| Identification |
|---|
| HMDB Protein ID
| CDBP03321 |
| Secondary Accession Numbers
| Not Available |
| Name
| A-kinase anchor protein 2 |
| Description
| Not Available |
| Synonyms
|
- AKAP-2
- AKAP-KL
- PRKA2
- Protein kinase A-anchoring protein 2
|
| Gene Name
| AKAP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in enzyme binding |
| Specific Function
| Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q31.3 |
| SNPs
| AKAP2 |
| Gene Sequence
|
>2580 bp
ATGGAAATTGAGGTGTCTGTTGCAGAATGTAAAAGTGTTCCTGGAATCACCTCTACCCCA
CATCCCATGGACCATCCCTCCGCTTTCTATTCACCCCCGCATAATGGCCTCCTTACTGAT
CACCACGAATCCCTGGATAATGATGTTGCCAGAGAGATCCGCTATCTAGATGAGGTGCTA
GAGGCCAACTGCTGTGATTCTGCTGTGGATGGAACGTACAATGGAACATCCTCCCCAGAG
CCTGGTGCAGTGGTTCTGGTGGGCGGCCTAAGCCCCCCTGTCCACGAGGCGACCCAGCCA
GAACCCACTGAAAGAACAGCTAGCCGGCAGGCACCTCCTCACATCGAGCTCAGTAATAGC
AGCCCTGACCCCATGGCAGAGGCAGAAAGAACAAATGGCCATTCCCCCAGCCAGCCTAGA
GATGCGCTGGGGGACAGCCTGCAGGTGCCTGTCAGCCCCAGCTCCACAACCAGCTCACGG
TGTTCTTCCCGAGATGGAGAGTTCACTCTCACCACACTGAAAAAGGAGGCCAAGTTTGAG
CTGCGTGCCTTCCATGAGGACAAGAAGCCCTCCAAGCTCTTTGAGGATGACGAGCATGAG
AAAGAACAATACTGCATTAGAAAAGTGAGGCCTTCAGAGGAGATGCTGGAGCTGGAAAAG
GAGAGGAGAGAGCTCATCCGCAGCCAGGCCGTCAAGAAGAATCCTGGCATTGCAGCAAAA
TGGTGGAATCCCCCGCAGGAAAAAACCATCGAGGAGCAGCTGGACGAGGAACATCTGGAG
TCGCACAAAAAGTACAAGGAGCGCAAAGAGAGAAGGGCACAGCAGGAACAGTTGCTGCTG
CAGCAGCAGTTACAGCAGCAGCAGCAGCAGCCCCCATCGCAGCTCTGCACAGCCCCTGCC
TCTTCTCATGAACGCGCAAGCATGATTGACAAAGCAAAGGAGGACATTGTCACAGAGCAG
ATAGATTTCTCTGCTGCTCGCAAACAATTTCAGCTGATGGAGAATTCCAGGCAAGCGGTG
GCCAAGGGCCAGAGTACACCCAGGCTGTTCTCCATCAAGCCTTTCTACAGGCCTCTGGGG
TCAGTCAACTCAGACAAGCCACTGACTAATCCGAGACCACCTTCTGTCGGGGGACCTCCA
GAAGACAGTGGTGCCTCAGCCGCCAAGGGACAGAAATCCCCCGGTGCCCTGGAGACCCCA
TCGGCAGCAGGAAGCCAGGGCAACACAGCCTCTCAGGGGAAGGAAGGGCCCTACAGCGAG
CCTTCTAAACGTGGGCCCTTATCTAAACTGTGGGCTGAGGATGGAGAATTTACGAGCGCC
CGGGCTGTCCTCACTGTGGTCAAGGATGATGACCATGGGATTTTGGATCAGTTCTCAAGA
TCTGTCAATGTCTCCTTGACCCAAGAGGAGCTTGACTCTGGTCTGGACGAATTGTCGGTG
AGGTCTCAGGATACCACAGTCCTGGAGACCCTATCCAATGATTTCAGCATGGACAACATC
AGTGACAGCGGGGCATCCAATGAGACAACCAATGCCCTCCAGGAAAATTCACTGGCTGAT
TTTTCTCTGCCCCAGACACCACAAACTGACAACCCCTCAGAGGGCCGAGGAGAAGGCGTC
TCCAAGTCATTTAGTGATCATGGTTTCTATTCCCCTTCCTCCACGCTGGGGGACTCTCCG
TTGGTTGATGACCCCTTGGAGTATCAGGCTGGCCTCCTGGTGCAGAATGCCATTCAACAA
GCCATAGCCGAGCAGGTGGATAAAGCTGTGTCCAAAACCAGCAGGGATGGAGCAGAGCAA
CAGGGACCTGAAGCGACTGTAGAGGAAGCTGAAGCTGCGGCTTTCGGCTCAGAAAAGCCT
CAGAGCATGTTTGAGCCACCTCAGGTGTCTTCTCCTGTTCAAGAGAAAAGGGATGTATTA
CCAAAGATTCTGCCTGCTGAAGACAGGGCGCTCAGGGAAAGGGGGCCCCCCCAGCCACTG
CCAGCTGTGCAGCCCAGTGGCCCGATTAACATGGAGGAGACCAGGCCCGAAGGAAGCTAT
TTCAGCAAGTACTCGGAGGCAGCTGAGCTGAGAAGCACAGCCTCCCTCCTGGCCACTCAA
GAATCTGACGTGATGGTTGGGCCTTTCAAGCTGAGGTCCAGGAAACAGCGGACTTTGTCC
ATGATTGAGGAAGAGATCCGAGCAGCTCAGGAAAGGGAAGAGGAGCTGAAGAGGCAGAGA
CAAGTCTTGCAGAGTACGCAGAGCCCCAGGACAAAGAATGCCCCATCGCTGCCCTCCAGA
ACATGCTACAAAACTGCTCCAGGGAAAATAGAGAAAGTCAAACCTCCTCCATCCCCCACC
ACTGAAGGCCCCAGCTTGCAGCCTGACTTAGCCCCTGAAGAGGCTGCCGGAACCCAGCGG
CCCAAGAATCTGATGCAGACCCTCATGGAAGACTATGAGACACACAAATCTAAAAGGCGC
GAGAGAATGGATGATAGTAGTGTCCTCGAGGCCACACGGGTTAATCGAAGAAAGAGCGCA
CTGGCTTTGCGCTGGGAAGCAGGGATCTATGCCAACCAGGAGGAAGAAGACAACGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 859 |
| Molecular Weight
| 94659.7 |
| Theoretical pI
| 4.76 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>A-kinase anchor protein 2
MEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVL
EANCCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNS
SPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTLKKEAKFE
LRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAK
WWNPPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPA
SSHERASMIDKAKEDIVTEQIDFSAARKQFQLMENSRQAVAKGQSTPRLFSIKPFYRPLG
SVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSE
PSKRGPLSKLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSV
RSQDTTVLETLSNDFSMDNISDSGASNETTNALQENSLADFSLPQTPQTDNPSEGRGEGV
SKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQ
QGPEATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPL
PAVQPSGPINMEETRPEGSYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLS
MIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPT
TEGPSLQPDLAPEEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSVLEATRVNRRKSA
LALRWEAGIYANQEEEDNE
|
| External Links |
|---|
| GenBank ID Protein
| 194390790 |
| UniProtKB/Swiss-Prot ID
| Q9Y2D5 |
| UniProtKB/Swiss-Prot Entry Name
| AKAP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK300427 |
| GeneCard ID
| AKAP2 |
| GenAtlas ID
| AKAP2 |
| HGNC ID
| HGNC:372 |
| References |
|---|
| General References
| Not Available |