Showing Protein Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (CDBP03367)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP03367
Secondary Accession Numbers Not Available
Name Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Description Not Available
Synonyms
  1. NHE3 kinase A regulatory protein E3KARP
  2. NHERF-2
  3. SIP-1
  4. SRY-interacting protein 1
  5. Sodium-hydrogen exchanger regulatory factor 2
  6. Solute carrier family 9 isoform A3 regulatory factor 2
  7. TKA-1
  8. Tyrosine kinase activator protein 1
Gene Name SLC9A3R2
Protein Type Enzyme
Biological Properties
General Function Involved in protein binding
Specific Function Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus
GO Classification
Function
binding
protein binding
Cellular Location
  1. Nucleus
  2. Endomembrane system
  3. Peripheral membrane protein
  4. Apical cell membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16p13.3
SNPs SLC9A3R2
Gene Sequence 
>1014 bp
ATGGCCGCGCCGGAGCCGCTGCGGCCGCGCCTGTGCCGCTTGGTGCGCGGAGAGCAGGGC
TACGGCTTCCACCTGCACGGCGAGAAGGGCCGCCGCGGGCAGTTCATCCGGCGCGTGGAA
CCCGGTTCCCCCGCCGAGGCCGCCGCGCTGCGCGCTGGGGACCGCCTGGTCGAGGTCAAC
GGCGTCAACGTGGAGGGCGAGACGCACCACCAGGTGGTGCAAAGGATCAAGGCTGTGGAG
GGGCAGACTCGGCTGCTGGTGGTGGACCAGGAGACAGATGAGGAGCTCCGCCGGCGGCAG
CTGACCTGTACCGAGGAGATGGCCCAGCGAGGGCTCCCACCCGCCCACGACCCCTGGGAG
CCGAAGCCAGACTGGGCACACACCGGCAGCCACAGCTCCGAAGCTGGCAAGAAGGATGTC
AGTGGGCCCCTGAGGGAGCTGCGCCCTCGGCTCTGCCACCTGCGAAAGGGACCTCAGGGC
TATGGGTTCAACCTGCATAGTGACAAGTCCCGGCCCGGCCAGTACATCCGCTCTGTGGAC
CCGGGCTCACCTGCCGCCCGCTCTGGCCTCCGCGCCCAGGACCGGCTCATTGAGGTGAAC
GGGCAGAATGTGGAGGGACTGCGCCATGCTGAGGTGGTGGCCAGCATCAAGGCACGGGAG
GACGAGGCCCGGCTGCTGGTCGTGGACCCCGAGACAGATGAACACTTCAAGCGGCTTCGG
GTCACACCCACCGAGGAGCACGTGGAAGGTCCTCTGCCGTCACCCGTCACCAATGGAACC
AGCCCTGCCCAGCTCAATGGTGGCTCTGCGTGCTCGTCCCGAAGTGACCTGCCTGGTTCC
GACAAGGACACTGAGGATGGCAGTGCCTGGAAGCAAGATCCCTTCCAGGAGAGCGGCCTC
CACCTGAGCCCCACGGCGGCCGAGGCCAAGGAGAAGGCTCGAGCCATGCGAGTCAACAAG
CGCGCGCCACAGATGGACTGGAACAGGAAGCGTGAAATCTTCAGCAACTTCTGA
Protein Properties
Number of Residues 337
Molecular Weight 37413.5
Theoretical pI 8.06
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Na(+)/H(+) exchange regulatory cofactor NHE-RF2
MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN
GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE
PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD
PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR
VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGL
HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF
GenBank ID Protein 194018553
UniProtKB/Swiss-Prot ID Q15599
UniProtKB/Swiss-Prot Entry Name NHRF2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001130012.1
GeneCard ID SLC9A3R2
GenAtlas ID SLC9A3R2
HGNC ID HGNC:11076
References
General References Not Available