| Identification |
|---|
| HMDB Protein ID
| CDBP03311 |
| Secondary Accession Numbers
| Not Available |
| Name
| Urotensin-2 receptor |
| Description
| Not Available |
| Synonyms
|
- G-protein coupled receptor 14
- UR-2-R
- UR-II-R
- Urotensin II receptor
|
| Gene Name
| UTS2R |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| urotensin ii receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| receptor activity |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q25.3 |
| SNPs
| UTS2R |
| Gene Sequence
|
>1170 bp
ATGGCGCTGACCCCCGAGTCCCCGAGCAGCTTCCCTGGGCTGGCCGCCACCGGCAGCTCT
GTGCCGGAGCCGCCTGGCGGCCCCAACGCAACCCTCAACAGCTCCTGGGCCAGCCCGACC
GAGCCCAGCTCCCTGGAGGACCTGGTGGCCACGGGCACCATTGGGACTCTGCTGTCGGCC
ATGGGCGTGGTGGGCGTGGTGGGCAACGCCTACACGCTGGTGGTCACCTGCCGCTCCCTG
CGTGCGGTGGCCTCCATGTACGTCTACGTGGTCAACCTGGCGCTGGCCGACCTGCTGTAC
CTGCTCAGCATCCCCTTCATCGTGGCCACCTACGTCACCAAGGAGTGGCACTTCGGGGAC
GTGGGCTGCCGCGTGCTCTTCGGCCTGGACTTCCTGACCATGCACGCCAGCATCTTCACG
CTGACCGTCATGAGCAGCGAGCGCTACGCTGCGGTGCTGCGGCCGCTGGACACCGTGCAG
CGCCCCAAGGGCTACCGCAAGCTGCTGGCGCTGGGCACCTGGCTGCTGGCGCTGCTGCTG
ACGCTGCCCGTGATGCTGGCCATGCGGCTGGTGCGCCGGGGTCCCAAGAGCCTGTGCCTG
CCCGCCTGGGGCCCGCGCGCCCACCGCGCCTACCTGACGCTGCTCTTCGCCACCAGCATC
GCGGGGCCCGGGCTGCTCATCGGGCTGCTCTACGCGCGCCTGGCCCGCGCCTACCGCCGC
TCGCAGCGCGCCTCCTTCAAGCGGGCCCGGCGGCCGGGGGCGCGCGCGCTGCGCCTGGTG
CTGGGCATCGTGCTGCTCTTCTGGGCCTGCTTCCTGCCCTTCTGGCTGTGGCAGCTGCTC
GCCCAGTACCACCAGGCCCCGCTGGCGCCGCGGACGGCGCGCATCGTCAACTACCTGACC
ACCTGCCTCACCTACGGCAACAGCTGCGCCAACCCCTTCCTCTACACGCTGCTCACCAGG
AACTACCGCGACCACCTGCGCGGCCGCGTGCGGGGCCCGGGCAGCGGGGGAGGCCGGGGG
CCCGTTCCCTCCCTGCAGCCCCGCGCCCGCTTCCAGCGCTGTTCGGGCCGCTCCCTGTCT
TCCTGCAGCCCACAGCCCACTGACAGCCTCGTGCTGGCCCCAGCGGCCCCGGCCCGACCT
GCGCCCGAGGGTCCCAGGGCCCCGGCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 389 |
| Molecular Weight
| 42129.9 |
| Theoretical pI
| 11.06 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["55-77", "88-113", "125-146", "168-186", "210-232", "259-284", "298-318"]
|
| Protein Sequence
|
>Urotensin-2 receptor
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
|
| External Links |
|---|
| GenBank ID Protein
| 5902616 |
| UniProtKB/Swiss-Prot ID
| Q9UKP6 |
| UniProtKB/Swiss-Prot Entry Name
| UR2R_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF140631 |
| GeneCard ID
| UTS2R |
| GenAtlas ID
| UTS2R |
| HGNC ID
| HGNC:4468 |
| References |
|---|
| General References
| Not Available |