| Identification |
|---|
| HMDB Protein ID
| CDBP03290 |
| Secondary Accession Numbers
| Not Available |
| Name
| Short transient receptor potential channel 4 |
| Description
| Not Available |
| Synonyms
|
- Trp-related protein 4
- TrpC4
- hTrp-4
- hTrp4
|
| Gene Name
| TRPC4 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transporter activity |
| ion channel activity |
| cation channel activity |
| calcium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| Process |
| di-, tri-valent inorganic cation transport |
| divalent metal ion transport |
| calcium ion transport |
| establishment of localization |
| transport |
| transmembrane transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Cell membrane
- Membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q13.3 |
| SNPs
| TRPC4 |
| Gene Sequence
|
>2934 bp
ATGGCTCAGTTCTATTACAAAAGAAATGTTAATGCTCCCTATAGAGACCGCATCCCTCTA
AGGATAGTAAGAGCAGAATCAGAACTTTCGCCATCAGAAAAAGCCTACTTGAATGCTGTG
GAAAAGGGAGATTATGCCAGTGTCAAGAAATCCCTAGAGGAAGCTGAAATTTATTTTAAA
ATCAATATTAATTGCATTGATCCTCTCGGAAGAACTGCTCTCCTCATTGCAATTGAAAAT
GAGAACTTGGAGCTCATCGAACTACTCTTAAGCTTTAATGTCTATGTTGGAGATGCTCTA
TTACATGCTATCAGAAAAGAAGTCGTCGGAGCTGTTGAGCTGTTATTGAACCACAAAAAA
CCTAGTGGAGAAAAACAGGTGCCTCCTATACTCCTTGATAAGCAGTTCTCTGAATTCACT
CCAGACATTACACCAATCATTTTGGCAGCCCATACAAATAATTATGAGATAATAAAACTC
TTGGTTCAGAAAGGAGTCTCAGTGCCTCGACCCCACGAGGTCCGCTGTAACTGTGTGGAA
TGCGTGTCCAGTTCAGATGTGGACAGCCTCCGTCACTCACGCTCCAGACTCAACATCTAC
AAGGCCTTGGCCAGTCCCTCTCTCATTGCACTGTCAAGCGAAGATCCTTTTCTCACAGCC
TTTCAGTTAAGTTGGGAACTTCAGGAACTGAGCAAGGTGGAAAATGAATTCAAGTCGGAG
TATGAAGAGCTGTCACGGCAGTGCAAACAATTTGCTAAGGACCTACTGGATCAGACGAGA
AGTTCCAGAGAACTGGAAATCATTCTTAATTACCGAGATGACAATAGTCTCATAGAAGAA
CAAAGTGGAAATGATCTTGCAAGACTAAAATTGGCCATTAAGTACCGTCAAAAAGAGTTT
GTTGCCCAGCCCAATTGTCAACAGCTGCTGGCATCTCGCTGGTACGATGAGTTTCCAGGC
TGGAGGAGAAGACACTGGGCAGTGAAGATGGTGACATGTTTCATAATAGGACTTCTTTTT
CCTGTCTTCTCTGTGTGCTACCTGATAGCTCCCAAAAGCCCACTTGGACTGTTCATCAGG
AAGCCATTTATCAAGTTTATCTGCCACACAGCCTCCTATTTGACTTTTTTGTTCCTGCTG
CTGCTTGCCTCTCAGCACATCGACAGGTCAGACTTGAACAGGCAAGGTCCACCACCAACC
ATCGTCGAGTGGATGATATTACCGTGGGTCCTGGGCTTCATATGGGGAGAAATTAAACAG
ATGTGGGATGGCGGACTTCAGGACTACATCCATGATTGGTGGAATCTAATGGACTTTGTA
ATGAACTCCTTATATTTAGCAACAATCTCCTTGAAAATTGTTGCATTTGTAAAGTACAGT
GCCCTTAATCCACGAGAATCATGGGACATGTGGCATCCCACTCTGGTGGCAGAAGCTTTA
TTTGCTATTGCAAACATCTTCAGTTCTCTGCGTCTGATCTCACTGTTTACTGCAAATTCT
CACCTGGGACCTCTGCAAATATCTCTGGGAAGAATGCTCCTGGACATTTTGAAGTTTCTA
TTCATATACTGCCTTGTGTTGCTAGCATTTGCAAATGGCCTAAATCAATTGTACTTCTAT
TATGAAGAAACGAAAGGGTTAACCTGCAAAGGCATAAGATGTGAAAAGCAGAATAATGCA
TTTTCAACGTTATTTGAGACACTGCAGTCCCTGTTTTGGTCAATATTTGGGCTCATCAAT
TTATATGTGACCAATGTCAAAGCACAGCATGAATTTACTGAGTTTGTTGGTGCCACCATG
TTTGGGACATACAATGTCATCTCTCTGGTTGTTCTACTCAACATGTTAATAGCTATGATG
AATAATTCTTACCAACTGATTGCTGACCATGCAGATATAGAATGGAAATTTGCACGAACA
AAGCTTTGGATGAGTTATTTTGAAGAAGGAGGTACTCTGCCTACTCCCTTCAATGTCATC
CCGAGCCCCAAGTCTCTCTGGTACCTGATCAAATGGATCTGGACACACTTGTGCAAGAAA
AAGATGAGAAGAAAGCCAGAAAGTTTTGGAACAATAGGGAGGCGAGCTGCTGATAACTTG
AGAAGACATCACCAATACCAAGAAGTTATGAGGAACCTGGTGAAGCGATACGTTGCTGCA
ATGATTAGAGATGCTAAAACTGAAGAAGGCCTGACCGAAGAGAACTTTAAGGAACTAAAG
CAAGACATTTCTAGTTTCCGCTTTGAAGTCCTGGGATTACTAAGAGGAAGCAAACTTTCC
ACAATACAATCTGCGAATGCCTCGAAGGAGTCTTCAAATTCGGCAGACTCAGATGAAAAG
AGTGATAGCGAAGGTAATAGCAAGGACAAGAAAAAGAATTTCAGCCTTTTTGATTTAACC
ACCCTGATTCATCCGAGATCAGCAGCAATTGCCTCTGAAAGACATAACATAAGCAATGGC
TCTGCCCTGGTGGTTCAGGAGCCGCCCAGGGAGAAGCAGAGAAAAGTGAATTTTGTGACC
GATATCAAAAACTTTGGGTTATTTCATAGACGATCAAAACAAAATGCTGCTGAGCAAAAT
GCAAACCAAATCTTCTCTGTTTCAGAAGAAGTTGCTCGTCAACAGGCTGCAGGACCACTT
GAGAGAAATATTCAACTGGAATCTCGAGGATTAGCTTCACGGGGTGACCTGAGCATTCCC
GGTCTCAGTGAACAATGTGTGTTAGTAGACCATAGAGAAAGGAATACGGACACACTGGGG
TTACAGGTAGGAAAGAGAGTGTGTCCATTCAAGTCAGAGAAGGTGGTGGTGGAGGACACG
GTTCCTATAATACCAAAGGAGAAACATGCAAAAGAAGAGGACTCTAGTATAGACTATGAT
CTAAACCTCCCAGACACAGTCACCCACGAAGATTACGTGACCACAAGATTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 977 |
| Molecular Weight
| 112099.9 |
| Theoretical pI
| 7.83 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["330-350", "363-383", "437-457", "470-490", "512-532", "600-620"]
|
| Protein Sequence
|
>Short transient receptor potential channel 4
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI
PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAA
MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK
SDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVT
DIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIP
GLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYD
LNLPDTVTHEDYVTTRL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9UBN4 |
| UniProtKB/Swiss-Prot Entry Name
| TRPC4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF063822 |
| GeneCard ID
| TRPC4 |
| GenAtlas ID
| TRPC4 |
| HGNC ID
| HGNC:12336 |
| References |
|---|
| General References
| Not Available |