| Identification |
|---|
| HMDB Protein ID
| CDBP03286 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tropomyosin alpha-3 chain |
| Description
| Not Available |
| Synonyms
|
- Gamma-tropomyosin
- Tropomyosin-3
- Tropomyosin-5
- hTM5
|
| Gene Name
| TPM3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21.2 |
| SNPs
| TPM3 |
| Gene Sequence
|
>855 bp
ATGGAGGCCATCAAGAAAAAGATGCAGATGCTGAAGTTAGACAAGGAGAATGCTCTGGAT
CGGGCAGAGCAAGCTGAAGCTGAGCAGAAGCAGGCAGAAGAAAGAAGTAAACAGCTGGAG
GATGAGCTGGCAGCCATGCAGAAGAAGCTGAAAGGGACAGAGGATGAGCTGGACAAGTAT
TCTGAAGCTTTGAAGGATGCCCAGGAGAAGCTGGAACTGGCAGAGAAGAAGGCTGCTGAT
GCTGAGGCTGAGGTGGCCTCCTTGAACCGTAGGATCCAGCTGGTTGAAGAAGAGCTGGAC
CGTGCTCAGGAGCGCCTGGCCACTGCCCTGCAAAAGCTGGAAGAAGCTGAAAAAGCTGCT
GATGAGAGTGAGAGAGGTATGAAGGTTATTGAAAACCGGGCCTTAAAAGATGAAGAAAAG
ATGGAACTCCAGGAAATCCAACTCAAAGAAGCTAAGCACATTGCAGAAGAGGCAGATAGG
AAGTATGAAGAGGTGGCTCGTAAGTTGGTGATCATTGAAGGAGACTTGGAACGCACAGAG
GAACGAGCTGAGCTGGCAGAGTCTAAGTGTTCTGAGCTGGAGGAGGAGCTGAAGAATGTC
ACCAACAACCTCAAGTCTCTTGAGGCTCAGGCGGAGAAGTACTCTCAAAAAGAAGATAAA
TATGAGGAAGAAATCAAGATTCTTACTGATAAACTCAAGGAGGCAGAGACCCGTGCTGAG
TTTGCTGAGAGATCGGTAGCCAAGCTGGAAAAGACAATTGATGACCTGGAAGATGAGCTC
TATGCCCAGAAACTGAAGTACAAGGCCATTAGCGAGGAGCTGGACCACGCCCTCAATGAC
ATGACCTCTATATAA
|
| Protein Properties |
|---|
| Number of Residues
| 284 |
| Molecular Weight
| 32818.4 |
| Theoretical pI
| 4.38 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tropomyosin alpha-3 chain
MEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKY
SEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA
DESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTE
ERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAE
FAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
|
| External Links |
|---|
| GenBank ID Protein
| 55665784 |
| UniProtKB/Swiss-Prot ID
| P06753 |
| UniProtKB/Swiss-Prot Entry Name
| TPM3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AL590431 |
| GeneCard ID
| TPM3 |
| GenAtlas ID
| TPM3 |
| HGNC ID
| HGNC:12012 |
| References |
|---|
| General References
| Not Available |