Cannabis Compound Database: Showing Protein Cyclic AMP-dependent transcription factor ATF-3 (CDBP03327)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP03327

Secondary Accession Numbers

Not Available

Name

Cyclic AMP-dependent transcription factor ATF-3

Description

Not Available

Synonyms

Activating transcription factor 3
cAMP-dependent transcription factor ATF-3

Gene Name

ATF3

Protein Type

Transcription Factor

Biological Properties

General Function

Involved in sequence-specific DNA binding transcription factor activity

Specific Function

This protein binds the cAMP response element (CRE) (consensus:5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters

GO Classification

Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
protein binding
nucleic acid binding
dna binding
protein dimerization activity
sequence-specific dna binding
sequence-specific dna binding transcription factor activity
Process
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
biological regulation

Cellular Location

Nucleus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1q32.3

SNPs

ATF3

Gene Sequence

>546 bp
ATGATGCTTCAACACCCAGGCCAGGTCTCTGCCTCGGAAGTGAGTGCTTCTGCCATCGTC
CCCTGCCTGTCCCCTCCTGGGTCACTGGTGTTTGAGGATTTTGCTAACCTGACGCCCTTT
GTCAAGGAAGAGCTGAGGTTTGCCATCCAGAACAAGCACCTCTGCCACCGGATGTCCTCT
GCGCTGGAATCAGTCACTGTCAGCGACAGACCCCTCGGGGTGTCCATCACAAAAGCCGAG
GTAGCCCCTGAAGAAGATGAAAGGAAAAAGAGGCGACGAGAAAGAAATAAGATTGCAGCT
GCAAAGTGCCGAAACAAGAAGAAGGAGAAGACGGAGTGCCTGCAGAAAGAGTCGGAGAAG
CTGGAAAGTGTGAATGCTGAACTGAAGGCTCAGATTGAGGAGCTCAAGAACGAGAAGCAG
CATTTGATATACATGCTCAACCTTCATCGGCCCACGTGTATTGTCCGGGCTCAGAATGGG
AGGACTCCAGAAGATGAGAGAAACCTCTTTATCCAACAGATAAAAGAAGGAACATTGCAG
AGCTAA

Protein Properties

Number of Residues

181

Molecular Weight

20575.4

Theoretical pI

8.76

Pfam Domain Function

bZIP_1 (PF00170 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Cyclic AMP-dependent transcription factor ATF-3
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS
ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK
LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ
S

External Links

GenBank ID Protein

37574508

UniProtKB/Swiss-Prot ID

P18847

UniProtKB/Swiss-Prot Entry Name

ATF3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AY426987

GeneCard ID