| Identification |
|---|
| HMDB Protein ID
| CDBP03287 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thyrotropin-releasing hormone receptor |
| Description
| Not Available |
| Synonyms
|
- TRH-R
- Thyroliberin receptor
|
| Gene Name
| TRHR |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| receptor activity |
| transmembrane receptor activity |
| thyrotropin-releasing hormone receptor activity |
| molecular transducer activity |
| signal transducer activity |
| g-protein coupled receptor activity |
| Process |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
| signaling |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q23 |
| SNPs
| TRHR |
| Gene Sequence
|
>1197 bp
ATGGAAAACGAGACAGTCAGTGAACTGAACCAAACACAGCTTCAGCCACGAGCAGTGGTG
GCCTTAGAATACCAGGTGGTCACCATCTTACTTGTACTCATTATTTGTGGCCTGGGCATT
GTAGGCAACATCATGGTAGTCCTGGTTGTCATGAGAACCAAGCACATGAGGACCCCCACA
AACTGCTACCTGGTGAGCCTGGCAGTAGCTGATCTCATGGTCTTGGTGGCCGCAGGCCTC
CCCAACATAACAGACAGTATCTACGGTTCCTGGGTCTATGGCTATGTTGGATGCCTCTGC
ATTACTTACCTCCAGTATTTGGGAATTAATGCATCCTCTTGTTCAATAACAGCCTTTACC
ATTGAGAGGTACATAGCAATCTGTCACCCCATCAAAGCCCAGTTTCTCTGCACATTTTCC
AGAGCCAAAAAGATTATCATCTTTGTCTGGGCTTTCACATCTCTTTACTGTATGCTCTGG
TTCTTCTTGCTGGATCTCAATATTAGCACCTACAAAGATGCTATTGTGATATCCTGTGGC
TACAAGATCTCCAGGAATTACTACTCACCTATTTACCTAATGGACTTTGGTGTCTTTTAT
GTTGTGCCAATGATCCTGGCTACCGTCCTCTATGGATTCATAGCTAGAATCCTTTTCTTA
AATCCCATTCCTTCAGATCCTAAAGAAAACTCTAAGACATGGAAAAATGATTCAACCCAT
CAGAACACAAATCTGAATGTAAATACCTCTAATAGATGTTTCAACAGCACAGTATCTTCA
AGGAAGCAGGTCACCAAGATGCTGGCAGTGGTTGTAATTCTGTTTGCCCTTTTATGGATG
CCCTACAGGACTCTAGTGGTTGTCAACTCATTTCTCTCCAGTCCTTTCCAAGAAAATTGG
TTTTTGCTCTTTTGCAGAATTTGCATTTATCTCAACAGTGCCATCAACCCGGTGATTTAC
AATCTCATGTCCCAGAAATTCCGTGCAGCCTTCAGAAAGCTCTGCAACTGCAAGCAGAAG
CCAACAGAGAAACCTGCTAACTACAGTGTGGCCCTAAATTACAGCGTCATCAAGGAGTCA
GACCATTTCAGCACAGAGCTTGATGATATCACTGTCACTGACACTTACCTGTCTGCCACA
AAAGTGTCTTTTGATGACACCTGCTTGGCTTCTGAGGTATCCTTTAGCCAAAGTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 398 |
| Molecular Weight
| 45084.4 |
| Theoretical pI
| 8.35 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["29-51", "62-83", "100-121", "145-168", "194-215", "267-288", "297-319"]
|
| Protein Sequence
|
>Thyrotropin-releasing hormone receptor
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
|
| External Links |
|---|
| GenBank ID Protein
| 4507681 |
| UniProtKB/Swiss-Prot ID
| P34981 |
| UniProtKB/Swiss-Prot Entry Name
| TRFR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_003301.4 |
| GeneCard ID
| TRHR |
| GenAtlas ID
| TRHR |
| HGNC ID
| HGNC:12299 |
| References |
|---|
| General References
| Not Available |