Showing Protein Two pore calcium channel protein 2 (CDBP03283)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03283
Secondary Accession Numbers Not Available
Name Two pore calcium channel protein 2
Description Not Available
Synonyms
  1. Voltage-dependent calcium channel protein TPC2
Gene Name TPCN2
Protein Type Transporter
Biological Properties
General Function Involved in ion channel activity
Specific Function May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane
GO Classification
Component
membrane
cell part
Function
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
transmembrane transporter activity
Process
establishment of localization
transport
transmembrane transport
ion transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11q13.3
SNPs TPCN2
Gene Sequence 
>2259 bp
ATGGCGGAACCCCAGGCGGAGTCGGAGCCCCTGCTGGGCGGGGCCCGCGGCGGTGGCGGC
GACTGGCCGGCGGGGCTGACCACTTACCGCAGCATCCAAGTCGGCCCTGGTGCCGCGGCC
AGGTGGGACCTCTGCATTGATCAGGCTGTGGTCTTCATCGAAGATGCTATTCAGTACCGC
TCCATCAACCACCGGGTGGATGCCAGCTCGATGTGGCTTTACCGACGGTATTACTCGAAC
GTATGCCAACGGACTTTGAGCTTCACCATCTTCTTGATCCTGTTTTTGGCTTTTATCGAG
ACCCCATCCTCACTCACCAGCACGGCGGACGTGCGCTACCGCGCTGCCCCCTGGGAGCCG
CCCTGCGGCCTGACCGAGAGTGTCGAGGTGCTCTGCCTGCTGGTCTTTGCGGCCGACCTC
TCTGTGAAGGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGGCTGCTGGGC
TACCTCGTGGTGCTGGTGGTGTCTCTGGTGGACTGGACCGTGTCCCTGAGTCTCGTGTGT
CATGAGCCCCTGCGGATCCGCCGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTCCTCT
ATGATGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCCAGCGTCGGG
CTGCTGCTGGCCATCCACCTGTGCCTCTTCACCATGTTCGGAATGCTGCTGTTCGCTGGT
GGGAAGCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAG
TCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCT
GCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGC
CTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATG
AAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTC
CTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAG
AACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATG
GAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTC
AACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCG
TTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTC
ATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTG
CCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTAC
CTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCC
AGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTG
GCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATGGTGGGCCTGCTGTCGCTG
TGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCC
AGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGT
GCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCCATCATTGGGATCAACTTG
TTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCG
GCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCG
GCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAACTGGCAGGTGTTTCTGGAT
GCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTG
TCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAG
TGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATG
ACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAG
AGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGA
Protein Properties
Number of Residues 752
Molecular Weight 85242.1
Theoretical pI 7.1
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["85-105", "156-176", "219-239", "290-310", "337-357", "440-460", "466-486", "503-523", "555-575", "581-601", "639-659", "674-694"]
Protein Sequence 
>Two pore calcium channel protein 2
MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR
SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP
PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC
HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG
GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS
LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ
NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP
FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY
LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL
WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL
FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD
AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM
TVELLFRDILEEPGEDELTERLSQHPHLWLCR
GenBank ID Protein 157502181
UniProtKB/Swiss-Prot ID Q8NHX9
UniProtKB/Swiss-Prot Entry Name TPC2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_139075.3
GeneCard ID TPCN2
GenAtlas ID TPCN2
HGNC ID HGNC:20820
References
General References Not Available