Showing Protein Transient receptor potential cation channel subfamily M member 3 (CDBP03295)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03295
Secondary Accession Numbers Not Available
Name Transient receptor potential cation channel subfamily M member 3
Description Not Available
Synonyms
  1. LTrpC-3
  2. LTrpC3
  3. Long transient receptor potential channel 3
  4. MLSN2
  5. Melastatin-2
Gene Name TRPM3
Protein Type Receptor
Biological Properties
General Function Involved in ion channel activity
Specific Function Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation
GO Classification
Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
ion transport
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:9
Locus 9q21.12
SNPs TRPM3
Gene Sequence 
>5124 bp
ATGCCAGAGCCGTGGGGGACCGTTTATTTTCTAGGCATTGCTCAGGTTTTCAGTTTCTTG
TTTTCCTGGTGGAATTTGGAAGGGGTCATGAATCAGGCTGATGCTCCTCGACCCCTAAAC
TGGACCATCCGGAAGCTGTGCCACGCAGCCTTTCTTCCATCTGTCAGACTTCTGAAGGCT
CAGAAATCCTGGATAGAAAGAGCATTTTATAAAAGAGAATGTGTCCACATCATACCCAGC
ACCAAAGACCCCCATAGGTGTTGCTGTGGGCGTCTGATAGGCCAGCATGTTGGCCTCACC
CCCAGTATCTCCGTGCTTCAGAATGAGAAAAATGAAAGTCGCCTCTCCCGAAATGACATC
CAGTCTGAAAAGTGGTCCATCAGCAAACACACTCAACTCAGCCCTACGGATGCTTTTGGG
ACCATTGAGTTCCAAGGAGGTGGCCATTCCAACAAAGCCATGTATGTGCGAGTATCTTTT
GATACAAAACCTGATCTCCTCTTACACCTGATGACCAAGGAATGGCAGTTGGAGCTTCCC
AAGCTTCTCATCTCTGTCCATGGGGGCCTGCAGAACTTTGAACTCCAGCCAAAACTCAAG
CAAGTCTTTGGGAAAGGGCTCATCAAAGCAGCAATGACAACTGGAGCGTGGATATTCACT
GGAGGGGTTAACACAGGTGTTATTCGTCATGTTGGCGATGCCTTGAAGGATCATGCCTCT
AAGTCTCGAGGAAAGATATGCACCATAGGTATTGCCCCCTGGGGAATTGTGGAAAACCAG
GAGGACCTCATTGGAAGAGATGTTGTCCGGCCATACCAGACCATGTCCAATCCCATGAGC
AAGCTCACTGTTCTCAACAGCATGCATTCCCACTTCATTCTGGCTGACAACGGGACCACT
GGAAAATATGGAGCAGAGGTGAAACTTCGAAGACAACTGGAAAAGCATATTTCACTCCAG
AAGATAAACACAAGAATCGGTCAAGGTGTTCCTGTGGTGGCACTCATAGTGGAAGGAGGA
CCCAATGTGATCTCGATTGTTTTGGAGTACCTTCGAGACACCCCTCCCGTGCCAGTGGTT
GTCTGTGATGGGAGTGGACGGGCATCGGACATCCTGGCCTTTGGGCATAAATACTCAGAA
GAAGGCGGACTGATAAATGAATCTTTGAGGGACCAGCTGTTGGTGACTATACAGAAGACT
TTCACATACACTCGAACCCAAGCTCAGCATCTGTTCATCATCCTCATGGAGTGCATGAAG
AAGAAGGAATTGATTACGGTATTTCGGATGGGATCAGAAGGACACCAGGACATTGATTTG
GCTATCCTGACAGCTTTACTCAAAGGAGCCAATGCCTCGGCCCCAGACCAACTGAGCTTA
GCTTTAGCCTGGAACAGAGTCGACATCGCTCGCAGCCAGATCTTTATTTACGGGCAACAG
TGGCCGGTGGGATCTCTGGAGCAAGCCATGTTGGATGCCTTAGTTCTGGACAGAGTGGAT
TTTGTGAAATTACTCATAGAGAATGGAGTAAGCATGCACCGTTTTCTCACCATCTCCAGA
CTAGAGGAATTGTACAATACGAGACATGGGCCCTCAAATACATTGTACCACTTGGTCAGG
GATGTCAAAAAGGGGAACCTGCCCCCAGACTACAGAATCAGCCTGATTGACATCGGCCTG
GTGATCGAGTACCTGATGGGCGGGGCTTATCGCTGCAACTACACGCGCAAGCGCTTCCGG
ACCCTCTACCACAACCTCTTCGGCCCCAAGAGGCCCAAAGCCTTGAAACTGCTGGGAATG
GAGGATGATATTCCCTTGAGGCGAGGAAGAAAGACAACCAAGAAACGTGAAGAAGAGGTG
GACATTGACTTGGATGATCCTGAGATCAACCACTTCCCCTTCCCTTTCCATGAGCTCATG
GTGTGGGCTGTTCTCATGAAGCGGCAGAAGATGGCCCTGTTCTTCTGGCAGCACGGTGAG
GAGGCCATGGCCAAGGCCCTGGTGGCCTGCAAGCTCTGCAAAGCCATGGCTCATGAGGCC
TCTGAGAACGACATGGTTGACGACATTTCCCAGGAGCTGAATCACAATTCCAGAGACTTT
GGCCAGCTGGCTGTGGAGCTCCTGGACCAGTCCTACAAGCAGGACGAACAGCTGGCCATG
AAACTGCTGACGTATGAGCTGAAGAACTGGAGCAACGCCACGTGCCTGCAGCTTGCCGTG
GCTGCCAAACACCGCGACTTCATCGCGCACACGTGCAGCCAGATGCTGCTCACCGACATG
TGGATGGGCCGGCTCCGCATGCGCAAGAACTCAGGCCTCAAGGTAATTCTGGGAATTCTA
CTTCCTCCTTCAATTCTCAGCTTGGAGTTCAAGAACAAAGACGACATGCCCTATATGTCT
CAGGCCCAGGAAATCCACCTCCAAGAGAAGGAGGCAGAAGAACCAGAGAAGCCCACAAAG
GAAAAAGAGGAAGAGGACATGGAGCTCACAGCAATGTTGGGACGAAACAACGGGGAGTCC
TCCAGGAAGAAGGATGAAGAGGAAGTTCAGAGCAAGCACCGGTTAATCCCCCTCGGCAGA
AAAATCTATGAATTCTACAATGCACCCATCGTGAAGTTCTGGTTCTACACACTGGCGTAT
ATCGGATACCTGATGCTCTTCAACTATATCGTGTTAGTGAAGATGGAACGCTGGCCGTCC
ACCCAGGAATGGATCGTAATCTCCTATATTTTCACCCTGGGAATAGAAAAGATGAGAGAG
ATTCTGATGTCAGAGCCAGGGAAGTTGCTACAGAAAGTGAAGGTATGGCTGCAGGAGTAC
TGGAATGTCACGGACCTCATCGCCATCCTTCTGTTTTCTGTCGGAATGATCCTTCGTCTC
CAAGACCAGCCCTTCAGGAGTGACGGGAGGGTCATCTACTGCGTGAACATCATTTACTGG
TATATCCGTCTCCTAGACATCTTCGGCGTGAACAAGTATTTGGGCCCGTATGTAATGATG
ATTGGAAAAATGATGATAGACATGATGTACTTTGTCATCATTATGCTGGTGGTTCTGATG
AGCTTTGGGGTCGCCAGGCAAGCCATCCTTTTTCCCAATGAGGAGCCATCATGGAAACTG
GCCAAGAACATCTTCTACATGCCCTATTGGATGATTTATGGGGAAGTGTTTGCGGACCAG
ATAGACCCTCCCTGTGGACAGAATGAGACCCGAGAGGATGGTAAAATAATCCAGCTGCCT
CCCTGCAAGACAGGAGCTTGGATCGTGCCGGCCATCATGGCCTGCTACCTCTTAGTGGCA
AACATCTTGCTGGTCAACCTCCTCATTGCTGTCTTTAACAATACATTTTTTGAAGTAAAA
TCGATATCCAACCAAGTCTGGAAGTTTCAGAGGTATCAGCTCATCATGACTTTCCATGAA
AGGCCAGTTCTGCCCCCACCACTGATCATCTTCAGCCACATGACCATGATATTCCAGCAC
CTGTGCTGCCGATGGAGGAAACACGAGAGCGACCCGGATGAAAGGGACTACGGCCTGAAA
CTCTTCATAACCGATGATGAGCTCAAGAAAGTACATGACTTTGAAGAGCAATGCATAGAA
GAATACTTCAGAGAAAAGGATGATCGGTTCAACTCATCTAATGATGAGAGGATACGGGTG
ACTTCAGAAAGGGTGGAGAACATGTCTATGCGGCTGGAGGAAGTCAACGAGAGAGAGCAC
TCCATGAAGGCTTCACTCCAGACCGTGGACATCCGGCTGGCGCAGCTGGAAGACCTTATC
GGGCGCATGGCCACGGCCCTGGAGCGCCTGACAGGTCTGGAGCGGGCCGAGTCCAACAAA
ATCCGCTCGAGGACCTCGTCAGACTGCACGGACGCCGCCTACATTGTCCGTCAGAGCAGC
TTCAACAGCCAGGAAGGGAACACCTTCAAGCTCCAAGAGAGTATAGACCCTGCAGGTGAG
GAGACCATGTCCCCAACTTCTCCAACCTTAATGCCCCGTATGCGAAGCCATTCTTTCTAT
TCGGTCAATATGAAAGACAAAGGTGGTATAGAAAAGTTGGAAAGTATTTTTAAAGAAAGG
TCCCTGAGCCTACACCGGGCTACTAGTTCCCACTCTGTAGCAAAAGAACCCAAAGCTCCT
GCAGCCCCTGCCAACACCTTGGCCATTGTTCCTGATTCCAGAAGACCATCATCGTGTATA
GACATCTATGTCTCTGCTATGGATGAGCTCCACTGTGATATAGACCCTCTGGACAATTCC
GTGAACATCCTTGGGCTGGGCGAGCCAAGCTTTTCAACTCCAGTACCTTCCACAGCCCCT
TCAAGTAGTGCCTATGCAACACTTGCACCCACAGACAGACCTCCAAGCCGGAGCATTGAT
TTTGAGGACATCACCTCCATGGACACTAGATCTTTTTCTTCAGACTACACCCACCTCCCA
GAATGCCAAAACCCCTGGGACTCAGAGCCTCCGATGTACCACACCATTGAGCGTTCCAAA
AGTAGCCGCTACCTAGCCACCACACCCTTTCTTCTAGAAGAGGCTCCCATTGTGAAATCT
CATAGCTTTATGTTTTCCCCCTCAAGGAGCTATTATGCCAACTTTGGGGTGCCTGTAAAA
ACAGCAGAATACACAAGTATTACAGACTGTATTGACACAAGGTGTGTCAATGCCCCTCAA
GCAATTGCGGACAGAGCTGCCTTCCCTGGAGGTCTTGGAGACAAAGTGGAGGACTTAACT
TGCTGCCATCCAGAGCGAGAAGCAGAACTGAGTCACCCCAGCTCTGACAGTGAGGAGAAT
GAGGCCAAAGGCCGCAGAGCCACCATTGCAATATCCTCCCAGGAGGGTGATAACTCAGAG
AGAACCCTGTCCAACAACATCACTGTTCCCAAGATAGAGCGCGCCAACAGCTACTCGGCA
GAGGAGCCAAGTGCGCCATATGCACACACCAGGAAGAGCTTCTCCATCAGTGACAAACTC
GACAGGCAGCGGAACACAGCAAGCCTGCGAAATCCCTTCCAGAGAAGCAAGTCCTCCAAG
CCGGAGGGCCGAGGGGACAGCCTGTCCATGAGGAGACTGTCCAGAACATCGGCTTTCCAA
AGCTTTGAAAGCAAGCACAACTAA
Protein Properties
Number of Residues 1732
Molecular Weight 197541.2
Theoretical pI 7.11
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["4-24", "795-815", "898-918", "965-985", "996-1016", "1029-1049", "1117-1137"]
Protein Sequence 
>Transient receptor potential cation channel subfamily M member 3
MPEPWGTVYFLGIAQVFSFLFSWWNLEGVMNQADAPRPLNWTIRKLCHAAFLPSVRLLKA
QKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDI
QSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELP
KLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHAS
KSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTT
GKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVAL
IVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLV
TIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAP
DQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRF
LTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYT
RKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFP
FHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNH
NSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQM
LLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP
EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWF
YTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKV
WLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLG
PYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGE
VFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNT
FFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDER
DYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEV
NEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYI
VRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLES
IFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDID
PLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSD
YTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANF
GVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSS
DSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFS
ISDKLDRQRNTASLQNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQSFESKHN
GenBank ID Protein 154091314
UniProtKB/Swiss-Prot ID Q9HCF6
UniProtKB/Swiss-Prot Entry Name TRPM3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001007471
GeneCard ID TRPM3
GenAtlas ID TRPM3
HGNC ID HGNC:17992
References
General References Not Available