Showing Protein Potassium voltage-gated channel subfamily E member 3 (CDBP03355)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03355
Secondary Accession Numbers Not Available
Name Potassium voltage-gated channel subfamily E member 3
Description Not Available
Synonyms
  1. MinK-related peptide 2
  2. Minimum potassium ion channel-related peptide 2
  3. Potassium channel subunit beta MiRP2
Gene Name KCNE3
Protein Type Transporter
Biological Properties
General Function Involved in voltage-gated potassium channel activity
Specific Function Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion
GO Classification
Component
membrane
cell part
Function
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport
Cellular Location
  1. Membrane
  2. Single-pass type I membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11q13.4
SNPs KCNE3
Gene Sequence 
>312 bp
ATGGAGACTACCAATGGAACGGAGACCTGGTATGAGAGCCTGCATGCCGTGCTGAAGGCT
CTAAATGCCACTCTTCACAGCAATTTGCTCTGCCGGCCAGGGCCAGGGCTGGGGCCAGAC
AACCAGACTGAAGAGAGGCGGGCCAGCCTACCTGGCCGTGATGACAACTCCTACATGTAC
ATTCTCTTTGTCATGTTTCTATTTGCTGTAACTGTGGGCAGCCTCATCCTGGGATACACC
CGCTCCCGCAAAGTGGACAAGCGTAGTGACCCCTATCATGTGTATATCAAGAACCGTGTG
TCTATGATCTAA
Protein Properties
Number of Residues 103
Molecular Weight 11710.3
Theoretical pI 9.01
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["58-78"]
Protein Sequence 
>Potassium voltage-gated channel subfamily E member 3
METTNGTETWYESLHAVLKALNATLHSNLLCRPGPGLGPDNQTEERRASLPGRDDNSYMY
ILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMI
GenBank ID Protein 4704429
UniProtKB/Swiss-Prot ID Q9Y6H6
UniProtKB/Swiss-Prot Entry Name KCNE3_HUMAN
PDB IDs Not Available
GenBank Gene ID AF076531
GeneCard ID KCNE3
GenAtlas ID KCNE3
HGNC ID HGNC:6243
References
General References Not Available