| Identification |
|---|
| HMDB Protein ID
| CDBP03359 |
| Secondary Accession Numbers
| Not Available |
| Name
| Potassium voltage-gated channel subfamily H member 5 |
| Description
| Not Available |
| Synonyms
|
- Ether-a-go-go potassium channel 2
- Voltage-gated potassium channel subunit Kv10.2
- hEAG2
|
| Gene Name
| KCNH5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| protein kinase activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| potassium channel activity |
| voltage-gated potassium channel activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| protein histidine kinase activity |
| two-component sensor activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| molecular transducer activity |
| signal transducer activity |
| Process |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| regulation of cellular process |
| signal transduction |
| transmembrane transport |
| monovalent inorganic cation transport |
| signaling process |
| potassium ion transport |
| signal transmission |
| ion transport |
| two-component signal transduction system (phosphorelay) |
| cation transport |
| establishment of localization |
| transport |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q23.1 |
| SNPs
| KCNH5 |
| Gene Sequence
|
>2967 bp
ATGCCGGGGGGCAAGAGAGGGCTGGTGGCACCGCAGAACACATTTTTGGAGAACATCGTC
AGGCGCTCCAGTGAATCAAGTTTCTTACTGGGAAATGCCCAGATTGTGGATTGGCCTGTA
GTTTATAGTAATGACGGTTTTTGTAAACTCTCTGGATATCATCGAGCTGACGTCATGCAG
AAAAGCAGCACTTGCAGTTTTATGTATGGGGAATTGACTGACAAGAAGACCATTGAGAAA
GTCAGGCAAACTTTTGACAACTACGAATCAAACTGCTTTGAAGTTCTTCTGTACAAGAAA
AACAGAACCCCTGTTTGGTTTTATATGCAAATTGCACCAATAAGAAATGAACATGAAAAG
GTGGTCTTGTTCCTGTGTACTTTCAAGGATATTACGTTGTTCAAACAGCCAATAGAGGAT
GATTCAACAAAAGGTTGGACGAAATTTGCCCGATTGACACGGGCTTTGACAAATAGCCGA
AGTGTTTTGCAGCAGCTCACGCCAATGAATAAAACAGAGGTGGTCCATAAACATTCAAGA
CTAGCTGAAGTTCTTCAGCTGGGATCAGATATCCTTCCTCAGTATAAACAAGAAGCGCCA
AAGACGCCACCACACATTATTTTACATTATTGTGCTTTTAAAACTACTTGGGATTGGGTG
ATTTTAATTCTTACCTTCTACACCGCCATTATGGTTCCTTATAATGTTTCCTTCAAAACA
AAGCAGAACAACATAGCCTGGCTGGTACTGGATAGTGTGGTGGACGTTATTTTTCTGGTT
GACATCGTTTTAAATTTTCACACGACTTTCGTGGGGCCCGGTGGAGAGGTCATTTCTGAC
CCTAAGCTCATAAGGATGAACTATCTGAAAACTTGGTTTGTGATCGATCTGCTGTCTTGT
TTACCTTATGACATCATCAATGCCTTTGAAAATGTGGATGAGGGAATCAGCAGTCTCTTC
AGTTCTTTAAAAGTGGTGCGTCTCTTACGACTGGGCCGTGTGGCTAGGAAACTGGACCAT
TACCTAGAATATGGAGCAGCAGTCCTCGTGCTCCTGGTGTGTGTGTTTGGACTGGTGGCC
CACTGGCTGGCCTGCATATGGTATAGCATCGGAGACTACGAGGTCATTGATGAAGTCACT
AACACCATCCAAATAGACAGTTGGCTCTACCAGCTGGCTTTGAGCATTGGGACTCCATAT
CGCTACAATACCAGTGCTGGGATATGGGAAGGAGGACCCAGCAAGGATTCATTGTACGTG
TCCTCTCTCTACTTTACCATGACAAGCCTTACAACCATAGGATTTGGAAACATAGCTCCT
ACCACAGATGTGGAGAAGATGTTTTCGGTGGCTATGATGATGGTTGGCTCTCTTCTTTAT
GCAACTATTTTTGGAAATGTTACAACAATTTTCCAGCAAATGTATGCCAACACCAACCGA
TACCATGAGATGCTGAATAATGTACGGGACTTCCTAAAACTCTATCAGGTCCCAAAAGGC
CTTAGTGAGCGAGTCATGGATTATATTGTCTCAACATGGTCCATGTCAAAAGGCATTGAT
ACAGAAAAGGTCCTCTCCATCTGTCCCAAGGACATGAGAGCTGATATCTGTGTTCATCTA
AACCGGAAGGTTTTTAATGAACATCCTGCTTTTCGATTGGCCAGCGATGGGTGTCTGCGC
GCCTTGGCGGTAGAGTTCCAAACCATTCACTGTGCTCCCGGGGACCTCATTTACCATGCT
GGAGAAAGTGTGGATGCCCTCTGCTTTGTGGTGTCAGGATCCTTGGAAGTCATCCAGGAT
GATGAGGTGGTGGCTATTTTAGGGAAGGGTGATGTATTTGGAGACATCTTCTGGAAGGAA
ACCACCCTTGCCCATGCATGTGCGAACGTCCGGGCACTGACGTACTGTGACCTACACATC
ATCAAGCGGGAAGCCTTGCTCAAAGTCCTGGACTTTTATACAGCTTTTGCAAACTCCTTC
TCAAGGAATCTCACTCTTACTTGCAATCTGAGGAAACGGATCATCTTTCGTAAGATCAGT
GATGTGAAGAAAGAGGAGGAGGAGCGCCTCCGGCAGAAGAATGAGGTGACCCTCAGCATT
CCCGTGGACCACCCAGTCAGAAAGCTCTTCCAGAAGTTCAAGCAGCAGAAGGAGCTGCGG
AATCAGGGCTCAACACAGGGTGACCCTGAGAGGAACCAACTCCAGGTAGAGAGCCGCTCC
TTACAGAATGGAACCTCCATCACCGGAACCAGCGTGGTGACTGTGTCACAGATTACTCCC
ATTCAGACGTCTCTGGCCTATGTGAAAACCAGTGAATCCCTTAAGCAGAACAACCGTGAT
GCCATGGAACTCAAGCCCAACGGCGGTGCTGACCAAAAATGTCTCAAAGTCAACAGCCCA
ATAAGAATGAAGAATGGAAATGGAAAAGGGTGGCTGCGACTCAAGAATAATATGGGAGCC
CATGAGGAGAAAAAGGAAGACTGGAATAATGTCACTAAAGCTGAGTCAATGGGGCTATTG
TCTGAGGACCCCAAGAGCAGTGATTCAGAGAACAGTGTGACCAAAAACCCACTAAGGAAA
ACAGATTCTTGTGACAGTGGAATTACAAAAAGTGACCTTCGTTTGGATAAGGCTGGGGAG
GCCCGAAGTCCGCTAGAGCACAGTCCCATCCAGGCTGATGCCAAGCACCCCTTTTATCCC
ATCCCCGAGCAGGCCTTACAGACCACACTGCAGGAAGTCAAACACGAACTCAAAGAGGAC
ATCCAGCTGCTCAGCTGCAGAATGACTGCCCTAGAAAAGCAGGTGGCAGAAATTTTAAAA
ATACTGTCGGAAAAAAGCGTACCCCAGGCCTCATCTCCCAAATCCCAAATGCCACTCCAA
GTACCCCCCCAGATACCATGTCAGGATATTTTTAGTGTCTCAAGGCCTGAATCACCTGAA
TCTGACAAAGATGAAATCCACTTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 988 |
| Molecular Weight
| 111905.7 |
| Theoretical pI
| 7.62 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["218-238", "244-264", "292-312", "320-340", "347-367", "447-467"]
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily H member 5
MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ
KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK
VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSR
LAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKT
KQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSC
LPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVA
HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYV
SSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNR
YHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHL
NRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQD
DEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSF
SRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELR
NQGSTQGDPERNQLQVESRSLQNGTSITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRD
AMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLL
SEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYP
IPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQ
VPPQIPCQDIFSVSRPESPESDKDEIHF
|
| External Links |
|---|
| GenBank ID Protein
| 20799308 |
| UniProtKB/Swiss-Prot ID
| Q8NCM2 |
| UniProtKB/Swiss-Prot Entry Name
| KCNH5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF418206 |
| GeneCard ID
| KCNH5 |
| GenAtlas ID
| KCNH5 |
| HGNC ID
| HGNC:6254 |
| References |
|---|
| General References
| Not Available |