| Identification |
|---|
| HMDB Protein ID
| CDBP03303 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tau-tubulin kinase 1 |
| Description
| Not Available |
| Synonyms
|
- Brain-derived tau kinase
|
| Gene Name
| TTBK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase activity |
| Specific Function
| Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| Process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
| phosphorus metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p21.1 |
| SNPs
| TTBK1 |
| Gene Sequence
|
>3966 bp
ATGCAGTGCCTAGCGGCCGCCCTTAAGGACGAAACCAACATGAGTGGGGGAGGGGAGCAG
GCCGACATCCTGCCGGCCAACTACGTGGTCAAGGATCGCTGGAAGGTGCTGAAAAAGATC
GGGGGCGGGGGCTTTGGTGAGATCTACGAGGCCATGGACCTGCTGACCAGGGAGAATGTG
GCCCTCAAGGTGGAGTCAGCCCAGCAGCCCAAGCAGGTCCTCAAGATGGAGGTGGCCGTG
CTCAAGAAGTTGCAAGGGAAGGACCATGTGTGCAGGTTCATTGGCTGTGGCAGGAACGAG
AAGTTTAACTATGTAGTGATGCAGCTCCAGGGCCGGAACCTGGCCGACCTGCGCCGTAGC
CAGCCGCGAGGCACCTTCACGCTGAGCACCACATTGCGGCTGGGCAAGCAGATCTTGGAG
TCCATCGAGGCCATCCACTCTGTGGGCTTCCTGCACCGTGACATCAAGCCTTCAAACTTT
GCCATGGGCAGGCTGCCCTCCACCTACAGGAAGTGCTATATGCTGGACTTCGGGCTGGCC
CGGCAGTACACCAACACCACGGGGGATGTGCGGCCCCCTCGGAATGTGGCCGGGTTTCGA
GGAACGGTTCGCTATGCCTCAGTCAATGCCCACAAGAACCGGGAGATGGGCCGCCACGAC
GACCTGTGGTCCCTCTTCTACATGCTGGTGGAGTTTGCAGTGGGCCAGCTGCCCTGGAGG
AAGATCAAGGACAAGGAACAGGTAGGGATGATCAAGGAGAAGTATGAGCACCGGATGCTG
CTGAAGCACATGCCGTCAGAGTTCCACCTCTTCCTGGACCACATTGCCAGCCTCGACTAC
TTCACCAAGCCCGACTACCAGTTGATCATGTCAGTGTTTGAGAACAGCATGAAGGAGAGG
GGCATTGCCGAGAATGAGGCCTTTGACTGGGAGAAGGCAGGCACCGATGCCCTCCTGTCC
ACGAGCACCTCTACCCCGCCCCAGCAGAACACCCGGCAGACGGCAGCCATGTTTGGGGTG
GTCAATGTGACGCCAGTGCCTGGGGACCTGCTCCGGGAGAACACCGAGGATGTGCTACAG
GGAGAGCACCTGAGTGACCAGGAGAATGCACCCCCAATTCTGCCCGGGAGGCCCTCTGAG
GGGCTGGGCCCCAGTCCCCACCTTGTCCCCCACCCCGGGGGTCCTGAGGCTGAAGTCTGG
GAGGAGACAGATGTCAACCGGAACAAACTCCGGATCAACATCGGCAAAAGCCCCTGTGTG
GAGGAGGAACAGAGCCGAGGCATGGGGGTCCCCAGCTCCCCAGTGCGTGCCCCCCCAGAC
TCCCCCACAACCCCAGTCCGTTCTCTGCGCTACCGGAGGGTGAACAGCCCTGAGTCAGAA
AGGCTGTCCACGGCGGACGGGCGAGTGGAGCTACCTGAGAGGAGGTCACGGATGGATCTG
CCTGGCTCGCCCTCGCGCCAGGCCTGCTCCTCTCAGCCAGCCCAGATGCTGTCAGTGGAC
ACAGGCCACGCTGACCGACAGGCCAGTGGCCGCATGGACGTGTCAGCCTCTGTGGAGCAG
GAGGCCCTGAGCAACGCCTTCCGCTCGGTGCCGCTGGCTGAGGAGGAGGATTTCGACAGC
AAAGAGTGGGTCATCATCGACAAGGAGACGGAGCTCAAGGACTTCCCTCCAGGGGCTGAG
CCCAGCACATCGGGCACCACGGATGAGGAGCCCGAGGAGCTGCGGCCACTGCCCGAGGAG
GGCGAAGAGCGGCGGCGGCTGGGGGCAGAGCCCACCGTCCGGCCCCGGGGACGCAGCATG
CAGGCGCTGGCGGAGGAGGACCTGCAGCATTTGCCGCCCCAGCCCCTGCCACCCCAGCTG
AGCCAGGGCGATGGCCGTTCCGAGACGTCACAGCCCCCCACGCCTGGCAGCCCTTCCCAC
TCACCCCTGCACTCGGGACCCCGCCCTCGACGGAGAGAGTCGGACCCCACAGGCCCACAG
AGACAGGTGTTCTCCGTGGCGCCCCCATTTGAGGTGAATGGCCTCCCACGAGCTGTGCCT
CTGAGTCTGCCCTACCAGGACTTCAAAAGAGACCTCTCCGATTACCGAGAACGGGCGCGG
TTGCTCAACAGGGTCCGGAGGGTGGGCTTCTCGCACATGCTGCTCACCACCCCCCAGGTC
CCACTGGCTCCTGTTCAGCCTCAGGCTAATGGGAAGGAGGAAGAGGAGGAGGAGGAGGAA
GATGAGGAAGAGGAAGAAGAGGATGAGGAAGAAGAAGAGGAGGAAGAGGAAGAGGAGGAG
GAAGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGCTGCAGCGGCAGTTGCCTTGGGGGAG
GTGCTGGGGCCTCGTAGTGGCTCCAGCAGTGAGGGGAGTGAGAGGAGCACTGACCGGAGC
CAGGAGGGTGCCCCGTCCACGCTGCTGGCAGACGATCAGAAGGAGTCCAGGGGCCGGGCC
TCCATGGCCGATGGGGACCTGGAGCCTGAGGAGGGCTCCAAAACGCTGGTGCTTGTCTCT
CCTGGCGACATGAAGAAGTCGCCCGTCACTGCCGAACTGGCCCCCGACCCCGACCTGGGC
ACCCTGGCTGCCCTCACTCCTCAGCATGAGCGGCCCCAGCCCACGGGCAGCCAGCTGGAC
GTATCTGAGCCAGGCACCCTGTCCTCTGTCCTCAAGTCTGAGCCCAAGCCCCCGGGGCCT
GGGGCAGGGCTGGGGGCCGGGACAGTGACCACAGGGGTCGGGGGCGTGGCAGTCACCTCC
TCACCCTTCACCAAAGTTGAGAGGACCTTTGTGCACATTGCGGAGAAAACCCACCTCAAC
GTCATGTCTTCCGGTGGACAAGCCTTGCGGTCTGAGGAGTTCAGCGCTGGGGGCGAGCTG
GGTCTGGAGCTGGCCTCTGATGGGGGCGCTGTGGAGGAGGGGGCCCGAGCGCCCCTGGAG
AACGGCCTCGCCCTGTCAGGGCTGAATGGGGCTGAGATAGAGGGCTCTGCCCTGTCTGGG
GCCCCCCGGGAAACCCCCTCAGAGATGGCCACAAACTCACTGCCCAATGGCCCGGCCCTT
GCAGACGGGCCAGCCCCGGTGTCCCCGCTGGAGCCAAGCCCTGAGAAAGTGGCCACCATC
TCCCCCAGACGCCATGCTATGCCAGGCTCTCGCCCCAGGAGCCGTATCCCTGTCCTGCTC
TCTGAGGAGGACACGGGCTCGGAGCCCTCAGGCTCACTGTCGGCCAAAGAGCGGTGGAGC
AAGCGGGCTCGGCCGCAGCAGGACCTGGCGCGGCTGGTGATGGAGAAGAGGCAGGGCCGC
CTGCTGTTGCGGCTGGCCTCAGGGGCCTCGTCCTCCTCCAGTGAGGAGCAGCGCCGTGCC
TCTGAGACCCTCTCAGGCACGGGCTCTGAGGAGGACACGCCCGCCTCTGAGCCGGCAGCG
GCCTTGCCCAGGAAGAGCGGGAGGGCAGCCGCCACCAGGAGCCGGATTCCCCGCCCCATT
GGCCTCCGCATGCCCATGCCTGTTGCAGCCCAGCAGCCCGCCAGCAGATCCCATGGCGCG
GCCCCAGCATTGGACACAGCCATCACCAGCAGGCTCCAGCTGCAGACGCCCCCAGGGTCG
GCCACTGCTGCTGACCTCCGCCCCAAACAACCTCCTGGCCGCGGCCTGGGCCCAGGGCGA
GCCCAAGCCGGAGCCAGGCCCCCAGCGCCGCGCAGCCCGCGCCTCCCCGCGTCCACATCC
GCCGCGCGCAATGCCAGCGCGTCCCCCCGGAGCCAGTCCCTGTCCCGCAGAGAGAGCCCC
TCCCCCTCGCACCAGGCCCGGCCCGGGGTCCCCCCGCCCCGGGGCGTCCCGCCGGCCCGG
GCCCAGCCTGATGGCACCCCCTCCCCCGGGGGCTCCAAGAAAGGACCCAGAGGGAAACTC
CAGGCTCAGCGCGCAACAACCAAAGGCCGGGCAGGAGGCGCGGAGGGCCGGGCTGGGGCC
AGATAA
|
| Protein Properties |
|---|
| Number of Residues
| 1321 |
| Molecular Weight
| 142735.8 |
| Theoretical pI
| 5.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tau-tubulin kinase 1
MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENV
ALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRS
QPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA
RQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR
KIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKER
GIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQ
GEHLSDQENAPPILPGRPSEGLGPSPHLVPHPGGPEAEVWEETDVNRNKLRINIGKSPCV
EEEQSRGMGVPSSPVRAPPDSPTTPVRSLRYRRVNSPESERLSTADGRVELPERRSRMDL
PGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDS
KEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGAEPTVRPRGRSM
QALAEEDLQHLPPQPLPPQLSQGDGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQ
RQVFSVAPPFEVNGLPRAVPLSLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQV
PLAPVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGE
VLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEEGSKTLVLVS
PGDMKKSPVTAELAPDPDLGTLAALTPQHERPQPTGSQLDVSEPGTLSSVLKSEPKPPGP
GAGLGAGTVTTGVGGVAVTSSPFTKVERTFVHIAEKTHLNVMSSGGQALRSEEFSAGGEL
GLELASDGGAVEEGARAPLENGLALSGLNGAEIEGSALSGAPRETPSEMATNSLPNGPAL
ADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWS
KRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAA
ALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSRLQLQTPPGS
ATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESP
SPSHQARPGVPPPRGVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGAEGRAGA
R
|
| External Links |
|---|
| GenBank ID Protein
| 58761548 |
| UniProtKB/Swiss-Prot ID
| Q5TCY1 |
| UniProtKB/Swiss-Prot Entry Name
| TTBK1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_032538.1 |
| GeneCard ID
| TTBK1 |
| GenAtlas ID
| TTBK1 |
| HGNC ID
| HGNC:19140 |
| References |
|---|
| General References
| Not Available |