| Identification |
|---|
| HMDB Protein ID
| CDBP03362 |
| Secondary Accession Numbers
| Not Available |
| Name
| Leucine zipper putative tumor suppressor 1 |
| Description
| Not Available |
| Synonyms
|
- F37/esophageal cancer-related gene-coding leucine-zipper motif
- Fez1
|
| Gene Name
| LZTS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor |
| GO Classification
|
| Component |
| membrane |
| cell part |
| intracellular part |
| cytoplasm |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Cell junction
- Cell junction
- synapse
- synapse
- Cell projection
- dendritic spine
- postsynaptic cell membrane
- postsynaptic density
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p22 |
| SNPs
| LZTS1 |
| Gene Sequence
|
>1791 bp
ATGGGCAGCGTCAGTAGCCTCATCTCCGGCCACAGCTTCCACAGCAAGCACTGCCGGGCT
TCGCAGTACAAGCTGCGCAAGTCCTCCCACCTCAAGAAGCTCAACCGGTATTCCGACGGG
CTGCTGAGGTTTGGCTTCTCCCAGGACTCCGGTCACGGCAAGTCCAGCTCCAAAATGGGC
AAGAGCGAAGACTTCTTCTACATCAAGGTCAGCCAGAAAGCCCGGGGCTCCCATCACCCA
GATTACACGGCACTGTCCAGCGGGGATTTAGGGGGCCAGGCTGGGGTGGACTTTGACCCG
TCCACACCCCCCAAGCTCATGCCCTTCTCCAATCAGCTAGAAATGGGCTCCGAGAAGGGT
GCAGTGAGGCCCACAGCCTTCAAGCCTGTGCTGCCACGGTCAGGAGCCATCCTGCACTCC
TCCCCGGAGAGTGCCAGCCACCAGCTGCACCCCGCCCCTCCAGACAAGCCCAAGGAGCAG
GAGCTGAAGCCTGGCCTGTGCTCTGGGGCGCTGTCAGACTCCGGCCGGAACTCCATGTCC
AGCCTGCCCACACACAGCACCAGCAGCAGCTACCAGCTGGACCCGCTGGTCACACCCGTG
GGACCCACAAGCCGTTTTGGGGGCTCCGCCCACAACATCACCCAGGGCATCGTCCTCCAG
GACAGCAACATGATGAGCCTGAAGGCTCTGTCCTTCTCCGACGGAGGTAGCAAGCTGGGC
CACTCGAACAAGGCAGACAAGGGCCCCTCGTGTGTCCGCTCCCCCATCTCCACGGACGAG
TGCAGCATCCAGGAGCTGGAGCAGAAGCTGTTGGAGAGGGAGGGCGCCCTCCAGAAGCTG
CAGCGCAGCTTTGAGGAGAAGGAGCTTGCCTCCAGCCTGGCCTACGAGGAGCGGCCGCGG
CGCTGCAGGGACGAGCTGGAGGGCCCGGAGCCCAAAGGCGGCAACAAGCTCAAGCAGGCC
TCGCAGAAGAGCCAGCGCGCGCAGCAGGTCCTGCACCTGCAGGTACTGCAGCTTCAGCAG
GAGAAGCGGCAGCTCCGGCAGGAGCTCGAGAGCCTCATGAAGGAGCAGGACCTGCTGGAG
ACCAAGCTCAGGTCCTACGAGAGGGAGAAGACCAGCTTCGGCCCCGCGCTGGAGGAGACC
CAGTGGGAGGTGTGCCAGAAGTCAGGCGAGATCTCCCTCCTGAAGCAGCAGCTGAAGGAG
TCCCAGACGGAGGTGAACGCCAAGGCTAGCGAGATCCTGGGTCTCAAGGCACAGCTGAAG
GACACGCGGGGCAAGCTGGAGGGCCTGGAGCTGAGGACCCAGGACCTGGAGGGCGCCCTG
CGCACCAAGGGCCTGGAGCTGGAGGTCTGTGAGAATGAGCTGCAGCGCAAGAAGAACGAG
GCGGAGCTGCTGCGGGAGAAGGTGAACCTGCTGGAGCAGGAGCTGCAGGAGCTGCGGGCC
CAGGCCGCCCTGGCCCGCGACATGGGGCCGCCCACCTTCCCCGAGGACGTCCCTGCCCTG
CAGCGGGAGCTGGAGCGGCTGCGGGCCGAGCTGCGGGAGGAGCGGCAAGGCCATGACCAG
ATGTCCTCGGGCTTCCAGCATGAGCGGCTCGTGTGGAAGGAGGAGAAGGAGAAGGTGATT
CAGTACCAGAAACAGCTGCAGCAGAGCTACGTGGCCATGTACCAGCGGAACCAGCGCCTG
GAGAAGGCCCTGCAGCAGCTGGCACGTGGGGACAGCGCCGGGGAGCCCTTGGAGGTTGAC
CTGGAAGGGGCTGACATCCCCTACGAGGACATCATAGCCACTGAGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 596 |
| Molecular Weight
| 66612.4 |
| Theoretical pI
| 7.1 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Leucine zipper putative tumor suppressor 1
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMG
KSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKG
AVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMS
SLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLG
HSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPR
RCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLE
TKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK
DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRA
QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVI
QYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI
|
| External Links |
|---|
| GenBank ID Protein
| 10440566 |
| UniProtKB/Swiss-Prot ID
| Q9Y250 |
| UniProtKB/Swiss-Prot Entry Name
| LZTS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_021020.2 |
| GeneCard ID
| LZTS1 |
| GenAtlas ID
| LZTS1 |
| HGNC ID
| HGNC:13861 |
| References |
|---|
| General References
| Not Available |