| Identification |
|---|
| HMDB Protein ID
| CDBP03338 |
| Secondary Accession Numbers
| Not Available |
| Name
| CREB-regulated transcription coactivator 3 |
| Description
| Not Available |
| Synonyms
|
- TORC-3
- Transducer of CREB protein 3
- Transducer of regulated cAMP response element-binding protein 3
|
| Gene Name
| CRTC3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in interspecies interaction between organisms |
| Specific Function
| Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q26.1 |
| SNPs
| CRTC3 |
| Gene Sequence
|
>1860 bp
ATGGCCGCCTCGCCGGGCTCGGGCAGCGCCAACCCGCGGAAGTTCAGTGAGAAGATCGCG
CTGCACACGCAGAGACAGGCCGAGGAGACGCGGGCCTTCGAGCAGCTCATGACCGACCTC
ACCCTGTCGCGGGTTCAATTTCAGAAGCTTCAGCAACTGCGCCTTACACAGTACCATGGA
GGATCCTTACCAAATGTGAGCCAGCTGCGGAGCAGTGCGTCAGAGTTTCAGCCGTCATTT
CACCAAGCTGATAATGTTCGGGGAACCCGCCATCACGGGCTGGTGGAGAGGCCATCCAGG
AACCGCTTCCACCCCCTCCACCGAAGGTCTGGGGACAAGCCAGGGCGACAATTTGATGGT
AGTGCTTTTGGAGCCAATTATTCCTCACAGCCTCTGGATGAGAGTTGGCCAAGGCAGCAG
CCTCCTTGGAAAGACGAAAAGCATCCTGGGTTCAGGCTGACATCTGCACTTAACAGGACC
AATTCTGATTCTGCTCTTCACACGAGTGCTCTGAGTACCAAGCCCCAGGACCCCTATGGA
GGAGGGGGCCAGTCGGCCTGGCCTGCCCCATACATGGGTTTCTGTGATGGTGAGAATAAT
GGACATGGGGAAGTAGCATCTTTCCCTGGCCCATTGAAAGAAGAGAATCTGTTAAATGTT
CCGAAGCCACTGCCAAAACAACTGTGGGAGACCAAGGAGATTCAGTCCCTGTCAGGACGC
CCTCGATCCTGTGATGTTGGAGGTGGCAATGCTTTTCCACATAATGGTCAAAACCTAGGC
CTCTCACCCTTCTTGGGGACCTTGAACACTGGAGGGTCATTGCCAGATCTAACCAACCTC
CACTACTCGACACCCCTGCCAGCCTCCCTGGACACCACCGACCACCACTTTGGCAGTATG
AGTGTGGGGAATAGTGTGAACAACATCCCAGCTGCTATGACCCACCTGGGTATAAGAAGC
TCCTCTGGTCTCCAGAGTTCTCGGAGTAACCCCTCCATCCAAGCCACGCTCAATAAGACT
GTGCTTTCCTCTTCCTTAAATAACCACCCACAGACATCTGTTCCCAACGCATCTGCTCTT
CACCCTTCGCTCCGTCTGTTTTCCCTTAGCAACCCATCTCTTTCCACCACAAACCTGAGC
GGCCCGTCTCGGCGTCGGCAGCCTCCCGTCAGCCCTCTCACGCTTTCTCCTGGCCCTGAA
GCACATCAAGGTTTCAGCAGACAGCTGTCTTCAACCAGCCCACTGGCCCCATATCCTACC
TCCCAGATGGTGTCCTCAGACCGAAGCCAACTTTCCTTTCTGCCCACAGAAGCTCAAGCC
CAGGTGTCGCCGCCACCCCCTTACCCTGCACCCCAGGAGCTCACCCAGCCCCTCCTGCAG
CAGCCCCGCGCCCCTGAGGCCCCTGCCCAGCAGCCCCAGGCAGCCTCCTCACTGCCACAG
TCAGACTTTCAGCTTCTCCCGGCCCAGGGCTCATCTTTGACCAACTTCTTCCCAGATGTG
GGTTTTGACCAGCAGTCCATGAGGCCAGGCCCTGCCTTTCCTCAACAGGTGCCTCTGGTG
CAACAAGGTTCCCGAGAACTGCAGGACTCTTTTCATTTGAGACCAAGCCCGTATTCCAAC
TGCGGGAGTCTCCCGAACACCATCCTGCCAGAAGACTCCAGCACCAGCCTGTTCAAAGAC
CTCAACAGTGCGCTGGCAGGCCTGCCTGAGGTCAGCCTGAACGTGGACACTCCATTTCCA
CTGGAAGAGGAGCTGCAGATTGAACCCCTGAGCCTGGACGGACTCAACATGTTAAGTGAC
TCCAGCATGGGCCTGCTGGACCCCTCTGTTGAAGAGACGTTTCGAGCTGACAGACTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 619 |
| Molecular Weight
| 66958.7 |
| Theoretical pI
| 6.83 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>CREB-regulated transcription coactivator 3
MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHG
GSLPNVSQLRSSASEFQPSFHQADNVRGTRHHGLVERPSRNRFHPLHRRSGDKPGRQFDG
SAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYG
GGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGR
PRSCDVGGGNAFPHNGQNLGLSPFLGTLNTGGSLPDLTNLHYSTPLPASLDTTDHHFGSM
SVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNHPQTSVPNASAL
HPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPT
SQMVSSDRSQLSFLPTEAQAQVSPPPPYPAPQELTQPLLQQPRAPEAPAQQPQAASSLPQ
SDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQVPLVQQGSRELQDSFHLRPSPYSN
CGSLPNTILPEDSSTSLFKDLNSALAGLPEVSLNVDTPFPLEEELQIEPLSLDGLNMLSD
SSMGLLDPSVEETFRADRL
|
| External Links |
|---|
| GenBank ID Protein
| 110431354 |
| UniProtKB/Swiss-Prot ID
| Q6UUV7 |
| UniProtKB/Swiss-Prot Entry Name
| CRTC3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_022769.3 |
| GeneCard ID
| CRTC3 |
| GenAtlas ID
| CRTC3 |
| HGNC ID
| HGNC:26148 |
| References |
|---|
| General References
| Not Available |