| Identification |
|---|
| HMDB Protein ID
| CDBP03317 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein Z-dependent protease inhibitor |
| Description
| Not Available |
| Synonyms
|
- PZ-dependent protease inhibitor
- PZI
- Serpin A10
|
| Gene Name
| SERPINA10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in serine-type endopeptidase inhibitor activity |
| Specific Function
| Inhibits factor Xa activity in the presence of protein Z, calcium and phospholipid |
| GO Classification
|
| Function |
| enzyme regulator activity |
| enzyme inhibitor activity |
| peptidase inhibitor activity |
| endopeptidase inhibitor activity |
| serine-type endopeptidase inhibitor activity |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q32.13 |
| SNPs
| SERPINA10 |
| Gene Sequence
|
>1335 bp
ATGAAGGTGGTGCCAAGTCTCCTGCTCTCCGTCCTCCTGGCACAGGTGTGGCTGGTACCC
GGCTTGGCCCCCAGTCCTCAGTCGCCAGAGACCCCAGCCCCTCAGAACCAGACCAGCAGG
GTAGTGCAGGCTCCCAAGGAGGAAGAGGAAGATGAGCAGGAGGCCAGCGAGGAGAAGGCC
AGTGAGGAAGAGAAAGCCTGGCTGATGGCCAGCAGGCAGCAGCTTGCCAAGGAGACTTCA
AACTTCGGATTCAGCCTGCTGCGAAAGATCTCCATGAGGCACGATGGCAACATGGTCTTC
TCTCCATTTGGCATGTCCTTGGCCATGACAGGCTTGATGCTGGGGGCCACAGGGCCGACT
GAAACCCAGATCAAGAGAGGGCTCCACTTGCAGGCCCTGAAGCCCACCAAGCCCGGGCTC
CTGCCTTCCCTCTTTAAGGGACTCAGAGAGACCCTCTCCCGCAACCTGGAACTGGGCCTC
ACACAGGGGAGTTTTGCCTTCATCCACAAGGATTTTGATGTCAAAGAGACTTTCTTCAAT
TTATCCAAGAGGTATTTTGATACAGAGTGCGTGCCTATGAATTTTCGCAATGCCTCACAG
GCCAAAAGGCTCATGAATCATTACATTAACAAAGAGACTCGGGGGAAAATTCCCAAACTG
TTTGATGAGATTAATCCTGAAACCAAATTAATTCTTGTGGATTACATCTTGTTCAAAGGG
AAATGGTTGACCCCATTTGACCCTGTCTTCACCGAAGTCGACACTTTCCACCTGGACAAG
TACAAGACCATTAAGGTGCCCATGATGTACGGTGCAGGCAAGTTTGCCTCCACCTTTGAC
AAGAATTTTCGTTGTCATGTCCTCAAACTGCCCTACCAAGGAAATGCCACCATGCTGGTG
GTCCTCATGGAGAAAATGGGTGACCACCTCGCCCTTGAAGACTACCTGACCACAGACTTG
GTGGAGACATGGCTCAGAAACATGAAAACCAGAAACATGGAAGTTTTCTTTCCGAAGTTC
AAGCTAGATCAGAAGTATGAGATGCATGAGCTGCTTAGGCAGATGGGAATCAGAAGAATC
TTCTCACCCTTTGCTGACCTTAGTGAACTCTCAGCTACTGGAAGAAATCTCCAAGTATCC
AGGGTTTTACAAAGAACAGTGATTGAAGTTGATGAAAGGGGCACTGAGGCAGTGGCAGGA
ATCTTGTCAGAAATTACTGCTTATTCCATGCCTCCTGTCATCAAAGTGGACCGGCCATTT
CATTTCATGATCTATGAAGAAACCTCTGGAATGCTTCTGTTTCTGGGCAGGGTGGTGAAT
CCGACTCTCCTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 444 |
| Molecular Weight
| 50706.6 |
| Theoretical pI
| 8.58 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein Z-dependent protease inhibitor
MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKA
SEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPT
ETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFN
LSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKG
KWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLV
VLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRI
FSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPF
HFMIYEETSGMLLFLGRVVNPTLL
|
| External Links |
|---|
| GenBank ID Protein
| 5834412 |
| UniProtKB/Swiss-Prot ID
| Q9UK55 |
| UniProtKB/Swiss-Prot Entry Name
| ZPI_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF181467 |
| GeneCard ID
| SERPINA10 |
| GenAtlas ID
| SERPINA10 |
| HGNC ID
| HGNC:15996 |
| References |
|---|
| General References
| Not Available |