| Identification |
|---|
| HMDB Protein ID
| CDBP03379 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rhophilin-2 |
| Description
| Not Available |
| Synonyms
|
- 76 kDa RhoB effector protein
- GTP-Rho-binding protein 2
- p76RBE
|
| Gene Name
| RHPN2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in signal transduction |
| Specific Function
| Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| binding |
| protein binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
|
| Cellular Location
|
- Cytoplasm
- perinuclear region
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.11 |
| SNPs
| RHPN2 |
| Gene Sequence
|
>2061 bp
ATGACCGACGCGCTGTTGCCCGCGGCCCCCCAGCCGCTGGAGAAGGAGAACGACGGCTAC
TTTCGGAAGGGCTGTAATCCCCTTGCACAAACCGGCCGGAGTAAATTGCAGAATCAAAGA
GCTGCTTTGAATCAGCAGATCCTGAAAGCCGTGCGGATGAGGACCGGAGCGGAAAACCTT
CTGAAAGTGGCCACAAACTCAAAGGTGCGGGAGCAAGTGCGGCTGGAGCTGAGCTTCGTC
AACTCAGACCTGCAGATGCTCAAGGAAGAGCTGGAGGGGCTGAACATCTCGGTGGGCGTC
TATCAGAACACAGAGGAGGCATTTACGATTCCCCTGATTCCTCTTGGCCTGAAGGAAACG
AAAGACGTCGACTTTGCAGTCGTCCTCAAGGATTTTATCCTGGAACATTACAGTGAAGAT
GGCTATTTATATGAAGATGAAATTGCAGATCTTATGGATCTGAGACAAGCTTGTCGGACG
CCTAGCCGGGATGAGGCCGGGGTGGAACTGCTGATGACATACTTCATCCAGCTGGGCTTT
GTCGAGAGTCGATTCTTCCCGCCCACACGGCAGATGGGACTCCTGTTCACCTGGTATGAC
TCTCTCACCGGGGTTCCGGTCAGCCAGCAGAACCTGCTGCTGGAGAAGGCCAGTGTCCTG
TTCAACACTGGGGCCCTCTACACCCAGATTGGGACCCGGTGTGATCGGCAGACGCAGGCT
GGGCTGGAGAGTGCCATAGATGCCTTTCAGAGAGCCGCAGGGGTTTTAAATTACCTGAAA
GACACATTTACCCATACTCCAAGTTACGACATGAGCCCTGCCATGCTCAGCGTGCTCGTC
AAAATGATGCTTGCACAAGCCCAAGAAAGCGTGTTTGAGAAAATCAGCCTTCCTGGGATC
CGGAATGAATTCTTCATGCTGGTGAAGGTGGCTCAGGAGGCTGCTAAGGTGGGAGAGGTC
TACCAACAGCTACACGCAGCCATGAGCCAGGCGCCGGTGAAAGAGAACATCCCCTACTCC
TGGGCCAGCTTAGCCTGCGTGAAGGCCCACCACTACGCGGCCCTGGCCCACTACTTCACT
GCCATCCTCCTCATCGACCACCAGGTGAAGCCAGGCACGGATCTGGACCACCAGGAGAAG
TGCCTGTCCCAGCTCTACGACCACATGCCAGAGGGGCTGACACCCTTGGCCACACTGAAG
AATGATCAGCAGCGCCGACAGCTGGGGAAGTCCCACTTGCGCAGAGCCATGGCTCATCAC
GAGGAGTCGGTGCGGGAGGCCAGCCTCTGCAAGAAGCTGCGGAGCATTGAGGTGCTACAG
AAGGTGCTGTGTGCCGCACAGGAACGCTCCCGGCTCACGTACGCCCAGCACCAGGAGGAG
GATGACCTGCTGAACCTGATCGACGCCCCCAGTGTTGTTGCTAAAACTGAGCAAGAGGTT
GACATTATATTGCCCCAGTTCTCCAAGCTGACAGTCACGGACTTCTTCCAGAAGCTGGGC
CCCTTATCTGTGTTTTCGGCTAACAAGCGGTGGACGCCTCCTCGAAGCATCCGCTTCACT
GCAGAAGAAGGGGACTTGGGGTTCACCTTGAGAGGGAACGCCCCCGTTCAGGTTCACTTC
CTGGATCCTTACTGCTCTGCCTCGGTGGCAGGAGCCCGGGAAGGAGATTATATTGTCTCC
ATTCAGCTTGTGGATTGTAAGTGGCTGACGCTGAGTGAGGTTATGAAGCTGCTGAAGAGC
TTTGGCGAGGACGAGATCGAGATGAAAGTCGTGAGCCTCCTGGACTCCACATCATCCATG
CATAATAAGAGTGCCACATACTCCGTGGGAATGCAGAAAACGTACTCCATGATCTGCTTA
GCCATTGATGATGACGACAAAACTGATAAAACCAAGAAAATCTCCAAGAAGCTTTCCTTC
CTGAGTTGGGGCACCAACAAGAACAGACAGAAGTCAGCCAGCACCTTGTGCCTCCCATCG
GTCGGGGCTGCACGGCCTCAGGTCAAGAAGAAGCTGCCCTCCCCTTTCAGCCTTCTCAAC
TCAGACAGTTCTTGGTACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 686 |
| Molecular Weight
| 76992.6 |
| Theoretical pI
| 6.79 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rhophilin-2
MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENL
LKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKET
KDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGF
VESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQA
GLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPGI
RNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFT
AILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHH
EESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEV
DIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHF
LDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDSTSSM
HNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTNKNRQKSASTLCLPS
VGAARPQVKKKLPSPFSLLNSDSSWY
|
| External Links |
|---|
| GenBank ID Protein
| 228008333 |
| UniProtKB/Swiss-Prot ID
| Q8IUC4 |
| UniProtKB/Swiss-Prot Entry Name
| RHPN2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_033103.4 |
| GeneCard ID
| RHPN2 |
| GenAtlas ID
| RHPN2 |
| HGNC ID
| HGNC:19974 |
| References |
|---|
| General References
| Not Available |