| Identification |
|---|
| HMDB Protein ID
| CDBP03251 |
| Secondary Accession Numbers
| Not Available |
| Name
| Gamma-synuclein |
| Description
| Not Available |
| Synonyms
|
- Breast cancer-specific gene 1 protein
- Persyn
- SR
- Synoretin
|
| Gene Name
| SNCG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway |
| GO Classification
|
| Component |
| cell part |
| intracellular part |
| cytoplasm |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm
- Cytoplasm
- perinuclear region
- cytoskeleton
- cytoskeleton
- spindle
- centrosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q23.2-q23.3 |
| SNPs
| SNCG |
| Gene Sequence
|
>384 bp
ATGGATGTTTTCAAGAAGGGCTTCTCCATCGCCAAGAAGGGCGTGGTGGGTGCGGTGGAA
AAGACCAAGCAGGGGGTGACGGAAGCAGCTGAGAAGACCAAGGAGGGGGTCATGTATGTG
GGAGCCAAGACCAAGGAGAATGTTGTACAGAGCGTGACCTCAGTGGCCGAGAAGACCAAG
GAGCAGGCCAACGCCGTGAGCAAGGCTGTGGTGAGCAGCGTCAACACTGTGGCCACCAAG
ACCGTGGAGGAGGCGGAGAACATCGCGGTCACCTCCGGGGTGGTGCGCAAGGAGGACTTG
AGGCCATCTGCCCCCCAACAGGAGGGTGAGGCATCCAAAGAGAAAGAGGAAGTGGCAGAG
GAGGCCCAGAGTGGGGGAGACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 127 |
| Molecular Weight
| 13330.8 |
| Theoretical pI
| 4.54 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Gamma-synuclein
MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK
EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE
EAQSGGD
|
| External Links |
|---|
| GenBank ID Protein
| 2281474 |
| UniProtKB/Swiss-Prot ID
| O76070 |
| UniProtKB/Swiss-Prot Entry Name
| SYUG_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF010126 |
| GeneCard ID
| SNCG |
| GenAtlas ID
| SNCG |
| HGNC ID
| HGNC:11141 |
| References |
|---|
| General References
| Not Available |