| Identification |
|---|
| HMDB Protein ID
| CDBP03354 |
| Secondary Accession Numbers
| Not Available |
| Name
| Potassium voltage-gated channel subfamily A member 10 |
| Description
| Not Available |
| Synonyms
|
- Voltage-gated potassium channel subunit Kv1.8
|
| Gene Name
| KCNA10 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP |
| GO Classification
|
| Component |
| ion channel complex |
| cation channel complex |
| potassium channel complex |
| voltage-gated potassium channel complex |
| macromolecular complex |
| protein complex |
| membrane |
| cell part |
| Function |
| binding |
| protein binding |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| potassium channel activity |
| voltage-gated potassium channel activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p13.1 |
| SNPs
| KCNA10 |
| Gene Sequence
|
>1536 bp
ATGGATGTGTGTGGCTGGAAAGAAATGGAGGTTGCGCTGGTCAATTTTGATAATTCAGAT
GAAATCCAAGAAGAGCCAGGCTATGCCACAGACTTCGACTCAACCAGCCCAAAAGGCCGG
CCTGGGGGCAGCTCCTTCTCCAACGGGAAGATCCTCATCAGCGAAAGCACCAACCATGAG
ACGGCCTTCTCCAAGCTTCCGGGAGACTATGCTGACCCCCCAGGGCCTGAGCCAGTGGTC
CTAAATGAAGGAAACCAGCGGGTGATCATCAACATTGCTGGGCTGAGATTTGAGACCCAG
CTCAGAACCCTTAGTCAGTTCCCAGAGACTCTCCTGGGAGACCGGGAGAAAAGGATGCAG
TTCTTTGACTCCATGAGAAATGAGTATTTCTTTGATCGTAACCGGCCCAGTTTTGATGGA
ATCCTATATTATTACCAATCTGGTGGGAAAATTCGGCGCCCAGCCAATGTTCCCATTGAT
ATCTTTGCTGATGAAATCTCCTTCTATGAGCTGGGTAGTGAGGCCATGGACCAGTTCCGG
GAGGATGAAGGCTTCATCAAAGACCCTGAAACACTGCTACCCACCAATGACATCCACCGT
CAGTTCTGGCTCCTCTTTGAGTACCCTGAAAGTTCCAGCGCTGCCCGTGCTGTGGCCGTG
GTCTCGGTGTTGGTTGTGGTCATCTCCATCACCATCTTCTGCCTGGAGACACTGCCAGAG
TTCCGGGAGGATAGGGAGCTGAAGGTGGTCAGAGACCCCAATCTCAACATGAGCAAGACA
GTCCTCTCCCAGACCATGTTCACCGACCCTTTCTTCATGGTGGAGTCTACCTGCATCGTG
TGGTTCACCTTCGAGCTGGTGCTCCGGTTCGTGGTCTGCCCCAGCAAGACTGACTTCTTC
AGGAACATCATGAACATCATTGACATCATCTCCATTATCCCCTACTTTGCAACTCTCATC
ACAGAGCTAGTCCAGGAGACAGAGCCGAGTGCCCAACAGAACATGTCCCTGGCCATCCTG
AGGATCATCCGCCTGGTGAGGGTCTTCCGCATCTTCAAGCTCTCGCGCCACTCCAAGGGG
CTGCAGATCCTCGGGCAAACACTGAAGGCGTCCATGCGGGAGTTGGGGTTGCTCATCTTC
TTTCTCTTCATTGGAGTCATCCTCTTCTCCAGTGCAGTCTACTTTGCTGAGGTGGATGAG
CCAGAGTCCCATTTCTCTAGCATTCCTGATGGCTTCTGGTGGGCAGTGGTCACCATGACA
ACTGTAGGCTATGGGGACATGTGCCCGACCACCCCAGGGGGGAAGATTGTGGGCACTCTG
TGTGCCATTGCAGGGGTCCTCACCATTGCCCTCCCTGTGCCTGTCATTGTCTCCAACTTC
AATTACTTCTACCACCGGGAGACTGAGAATGAAGAAAAGCAGAACATCCCGGGAGAAATT
GAAAGAATCCTCAACAGTGTAGGCTCAAGAATGGGCAGCACAGACTCTCTTAATAAGACC
AATGGTGGCTGTTCCACAGAGAAGTCTAGGAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 511 |
| Molecular Weight
| 57784.5 |
| Theoretical pI
| 4.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["218-238", "271-292", "303-323", "339-358", "375-395", "436-456"]
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily A member 10
MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHE
TAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQ
FFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFR
EDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPE
FREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFF
RNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKG
LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMT
TVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEI
ERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
|
| External Links |
|---|
| GenBank ID Protein
| 50959682 |
| UniProtKB/Swiss-Prot ID
| Q16322 |
| UniProtKB/Swiss-Prot Entry Name
| KCA10_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC074990 |
| GeneCard ID
| KCNA10 |
| GenAtlas ID
| KCNA10 |
| HGNC ID
| HGNC:6219 |
| References |
|---|
| General References
| Not Available |