| Identification |
|---|
| HMDB Protein ID
| CDBP03324 |
| Secondary Accession Numbers
| Not Available |
| Name
| Agouti-signaling protein |
| Description
| Not Available |
| Synonyms
|
- ASP
- Agouti switch protein
|
| Gene Name
| ASIP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hormone-mediated signaling pathway |
| Specific Function
| Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes |
| GO Classification
|
| Component |
| extracellular region |
| Process |
| signaling |
| signaling pathway |
| hormone-mediated signaling pathway |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q11.2-q12 |
| SNPs
| ASIP |
| Gene Sequence
|
>399 bp
ATGGATGTCACCCGCTTACTCCTGGCCACCCTGCTGGTCTTCCTCTGCTTCTTCACTGCC
AACAGCCACCTGCCACCTGAGGAGAAGCTCCGAGATGACAGGAGCCTGAGAAGCAACTCC
TCTGTGAACCTACTGGATGTCCCTTCTGTCTCTATTGTGGCGCTGAACAAGAAATCCAAA
CAGATCGGCAGAAAAGCAGCAGAAAAGAAAAGATCTTCTAAGAAGGAGGCTTCGATGAAG
AAAGTGGTGCGGCCCCGGACCCCCCTATCTGCGCCCTGCGTGGCCACCCGCAACAGCTGC
AAGCCGCCGGCACCCGCCTGCTGCGACCCGTGCGCCTCCTGCCAGTGCCGCTTCTTCCGC
AGCGCCTGCTCCTGCCGCGTGCTCAGCCTCAACTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 132 |
| Molecular Weight
| 14514.9 |
| Theoretical pI
| 10.34 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Agouti-signaling protein
MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSK
QIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFR
SACSCRVLSLNC
|
| External Links |
|---|
| GenBank ID Protein
| 8953446 |
| UniProtKB/Swiss-Prot ID
| P42127 |
| UniProtKB/Swiss-Prot Entry Name
| ASIP_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AL035458 |
| GeneCard ID
| ASIP |
| GenAtlas ID
| ASIP |
| HGNC ID
| HGNC:745 |
| References |
|---|
| General References
| Not Available |