| Identification |
|---|
| HMDB Protein ID
| CDBP03380 |
| Secondary Accession Numbers
| Not Available |
| Name
| Synembryn-B |
| Description
| Not Available |
| Synonyms
|
- Brain synembrin
- Protein Ric-8B
- hSyn
|
| Gene Name
| RIC8B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha- dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction |
| GO Classification
|
|
| Cellular Location
|
- Cytoplasm
- cell cortex
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q23.3 |
| SNPs
| RIC8B |
| Gene Sequence
|
>1563 bp
ATGGATGAGGAGCGCGCCCTCTACATCGTCCGGGCCGGCGAAGCAGGGGCTATCGAGCGG
GTCCTGAGGGATTACAGCGACAAGCATAGGGCTACTTTCAAATTTGAATCAACAGATGAA
GATAAAAGAAAGAAACTCTGTGAAGGCATATTTAAAGTCCTTATAAAGGACATCCCAACA
ACATGTCAAGTGTCCTGCCTGGAAGTACTCCGCATTCTCTCCAGAGACAAAAAGGTTTTA
GTTCCTGTGACAACTAAGGAAAATATGCAGATACTGCTGCGACTAGCCAAGCTAAATGAG
TTAGATGATTCTTTGGAGAAAGTATCAGAGTTCCCAGTTATTGTGGAGTCATTAAAATGT
CTGTGTAATATAGTGTTCAACAGTCAGATGGCACAGCAGCTCAGCCTGGAACTTAATCTT
GCTGCAAAGCTCTGTAACCTCCTGAGAAAGTGCAAGGACCGGAAATTTATCAATGACATT
AAGTGCTTTGACTTGCGCTTGCTCTTCCTTCTGTCACTTTTGCACACCGACATCAGGTCA
CAATTGCGCTATGAGCTCCAGGGACTACCGCTGCTAACGCAGATCTTGGAAAGTGCCTTT
AGCATCAAGTGGACCGATGAGTATGAATCGGCCATAGACCATAATGGACCTCCTCTCTCA
CCTCAGGAGACAGACTGTGCCATTGAGGCCCTCAAAGCTCTCTTCAATGTGACGGTAGAC
AGTTGGAAGGTGCATAAAGAGAGTGATTCTCATCAGTTCCGTGTAATGGCAGCTGTCCTT
CGTCATTGTTTACTAATCGTAGGTCCAACTGAAGACAAAACAGAAGAGCTACACAGCAAT
GCAGTCAACCTTTTAAGCAATGTTCCAGTCTCTTGTTTGGATGTTCTCATTTGTCCGTTA
ACCCATGAAGAAACAGCCCAAGAGGCAACGACTCTAGATGAACTGCCCAGTAATAAAACA
GCTGAGAAAGAAACAGTTTTGAAAAACAATACCATGGTATACAATGGTATGAATATGGAG
GCCATTCATGTTTTACTGAATTTTATGGAGAAGAGAATAGACAAGGGAAGCAGCTATAGA
GAGGGTCTAACTCCAGTTCTCAGCTTATTAACCGAATGTTCCCGAGCCCATCGAAACATC
CGAAAATTTCTCAAAGATCAGGTTTTACCACCGTTGAGGGATGTGACAAATCGACCTGAA
GTTGGCTCAACTGTGAGAAATAAGCTGGTGCGCCTCATGACACATGTTGACCTTGGAGTC
AAGCAAATTGCTGCTGAATTCCTTTTTGTCCTTTGCAAAGAGAGAGTGGATAGTCTGCTG
AAATACACTGGCTATGGGAATGCTGCAGGACTGTTGGCGGCCAGGGGCCTCTTGGCTGGA
GGAAGAGGAGATAATTGGTACTCAGAGGATGAGGACACAGACACTGAAGAATACAAAAAT
GCAAAACCAAAAGAGGAGTTGCTTAAACCAATGGGACTAAAACCTGATGGGACAATAACG
CCTTTGGAGGAAGCACTCAACCAGTACTCTGTCATCGAAGAGACCAGCTCTGACACAGAC
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 520 |
| Molecular Weight
| 58824.1 |
| Theoretical pI
| 5.45 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Synembryn-B
MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT
TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC
LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS
QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD
SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL
THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR
EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV
KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN
AKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD
|
| External Links |
|---|
| GenBank ID Protein
| 124375842 |
| UniProtKB/Swiss-Prot ID
| Q9NVN3 |
| UniProtKB/Swiss-Prot Entry Name
| RIC8B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC132689 |
| GeneCard ID
| RIC8B |
| GenAtlas ID
| RIC8B |
| HGNC ID
| HGNC:25555 |
| References |
|---|
| General References
| Not Available |