Showing Protein Mas-related G-protein coupled receptor member D (CDBP03364)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP03364
Secondary Accession Numbers Not Available
Name Mas-related G-protein coupled receptor member D
Description Not Available
Synonyms
  1. Beta-alanine receptor
  2. G-protein coupled receptor TGR7
Gene Name MRGPRD
Protein Type Receptor
Biological Properties
General Function Involved in G-protein coupled receptor protein signaling pathway
Specific Function May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i)
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Process
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11q13.3
SNPs MRGPRD
Gene Sequence 
>966 bp
ATGAACCAGACTTTGAATAGCAGTGGGACCGTGGAGTCAGCCCTAAACTATTCCAGAGGG
AGCACAGTGCACACGGCCTACCTGGTGCTGAGCTCCCTGGCCATGTTCACCTGCCTGTGC
GGGATGGCAGGCAACAGCATGGTGATCTGGCTGCTGGGCTTTCGAATGCACAGGAACCCC
TTCTGCATCTATATCCTCAACCTGGCGGCAGCCGACCTCCTCTTCCTCTTCAGCATGGCT
TCCACGCTCAGCCTGGAAACCCAGCCCCTGGTCAATACCACTGACAAGGTCCACGAGCTG
ATGAAGAGACTGATGTACTTTGCCTACACAGTGGGCCTGAGCCTGCTGACGGCCATCAGC
ACCCAGCGCTGTCTCTCTGTCCTCTTCCCTATCTGGTTCAAGTGTCACCGGCCCAGGCAC
CTGTCAGCCTGGGTGTGTGGCCTGCTGTGGACACTCTGTCTCCTGATGAACGGGTTGACC
TCTTCCTTCTGCAGCAAGTTCTTGAAATTCAATGAAGATCGGTGCTTCAGGGTGGACATG
GTCCAGGCCGCCCTCATCATGGGGGTCTTAACCCCAGTGATGACTCTGTCCAGCCTGACC
CTCTTTGTCTGGGTGCGGAGGAGCTCCCAGCAGTGGCGGCGGCAGCCCACACGGCTGTTC
GTGGTGGTCCTGGCCTCTGTCCTGGTGTTCCTCATCTGTTCCCTGCCTCTGAGCATCTAC
TGGTTTGTGCTCTACTGGTTGAGCCTGCCGCCCGAGATGCAGGTCCTGTGCTTCAGCTTG
TCACGCCTCTCCTCGTCCGTAAGCAGCAGCGCCAACCCCGTCATCTACTTCCTGGTGGGC
AGCCGGAGGAGCCACAGGCTGCCCACCAGGTCCCTGGGGACTGTGCTCCAACAGGCGCTT
CGCGAGGAGCCCGAGCTGGAAGGTGGGGAGACGCCCACCGTGGGCACCAATGAGATGGGG
GCTTGA
Protein Properties
Number of Residues 321
Molecular Weight 36117.2
Theoretical pI 9.04
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["34-54", "60-80", "113-133", "143-163", "185-205", "219-239", "258-280"]
Protein Sequence 
>Mas-related G-protein coupled receptor member D
MNQTLNSSGTVESALNYSRGSTVHTAYLVLSSLAMFTCLCGMAGNSMVIWLLGFRMHRNP
FCIYILNLAAADLLFLFSMASTLSLETQPLVNTTDKVHELMKRLMYFAYTVGLSLLTAIS
TQRCLSVLFPIWFKCHRPRHLSAWVCGLLWTLCLLMNGLTSSFCSKFLKFNEDRCFRVDM
VQAALIMGVLTPVMTLSSLTLFVWVRRSSQQWRRQPTRLFVVVLASVLVFLICSLPLSIY
WFVLYWLSLPPEMQVLCFSLSRLSSSVSSSANPVIYFLVGSRRSHRLPTRSLGTVLQQAL
REEPELEGGETPTVGTNEMGA
GenBank ID Protein 42794265
UniProtKB/Swiss-Prot ID Q8TDS7
UniProtKB/Swiss-Prot Entry Name MRGRD_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_198923.2
GeneCard ID MRGPRD
GenAtlas ID MRGPRD
HGNC ID HGNC:29626
References
General References Not Available