Showing Protein Mas-related G-protein coupled receptor member X2 (CDBP03365)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP03365
Secondary Accession Numbers Not Available
Name Mas-related G-protein coupled receptor member X2
Description Not Available
Synonyms Not Available
Gene Name MRGPRX2
Protein Type Receptor
Biological Properties
General Function Involved in G-protein coupled receptor protein signaling pathway
Specific Function Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin- stimulated cAMP levels, suggesting that this receptor is G(q)- coupled
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Process
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11p15.1
SNPs MRGPRX2
Gene Sequence 
>993 bp
ATGGATCCAACCACCCCGGCCTGGGGAACAGAAAGTACAACAGTGAATGGAAATGACCAA
GCCCTTCTTCTGCTTTGTGGCAAGGAGACCCTGATCCCGGTCTTCCTGATCCTTTTCATT
GCCCTGGTCGGGCTGGTAGGAAACGGGTTTGTGCTCTGGCTCCTGGGCTTCCGCATGCGC
AGGAACGCCTTCTCTGTCTACGTCCTCAGCCTGGCCGGGGCCGACTTCCTCTTCCTCTGC
TTCCAGATTATAAATTGCCTGGTGTACCTCAGTAACTTCTTCTGTTCCATCTCCATCAAT
TTCCCTAGCTTCTTCACCACTGTGATGACCTGTGCCTACCTTGCAGGCCTGAGCATGCTG
AGCACCGTCAGCACCGAGCGCTGCCTGTCCGTCCTGTGGCCCATCTGGTATCGCTGCCGC
CGCCCCAGACACCTGTCAGCGGTCGTGTGTGTCCTGCTCTGGGCCCTGTCCCTACTGCTG
AGCATCTTGGAAGGGAAGTTCTGTGGCTTCTTATTTAGTGATGGTGACTCTGGTTGGTGT
CAGACATTTGATTTCATCACTGCAGCGTGGCTGATTTTTTTATTCATGGTTCTCTGTGGG
TCCAGTCTGGCCCTGCTGGTCAGGATCCTCTGTGGCTCCAGGGGTCTGCCACTGACCAGG
CTGTACCTGACCATCCTGCTCACAGTGCTGGTGTTCCTCCTCTGCGGCCTGCCCTTTGGC
ATTCAGTGGTTCCTAATATTATGGATCTGGAAGGATTCTGATGTCTTATTTTGTCATATT
CATCCAGTTTCAGTTGTCCTGTCATCTCTTAACAGCAGTGCCAACCCCATCATTTACTTC
TTCGTGGGCTCTTTTAGGAAGCAGTGGCGGCTGCAGCAGCCGATCCTCAAGCTGGCTCTC
CAGAGGGCTCTGCAGGACATTGCTGAGGTGGATCACAGTGAAGGATGCTTCCGTCAGGGC
ACCCCGGAGATGTCGAGAAGCAGTCTGGTGTAG
Protein Properties
Number of Residues 330
Molecular Weight 37098.7
Theoretical pI 8.04
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["34-54", "64-84", "97-117", "145-165", "185-205", "229-249", "265-285"]
Protein Sequence 
>Mas-related G-protein coupled receptor member X2
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMR
RNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSML
STVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWC
QTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFG
IQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLAL
QRALQDIAEVDHSEGCFRQGTPEMSRSSLV
GenBank ID Protein 21928888
UniProtKB/Swiss-Prot ID Q96LB1
UniProtKB/Swiss-Prot Entry Name MRGX2_HUMAN
PDB IDs Not Available
GenBank Gene ID AB065811
GeneCard ID MRGPRX2
GenAtlas ID MRGPRX2
HGNC ID HGNC:17983
References
General References Not Available