| Identification |
|---|
| HMDB Protein ID
| CDBP03289 |
| Secondary Accession Numbers
| Not Available |
| Name
| Short transient receptor potential channel 1 |
| Description
| Not Available |
| Synonyms
|
- TRP-1
- Transient receptor protein 1
- TrpC1
|
| Gene Name
| TRPC1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| calcium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| Process |
| di-, tri-valent inorganic cation transport |
| divalent metal ion transport |
| calcium ion transport |
| establishment of localization |
| transport |
| transmembrane transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q23 |
| SNPs
| TRPC1 |
| Gene Sequence
|
>2382 bp
ATGATGGCGGCCCTGTACCCGAGCACGGACCTCTCGGGCGCCTCCTCCTCCTCCCTGCCT
TCCTCTCCATCCTCTTCCTCGCCGAACGAGGTGATGGCGCTGAAGGATGTGCGGGAGGTG
AAGGAGGAGAATACGCTGAATGAGAAGCTTTTCTTGCTGGCGTGCGACAAGGGTGACTAT
TATATGGTTAAAAAGATTTTGGAGGAAAACAGTTCAGGTGACTTGAACATAAATTGCGTA
GATGTGCTTGGGAGAAATGCTGTTACCATAACTATTGAAAACGAAAACTTGGATATACTG
CAGCTTCTTTTGGACTACGGTTGTCAGTCTGCAGATGCACTTTTGGTGGCAATCGACTCT
GAAGTAGTGGGAGCTGTTGATATACTACTTAATCATCGACCAAAACGATCATCAAGACCA
ACTATAGTAAAACTAATGGAACGAATTCAGAATCCTGAGTATTCAACAACTATGGATGTT
GCACCTGTCATTTTAGCTGCTCATCGTAACAACTATGAAATTCTTACAATGCTCTTAAAA
CAGGATGTATCTCTACCCAAGCCCCATGCAGTTGGCTGTGAATGCACATTGTGTTCTGCA
AAAAACAAAAAGGATAGCCTCCGGCATTCCAGGTTTCGTCTTGATATATATCGATGTTTG
GCCAGTCCAGCTCTAATAATGTTAACAGAGGAGGATCCAATTCTGAGAGCATTTGAACTT
AGTGCTGATTTAAAAGAACTAAGTCTTGTGGAGGTGGAATTCAGGAATGATTATGAGGAA
CTAGCCCGGCAATGTAAAATGTTTGCTAAGGATTTACTTGCACAAGCCCGGAATTCTCGT
GAATTGGAAGTTATTCTAAACCATACGTCTAGTGACGAGCCTCTTGACAAACGGGGATTA
TTAGAAGAAAGAATGAATTTAAGTCGTCTAAAACTTGCTATCAAATATAACCAGAAAGAG
TTTGTCTCCCAGTCTAACTGCCAGCAGTTCCTGAACACTGTTTGGTTTGGACAGATGTCG
GGTTACCGACGCAAGCCCACCTGTAAGAAGATAATGACTGTTTTGACAGTAGGCATCTTT
TGGCCAGTTTTGTCACTTTGTTATTTGATAGCTCCCAAATCTCAGTTTGGCAGAATCATT
CACACACCTTTTATGAAATTTATCATTCATGGAGCATCATATTTCACATTTCTGCTGTTG
CTTAATCTATACTCTCTTGTCTACAATGAGGATAAGAAAAACACAATGGGGCCAGCCCTT
GAAAGAATAGACTATCTTCTTATTCTGTGGATTATTGGGATGATTTGGTCAGACATTAAA
AGACTCTGGTATGAAGGGTTGGAAGACTTTTTAGAAGAATCTCGTAATCAACTCAGTTTT
GTCATGAATTCTCTTTATTTGGCAACCTTTGCCCTCAAAGTGGTTGCTCACAACAAGTTT
CATGATTTTGCTGATCGGAAGGATTGGGATGCATTCCATCCTACACTGGTGGCAGAAGGG
CTTTTTGCATTTGCAAATGTTCTAAGTTATCTTCGTCTCTTTTTTATGTATACAACCAGC
TCTATCTTGGGTCCATTACAGATTTCAATGGGACAGATGTTACAAGATTTTGGAAAATTT
CTTGGGATGTTTCTTCTTGTTTTGTTTTCTTTCACAATTGGACTGACACAACTGTATGAT
AAAGGATATACTTCAAAGGAGCAGAAGGACTGTGTAGGCATCTTCTGTGAACAGCAAAGC
AATGATACCTTCCATTCGTTCATTGGCACCTGCTTTGCTTTGTTCTGGTATATTTTCTCC
TTAGCGCATGTGGCAATCTTTGTCACAAGATTTAGCTATGGAGAAGAACTGCAGTCCTTT
GTGGGAGCTGTCATTGTTGGTACATACAATGTCGTGGTTGTGATTGTGCTTACCAAACTG
CTGGTGGCAATGCTTCATAAAAGCTTTCAGTTGATAGCAAATCATGAAGACAAAGAATGG
AAGTTTGCTCGAGCAAAATTATGGCTTAGCTACTTTGATGACAAATGTACGTTACCTCCA
CCTTTCAACATCATTCCCTCACCAAAGACTATCTGCTATATGATTAGTAGCCTCAGTAAG
TGGATTTGCTCTCATACATCAAAAGGCAAGGTCAAACGGCAAAACAGTTTAAAGGAATGG
AGGAATTTGAAACAGAAGAGAGATGAAAACTATCAAAAAGTGATGTGCTGCCTAGTGCAT
CGTTACTTGACTTCCATGAGACAGAAGATGCAAAGTACAGATCAGGCAACTGTGGAAAAT
CTAAACGAACTGCGCCAAGATCTGTCAAAATTCCGAAATGAAATAAGGGATTTACTTGGC
TTTCGGACTTCTAAATATGCTATGTTTTATCCAAGAAATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 793 |
| Molecular Weight
| 91211.0 |
| Theoretical pI
| 8.13 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["387-407", "416-436", "458-475", "540-560", "587-607", "617-637"]
|
| Protein Sequence
|
>Short transient receptor potential channel 1
MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDY
YMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDS
EVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLK
QDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFEL
SADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGL
LEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIF
WPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPAL
ERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKF
HDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKF
LGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFS
LAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEW
KFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEW
RNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLG
FRTSKYAMFYPRN
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P48995 |
| UniProtKB/Swiss-Prot Entry Name
| TRPC1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U31110 |
| GeneCard ID
| TRPC1 |
| GenAtlas ID
| TRPC1 |
| HGNC ID
| HGNC:12333 |
| References |
|---|
| General References
| Not Available |