| Identification |
|---|
| HMDB Protein ID
| CDBP03382 |
| Secondary Accession Numbers
| Not Available |
| Name
| Relaxin-3 receptor 2 |
| Description
| Not Available |
| Synonyms
|
- G-protein coupled receptor 100
- G-protein coupled receptor GPCR142
- Insulin-like peptide INSL5 receptor
- RLN3 receptor 2
- Relaxin family peptide receptor 4
|
| Gene Name
| RXFP4 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation |
| GO Classification
|
| Component |
| intrinsic to membrane |
| integral to membrane |
| cell part |
| membrane part |
| Function |
| receptor activity |
| angiotensin receptor activity |
| angiotensin type ii receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q22 |
| SNPs
| RXFP4 |
| Gene Sequence
|
>1125 bp
ATGCCCACACTCAATACTTCTGCCTCTCCACCCACATTCTTCTGGGCCAATGCCTCCGGA
GGCAGTGTGCTGAGTGCTGATGATGCTCCGATGCCTGTCAAATTCCTAGCCCTGAGGCTC
ATGGTTGCCCTGGCCTATGGGCTTGTGGGGGCCATTGGCTTGCTGGGAAATTTGGCGGTG
CTGTGGGTACTGAGTAACTGTGCCCGGAGAGCCCCTGGCCCACCTTCAGACACCTTCGTC
TTCAACCTGGCTCTGGCGGACCTGGGACTGGCACTCACTCTCCCCTTTTGGGCAGCCGAG
TCGGCACTGGACTTTCACTGGCCCTTCGGAGGTGCCCTCTGCAAGATGGTTCTGACGGCC
ACTGTCCTCAACGTCTATGCCAGCATCTTCCTCATCACAGCGCTGAGCGTTGCTCGCTAC
TGGGTGGTGGCCATGGCTGCGGGGCCAGGCACCCACCTCTCACTCTTCTGGGCCCGAATA
GCCACCCTGGCAGTGTGGGCGGCGGCTGCCCTGGTGACGGTGCCCACAGCTGTCTTCGGG
GTGGAGGGTGAGGTGTGTGGTGTGCGCCTTTGCCTGCTGCGTTTCCCCAGCAGGTACTGG
CTGGGGGCCTACCAGCTGCAGAGGGTGGTGCTGGCTTTCATGGTGCCCTTGGGCGTCATC
ACCACCAGCTACCTGCTGCTGCTGGCCTTCCTGCAGCGGCGGCAACGGCGGCGGCAGGAC
AGCAGGGTCGTGGCCCGCTCTGTCCGCATCCTGGTGGCTTCCTTCTTCCTCTGCTGGTTT
CCCAACCATGTGGTCACTCTCTGGGGTGTCCTGGTGAAGTTTGACCTGGTGCCCTGGAAC
AGTACTTTCTATACTATCCAGACGTATGTCTTCCCTGTCACTACTTGCTTGGCACACAGC
AATAGCTGCCTCAACCCTGTGCTGTACTGTCTCCTGAGGCGGGAGCCCCGGCAGGCTCTG
GCAGGCACCTTCAGGGATCTGCGGTTGAGGCTGTGGCCCCAGGGCGGAGGCTGGGTGCAA
CAGGTGGCCCTAAAGCAGGTAGGCAGGCGGTGGGTCGCAAGCAACCCCCGGGAGAGCCGC
CCTTCTACCCTGCTCACCAACCTGGACAGAGGGACACCCGGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 374 |
| Molecular Weight
| 41141.0 |
| Theoretical pI
| 10.65 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["44-64", "79-99", "117-137", "155-175", "210-230", "250-270", "282-302"]
|
| Protein Sequence
|
>Relaxin-3 receptor 2
MPTLNTSASPPTFFWANASGGSVLSADDAPMPVKFLALRLMVALAYGLVGAIGLLGNLAV
LWVLSNCARRAPGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGGALCKMVLTA
TVLNVYASIFLITALSVARYWVVAMAAGPGTHLSLFWARIATLAVWAAAALVTVPTAVFG
VEGEVCGVRLCLLRFPSRYWLGAYQLQRVVLAFMVPLGVITTSYLLLLAFLQRRQRRRQD
SRVVARSVRILVASFFLCWFPNHVVTLWGVLVKFDLVPWNSTFYTIQTYVFPVTTCLAHS
NSCLNPVLYCLLRREPRQALAGTFRDLRLRLWPQGGGWVQQVALKQVGRRWVASNPRESR
PSTLLTNLDRGTPG
|
| External Links |
|---|
| GenBank ID Protein
| 20152250 |
| UniProtKB/Swiss-Prot ID
| Q8TDU9 |
| UniProtKB/Swiss-Prot Entry Name
| RL3R2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB083593 |
| GeneCard ID
| RXFP4 |
| GenAtlas ID
| RXFP4 |
| HGNC ID
| HGNC:14666 |
| References |
|---|
| General References
| Not Available |