Showing Protein Cyclic AMP-responsive element-binding protein 3-like protein 1 (CDBP03333)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP03333
Secondary Accession Numbers Not Available
Name Cyclic AMP-responsive element-binding protein 3-like protein 1
Description Not Available
Synonyms
  1. OASIS
  2. Old astrocyte specifically-induced substance
  3. Processed cyclic AMP-responsive element-binding protein 3-like protein 1
  4. cAMP-responsive element-binding protein 3-like protein 1
Gene Name CREB3L1
Protein Type Transcription Factor
Biological Properties
General Function Involved in sequence-specific DNA binding transcription factor activity
Specific Function Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
protein binding
nucleic acid binding
dna binding
protein dimerization activity
sequence-specific dna binding
sequence-specific dna binding transcription factor activity
Process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
Cellular Location
  1. Processed cyclic AMP-responsive element- binding protein 3-like protein 1:Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11p11.2
SNPs CREB3L1
Gene Sequence 
>1560 bp
ATGGACGCCGTCTTGGAACCCTTCCCGGCCGACAGGCTGTTCCCCGGATCCAGCTTCCTG
GACTTGGGGGATCTGAACGAGTCGGACTTCCTCAACAATGCGCACTTTCCTGAGCACCTG
GACCACTTTACGGAGAACATGGAGGACTTCTCCAATGACCTGTTCAGCAGCTTCTTTGAT
GACCCTGTGCTGGATGAGAAGAGCCCTCTATTGGACATGGAACTGGACTCCCCTACGCCA
GGCATCCAGGCGGAGCACAGCTACTCCCTGAGCGGCGACTCAGCGCCCCAGAGCCCCCTT
GTGCCCATCAAGATGGAGGACACCACCCAAGATGCAGAGCATGGAGCATGGGCGCTGGGA
CACAAACTGTGCTCCATCATGGTGAAGCAGGAGCAGAGCCCGGAGCTGCCCGTGGACCCT
CTGGCTGCCCCCTCGGCCATGGCTGCCGCGGCCGCCATGGCCACCACCCCGCTGCTGGGC
CTCAGCCCCTTGTCCAGGCTGCCCATCCCCCACCAGGCCCCGGGAGAGATGACTCAGCTG
CCAGTGATCAAAGCAGAGCCTCTGGAGGTGAACCAGTTCCTCAAAGTGACACCGGAGGAC
CTGGTGCAGATGCCTCCGACGCCCCCCAGCAGCCATGGCAGTGACAGCGACGGCTCCCAG
AGTCCCCGCTCTCTGCCCCCCTCCAGCCCTGTCAGGCCCATGGCGCGCTCCTCCACGGCC
ATCTCCACCTCCCCACTCCTCACTGCCCCTCACAAATTACAGGGGACATCAGGGCCACTG
CTCCTGACAGAGGAGGAGAAGCGGACCCTGATTGCTGAGGGCTACCCCATCCCCACAAAA
CTCCCCCTCACCAAAGCCGAGGAGAAGGCCTTGAAGAGAGTCCGGAGGAAAATCAAGAAC
AAGATCTCAGCCCAGGAGAGCCGTCGTAAGAAGAAGGAGTATGTGGAGTGTCTAGAAAAG
AAGGTGGAGACATTTACATCTGAGAACAATGAACTGTGGAAGAAGGTGGAGACCCTGGAG
AATGCCAACAGGACCCTGCTCCAGCAGCTGCAGAAACTCCAGACTCTGGTCACCAACAAG
ATCTCCAGACCTTACAAGATGGCCGCCACCCAGACTGGGACCTGCCTCATGGTGGCAGCC
TTGTGCTTTGTTCTGGTGCTGGGCTCCCTCGTGCCCTGCCTTCCCGAGTTCTCCTCCGGC
TCCCAGACTGTGAAGGAAGACCCCCTGGCCGCAGACGGCGTCTACACGGCCAGCCAGATG
CCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGC
ACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAG
CAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAG
TACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCAC
TCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAG
Protein Properties
Number of Residues 519
Molecular Weight 57004.8
Theoretical pI 4.81
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["375-395"]
Protein Sequence 
>Cyclic AMP-responsive element-binding protein 3-like protein 1
MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFSNDLFSSFFD
DPVLDEKSPLLDMELDSPTPGIQAEHSYSLSGDSAPQSPLVPIKMEDTTQDAEHGAWALG
HKLCSIMVKQEQSPELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPGEMTQL
PVIKAEPLEVNQFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTA
ISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKN
KISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTLLQQLQKLQTLVTNK
ISRPYKMAATQTGTCLMVAALCFVLVLGSLVPCLPEFSSGSQTVKEDPLAADGVYTASQM
PSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTK
YLSEAWPKDGGNGTSPDFSHSKEWFHDRDLGPNTTIKLS
GenBank ID Protein 21668502
UniProtKB/Swiss-Prot ID Q96BA8
UniProtKB/Swiss-Prot Entry Name CR3L1_HUMAN
PDB IDs Not Available
GenBank Gene ID AB063321
GeneCard ID CREB3L1
GenAtlas ID CREB3L1
HGNC ID HGNC:18856
References
General References Not Available