| Identification |
|---|
| HMDB Protein ID
| CDBP03341 |
| Secondary Accession Numbers
| Not Available |
| Name
| FERM, RhoGEF and pleckstrin domain-containing protein 1 |
| Description
| Not Available |
| Synonyms
|
- Chondrocyte-derived ezrin-like protein
- PH domain-containing family C member 2
- Pleckstrin homology domain-containing family C member 2
|
| Gene Name
| FARP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| May function as Rho-guanine nucleotide exchange factor |
| GO Classification
|
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| cytoskeleton |
| membrane part |
| organelle |
| extrinsic to membrane |
| intracellular |
| non-membrane-bounded organelle |
| intracellular non-membrane-bounded organelle |
| Function |
| cytoskeletal protein binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| small gtpase regulator activity |
| binding |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| protein binding |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q32.2 |
| SNPs
| FARP1 |
| Gene Sequence
|
>3138 bp
ATGGGAGAAATAGAGCAGAGGCCGACCCCAGGATCACGACTGGGGGCCCCGGAAAATTCG
GGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAACTCGTG
TCCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCACAAAGAGCT
CCTGGGAAGGTGCTGCTGGATGCAGTTTGCAACCACCTCAACCTCGTGGAAGGTGACTAT
TTTGGCCTCGAGTTTCCTGATCACAAAAAGATCACGGTGTGGCTGGATCTCCTAAAACCC
ATTGTGAAACAGATTAGAAGGCCAAAGCACGTTGTTGTTAAGTTTGTGGTGAAATTCTTT
CCGCCTGACCACACACAACTCCAAGAAGAACTCACAAGGTACCTGTTCGCGCTGCAGGTG
AAGCAGGACTTGGCTCAAGGCAGGTTGACGTGTAATGACACCAGCGCAGCTCTCTTGATT
TCACACATTGTGCAATCTGAGATTGGGGATTTTGATGAAGCCTTGGACAGAGAGCACTTA
GCAAAAAATAAATACATACCTCAGCAAGACGCACTAGAGGACAAAATCGTGGAATTTCAC
CATAACCACATTGGACAAACACCAGCAGAATCAGATTTCCAGCTCCTAGAGATTGCCCGT
CGGCTAGAGATGTATGGAATCCGGTTGCACCCGGCCAAGGACAGGGAAGGCACGAAGATC
AATCTGGCCGTTGCCAACACGGGAATTCTAGTGTTTCAGGGTTTCACTAAGATCAATGCC
TTCAACTGGGCCAAGGTGCGGAAGCTGAGCTTCAAGAGGAAGCGCTTTCTCATCAAGCTC
CGGCCAGATGCCAATAGTGCGTACCAGGATACCTTGGAATTCCTGATGGCCAGTCGGGAT
TTCTGCAAGTCCTTCTGGAAAATCTGTGTTGAACATCATGCCTTCTTTAGACTTTTTGAA
GAGCCCAAACCAAAGCCCAAGCCCGTCCTCTTTAGCCGGGGGTCATCATTTCGGTTCAGT
GGTCGGACTCAGAAGCAGGTTCTCGACTATGTTAAAGAAGGAGGACATAAGAAGGTGCAG
TTTGAAAGGAAGCACAGCAAGATTCATTCTATCCGGAGCCTTGCTTCACAGCCTACAGAA
CTGAATTCGGAAGTGCTGGAGCAGTCTCAGCAGAGCACCAGCCTTACATTTGGAGAAGGT
GCCGAATCTCCAGGGGGCCAGAGCTGCCGGCGAGGAAAGGAACCGAAGGTTTCCGCCGGG
GAGCCGGGGTCGCACCCGAGCCCTGCGCCGAGGAGAAGCCCCGCGGGTAACAAGCAGGCG
GACGGAGCCGCCTCGGCGCCCACGGAGGAAGAGGAGGAGGTCGTTAAGGATAGGACCCAG
CAGAGTAAACCTCAGCCCCCGCAGCCAAGCACAGGCTCCCTGACTGGCAGTCCTCACCTT
TCCGAGCTGTCTGTGAACTCGCAGGGGGGAGTGGCCCCTGCCAACGTGACCTTGTCTCCC
AACCTGAGCCCCGACACCAAGCAGGCCTCTCCCTTGATCAGCCCGCTGCTGAATGACCAG
GCCTGCCCCCGGACGGACGATGAGGATGAGGGCCGGAGGAAGAGATTCCCAACTGATAAA
GCGTACTTCATAGCTAAGGAAGTGTCTACCACCGAGCGAACATATCTGAAGGATCTCGAA
GTTATCACTTCGTGGTTTCAGAGCACAGTGAGCAAAGAGGACGCCATGCCGGAAGCACTG
AAAAGTCTCATATTCCCGAATTTTGAACCTTTGCACAAATTTCATACTAATTTTCTCAAG
GAAATTGAGCAACGACTTGCCCTGTGGGAAGGCCGCTCAAATGCCCAAATCAGAGATTAC
CAAAGAATCGGCGATGTCATGCTGAAGAACATTCAGGGCATGAAGCACCTGGCGGCTCAC
CTGTGGAAGCACAGCGAGGCCTTGGAGGCCCTGGAGAATGGAATCAAGAGCTCCCGGCGG
CTGGAGAACTTCTGCAGAGACTTTGAGCTGCAGAAGGTGTGTTACCTACCGCTCAACACC
TTCCTCCTGCGGCCACTGCACCGGCTCATGCACTACAAGCAGGTCCTGGAGCGGCTGTGC
AAACACCACCCGCCGAGCCACGCCGACTTCAGGGACTGCCGAGCCGCTTTGGCAGAGATC
ACGGAGATGGTGGCACAGCTCCACGGTACGATGATCAAGATGGAGAATTTCCAGAAGCTG
CACGAACTCAAGAAAGATTTGATTGGCATTGACAATCTTGTGGTTCCGGGAAGGGAGTTC
ATCCGTCTGGGCAGCCTCAGCAAGCTCTCGGGGAAGGGGCTCCAGCAGCGCATGTTCTTC
CTGTTCAACGACGTCCTGCTATACACGAGCCGGGGGCTGACGGCCTCCAATCAGTTTAAA
GTCCACGGGCAGCTCCCGCTCTATGGCATGACGATTGAGGAGAGCGAAGACGAGTGGGGG
GTGCCCCACTGCCTGACCCTCCGGGGCCAGCGGCAGTCCATCATCGTGGCCGCCAGTTCT
CGGTCCGAGATGGAGAAGTGGGTTGAGGACATCCAGATGGCCATTGACCTGGCGGAGAAG
AGCAGCAGCCCCGCCCCTGAGTTCCTGGCCAGCAGCCCCCCTGACAACAAGTCCCCTGAT
GAAGCCACCGCGGCTGACCAGGAGTCAGAGGATGACCTGAGCGCCTCGCGCACATCGCTG
GAGCGCCAGGCCCCGCACCGCGGCAACACAATGGTGCACGTGTGCTGGCACCGCAACACC
AGCGTCTCCATGGTGGACTTCAGCATCGCAGTGGAGAATCAGTTGTCTGGAAACCTGCTG
AGGAAATTCAAAAACAGCAACGGGTGGCAGAAGCTGTGGGTGGTGTTCACAAACTTCTGC
CTGTTCTTCTACAAATCACACCAGGACAATCATCCCCTTGCCAGCCTGCCTCTGCTCGGC
TACTCGCTCACCATCCCCTCTGAGTCCGAGAACATCCAGAAAGACTACGTGTTCAAGCTG
CACTTCAAGTCCCACGTCTACTACTTCAGGGCGGAAAGCGAGTACACGTTCGAAAGGTGG
ATGGAAGTGATCCGCAGTGCCACCAGCTCTGCCTCGCGACCCCACGTGTTGAGCCACAAA
GAGTCTCTTGTGTATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1045 |
| Molecular Weight
| 118631.9 |
| Theoretical pI
| 8.27 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>FERM, RhoGEF and pleckstrin domain-containing protein 1
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRA
PGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFF
PPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHL
AKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKI
NLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRD
FCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQ
FERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAG
EPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHL
SELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDK
AYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLK
EIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRR
LENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEI
TEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFF
LFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASS
RSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSL
ERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFC
LFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERW
MEVIRSATSSASRPHVLSHKESLVY
|
| External Links |
|---|
| GenBank ID Protein
| 2766165 |
| UniProtKB/Swiss-Prot ID
| Q9Y4F1 |
| UniProtKB/Swiss-Prot Entry Name
| FARP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB008430 |
| GeneCard ID
| FARP1 |
| GenAtlas ID
| FARP1 |
| HGNC ID
| HGNC:3591 |
| References |
|---|
| General References
| Not Available |