| Identification |
|---|
| HMDB Protein ID
| CDBP03374 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein prune homolog |
| Description
| Not Available |
| Synonyms
|
- DRES-17
- DRES17
- Drosophila-related expressed sequence 17
- HTcD37
- hPrune
|
| Gene Name
| PRUNE |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in pyrophosphatase activity |
| Specific Function
| Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
|
| GO Classification
|
| Cellular Component |
| focal adhesion |
| cytoplasm |
| nucleus |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| pyrophosphatase activity |
| manganese ion binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| transition metal ion binding |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| Molecular Function |
| manganese ion binding |
| inorganic diphosphatase activity |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Cell junction
- focal adhesion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q21 |
| SNPs
| PRUNE |
| Gene Sequence
|
>1362 bp
ATGGAGGACTACCTGCAGGGTTGTCGAGCTGCTCTGCAGGAGTCCCGACCTCTACATGTT
GTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTGGCTTTT
TACCTAGCAAAGACAACTGAGGCTGAGGAAGTCTTTGTGCCAGTTTTAAATATAAAACGT
TCTGAACTACCTCTGCGAGGTGACATTGTCTTCTTTCTTCAGAAGGTTCATATTCCAGAG
AGTATCTTGATTTTTCGGGATGAGATTGACCTCCATGCATTATACCAGGCTGGCCAACTC
ACCCTCATCCTTGTCGACCATCATATCTTATCCAAAAGTGACACAGCCCTAGAGGAGGCA
GTAGCAGAGGTGCTAGACCATCGACCCATCGAGCCGAAACACTGCCCTCCCTGCCATGTT
TCAGTTGAGCTGGTGGGGTCCTGTGCTACCCTGGTGACCGAGAGAATCCTGCAGGGGGCA
CCAGAGATCTTGGACAGGCAAACTGCAGCCCTTCTGCATGGAACCATCATCCTGGACTGT
GTCAACATGGACCTTAAAATTGGAAAGGCAACCCCAAAGGACAGCAAATATGTGGAGAAA
CTAGAGGCCCTTTTCCCAGACCTACCCAAGAGAAATGATATATTTGATTCCCTACAAAAG
GTAAAGTTTGATGTATCAGGACTGACCACTGAGCAGATGCTGAGAAAAGACCAGAAGACT
ATCTATAGACAAGGCGTCAAGGTGGCCATTAGTGCAATATATATGGATTTGGAGGCCTTT
CTGCAGAGGTCTAACCTCCTTGCAGATCTCCATGCTTTCTGCCAGGCTCACAGCTATGAT
GTCCTGGTTGCCATGACTATCTTTTTCAACACTCACAATGAGCCAGTGCGGCAGTTGGCT
ATTTTCTGTCCCCATGTGGCACTCCAAACAACGATCTGTGAAGTCCTGGAACGCTCCCAC
TCTCCACCCCTGAAGCTGACCCCTGCCTCAAGTACCCACCCTAACCTCCATGCCTATCTT
CAAGGCAACACCCAGGTCTCTCGAAAGAAACTTCTGCCCCTGCTCCAGGAAGCCCTGTCA
GCATATTTTGACTCCATGAAGATCCCTTCAGGACAGCCTGAGACAGCAGATGTGTCCAGG
GAGCAAGTGGACAAGGAATTGGACAGGGCAAGTAACTCCCTGATTTCTGGACTGAGTCAA
GATGAGGAGGACCCTCCGCTGCCCCCGACGCCCATGAACAGCTTGGTGGATGAGTGCCCT
CTAGATCAGGGGCTGCCTAAACTCTCTGCTGAGGCCGTCTTCGAGAAGTGCAGTCAGATC
TCACTGTCACAGTCTACCACAGCCTCCCTGTCCAAGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 453 |
| Molecular Weight
| 50199.04 |
| Theoretical pI
| 5.502 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein prune homolog
MEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNIKR
SELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKSDTALEEA
VAEVLDHRPIEPKHCPPCHVSVELVGSCATLVTERILQGAPEILDRQTAALLHGTIILDC
VNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQKT
IYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLA
IFCPHVALQTTICEVLERSHSPPLKLTPASSTHPNLHAYLQGNTQVSRKKLLPLLQEALS
AYFDSMKIPSGQPETADVSREQVDKELDRASNSLISGLSQDEEDPPLPPTPMNSLVDECP
LDQGLPKLSAEAVFEKCSQISLSQSTTASLSKK
|
| External Links |
|---|
| GenBank ID Protein
| 4007408 |
| UniProtKB/Swiss-Prot ID
| Q86TP1 |
| UniProtKB/Swiss-Prot Entry Name
| PRUNE_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF051907 |
| GeneCard ID
| PRUNE |
| GenAtlas ID
| PRUNE |
| HGNC ID
| HGNC:13420 |
| References |
|---|
| General References
| Not Available |