QPPVSSLSKTASLTNHSPLDSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACA
GEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEA
RAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDL
DIYQESMPSSPMINELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECP
DAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCK
MHEEQKDGRLSLFDWLLELG
|
| External Links |
|---|
| GenBank ID Protein
| 85397610 |
| UniProtKB/Swiss-Prot ID
| Q2M3C7 |
| UniProtKB/Swiss-Prot Entry Name
| SPKAP_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC104954 |
| GeneCard ID
| SPHKAP |
| GenAtlas ID
| SPHKAP |
| HGNC ID
| HGNC:30619 |
| References |
|---|
| General References
| Not Available |