| Identification |
|---|
| HMDB Protein ID
| CDBP03340 |
| Secondary Accession Numbers
| Not Available |
| Name
| Erythrocyte membrane protein band 4.2 |
| Description
| Not Available |
| Synonyms
|
- Erythrocyte protein 4.2
- P4.2
|
| Gene Name
| EPB42 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein-glutamine gamma-glutamyltransferase activity |
| Specific Function
| Probably plays an important role in the regulation of erythrocyte shape and mechanical properties |
| GO Classification
|
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring amino-acyl groups |
| protein-glutamine gamma-glutamyltransferase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| post-translational protein modification |
| peptide cross-linking |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- Cytoplasm
- Cytoplasmic side
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q15-q21 |
| SNPs
| EPB42 |
| Gene Sequence
|
>2076 bp
ATGGGACAGGCCCTGGGTATCAAGAGCTGTGACTTTCAGGCAGCAAGAAACAATGAGGAG
CACCACACCAAGGCCCTCAGCTCCCGGCGCCTCTTTGTGAGGAGGGGGCAGCCCTTCACC
ATCATCCTGTACTTCCGCGCTCCAGTCCGTGCATTTCTGCCTGCCCTGAAGAAGGTGGCC
CTCACTGCACAAACTGGAGAGCAGCCTTCCAAGATCAACAGGACCCAAGCCACATTCCCA
ATTTCCAGTCTGGGGGACCGAAAGTGGTGGAGTGCAGTGGTGGAGGAGAGAGATGCCCAG
TCCTGGACCATCTCTGTGACCACACCTGCGGACGCTGTCATTGGCCACTACTCGCTTCTG
CTGCAGGTCTCAGGCAGGAAGCAACTCCTCTTGGGTCAGTTCACACTGCTTTTTAACCCC
TGGAATAGAGAGGATGCTGTGTTCCTGAAGAATGAGGCTCAGCGCATGGAGTACTTGTTG
AACCAGAATGGTCTCATCTACCTGGGTACAGCTGACTGCATCCAGGCAGAGTCCTGGGAC
TTTGGCCAGTTCGAGGGGGATGTCATTGACCTCAGCCTGCGCTTGCTGAGCAAGGACAAG
CAGGTAGAGAAGTGGAGCCAGCCGGTGCACGTGGCCCGTGTGTTGGGTGCCTTGCTGCAT
TTTCTCAAGGAGCAGAGGGTCCTGCCCACCCCGCAGACCCAGGCCACCCAGGAAGGGGCC
TTGCTGAACAAGCGCCGGGGCAGCGTGCCCATCCTGCGGCAGTGGCTCACCGGCCGAGGC
CGACCTGTGTATGATGGCCAGGCCTGGGTGTTGGCTGCTGTTGCTTGCACAGTGCTGCGA
TGCCTGGGAATCCCTGCCCGCGTGGTGACCACGTTTGCCTCAGCACAGGGCACCGGTGGG
CGTCTTCTCATAGATGAATACTATAATGAGGAGGGACTTCAGAACGGAGAAGGCCAGAGA
GGCAGAATCTGGATCTTCCAGACTTCCACAGAGTGCTGGATGACGCGGCCTGCCTTGCCC
CAGGGTTATGATGGATGGCAGATTCTGCACCCAAGTGCTCCTAATGGAGGTGGAGTCCTG
GGGTCCTGTGATCTGGTGCCGGTCAGAGCAGTCAAGGAGGGGACGCTGGGGCTGACCCCA
GCAGTGTCAGACCTTTTTGCTGCCATAAATGCCTCATGTGTGGTCTGGAAGTGCTGTGAG
GATGGGACACTGGAGTTGACTGACTCCAACACAAAGTATGTTGGCAACAACATCAGCACC
AAGGGTGTGGGCAGTGACCGCTGCGAGGACATCACTCAGAACTACAAGTATCCTGAAGGG
TCTCTTCAGGAAAAAGAGGTGCTGGAGAGAGTCGAGAAAGAGAAAATGGAACGTGAGAAA
GACAACGGCATCCGTCCTCCCAGTCTCGAGACTGCCAGTCCTCTGTACCTGCTCTTGAAA
GCACCCAGCTCCCTACCCCTGAGAGGGGATGCCCAGATCTCAGTGACGCTGGTTAATCAC
AGTGAGCAGGAGAAGGCAGTGCAGCTGGCAATTGGGGTCCAGGCTGTACACTACAACGGT
GTCCTTGCTGCCAAGCTCTGGAGGAAGAAGCTGCACCTCACGCTCAGTGCCAACCTGGAA
AAGATAATAACCATCGGCCTGTTCTTCTCCAATTTTGAGCGAAACCCACCCGAGAACACC
TTCCTTAGACTCACCGCCATGGCAACACACTCTGAATCCAACCTTAGCTGCTTTGCTCAG
GAAGACATTGCCATTTGTAGACCACACCTTGCCATCAAGATGCCAGAGAAAGCAGAGCAG
TATCAACCCCTCACAGCCTCAGTCAGCCTCCAGAACTCCCTAGATGCCCCCATGGAGGAC
TGTGTGATCTCCATCCTGGGAAGGGGGCTCATTCACAGAGAGAGGAGCTACAGATTCCGT
TCAGTGTGGCCTGAAAACACCATGTGTGCCAAGTTCCAGTTCACGCCAACACATGTGGGG
CTCCAGAGACTCACTGTGGAAGTGGACTGCAACATGTTCCAGAACCTAACCAACTATAAA
AGCGTCACCGTGGTAGCCCCTGAACTATCAGCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 691 |
| Molecular Weight
| 77008.5 |
| Theoretical pI
| 8.17 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Erythrocyte membrane protein band 4.2
MGQALGIKSCDFQAARNNEEHHTKALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKVA
LTAQTGEQPSKINRTQATFPISSLGDRKWWSAVVEERDAQSWTISVTTPADAVIGHYSLL
LQVSGRKQLLLGQFTLLFNPWNREDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQAESWD
FGQFEGDVIDLSLRLLSKDKQVEKWSQPVHVARVLGALLHFLKEQRVLPTPQTQATQEGA
LLNKRRGSVPILRQWLTGRGRPVYDGQAWVLAAVACTVLRCLGIPARVVTTFASAQGTGG
RLLIDEYYNEEGLQNGEGQRGRIWIFQTSTECWMTRPALPQGYDGWQILHPSAPNGGGVL
GSCDLVPVRAVKEGTLGLTPAVSDLFAAINASCVVWKCCEDGTLELTDSNTKYVGNNIST
KGVGSDRCEDITQNYKYPEGSLQEKEVLERVEKEKMEREKDNGIRPPSLETASPLYLLLK
APSSLPLRGDAQISVTLVNHSEQEKAVQLAIGVQAVHYNGVLAAKLWRKKLHLTLSANLE
KIITIGLFFSNFERNPPENTFLRLTAMATHSESNLSCFAQEDIAICRPHLAIKMPEKAEQ
YQPLTASVSLQNSLDAPMEDCVISILGRGLIHRERSYRFRSVWPENTMCAKFQFTPTHVG
LQRLTVEVDCNMFQNLTNYKSVTVVAPELSA
|
| External Links |
|---|
| GenBank ID Protein
| 166362737 |
| UniProtKB/Swiss-Prot ID
| P16452 |
| UniProtKB/Swiss-Prot Entry Name
| EPB42_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001114134.1 |
| GeneCard ID
| EPB42 |
| GenAtlas ID
| EPB42 |
| HGNC ID
| HGNC:3381 |
| References |
|---|
| General References
| Not Available |