| Identification |
|---|
| HMDB Protein ID
| CDBP03312 |
| Secondary Accession Numbers
| Not Available |
| Name
| Vesicle-associated membrane protein 4 |
| Description
| Not Available |
| Synonyms
|
- VAMP-4
|
| Gene Name
| VAMP4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in vesicle-mediated transport |
| Specific Function
| Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Process |
| establishment of localization |
| transport |
| vesicle-mediated transport |
|
| Cellular Location
|
- Golgi apparatus
- trans-Golgi network membrane
- Single-pass type IV membrane protein (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q24-q25 |
| SNPs
| VAMP4 |
| Gene Sequence
|
>426 bp
ATGCCTCCCAAGTTTAAGCGCCACCTCAATGATGATGATGTCACAGGTTCTGTGAAAAGT
GAAAGGAGAAATCTTTTGGAAGATGATTCAGATGAAGAAGAGGACTTTTTTCTAAGGGGA
CCATCTGGACCAAGATTTGGACCTAGAAATGATAAAATTAAGCATGTTCAGAATCAAGTG
GATGAAGTTATTGATGTCATGCCAGAAAATATTACAAAGGTAATTGAGAGAGGGGAGAGA
CTAGATGAACTACAGGACAAATCAGAAAGCTTATCGGATAATGCAACAGCTTTTAGCAAC
AGATCCAAACAACTTCGAAGGCAAATGTGGTGGCGTGGATGCAAAATAAAAGCCATCATG
GCTTTGGTTGCTGCTATCCTTTTGCTAGTGATTATCATTCTTATAGTCATGAAATACCGT
ACTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 141 |
| Molecular Weight
| 16396.7 |
| Theoretical pI
| 7.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Vesicle-associated membrane protein 4
MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQV
DEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIM
ALVAAILLLVIIILIVMKYRT
|
| External Links |
|---|
| GenBank ID Protein
| 3248920 |
| UniProtKB/Swiss-Prot ID
| O75379 |
| UniProtKB/Swiss-Prot Entry Name
| VAMP4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF044310 |
| GeneCard ID
| VAMP4 |
| GenAtlas ID
| VAMP4 |
| HGNC ID
| HGNC:12645 |
| References |
|---|
| General References
| Not Available |