| Identification |
|---|
| HMDB Protein ID
| CDBP03247 |
| Secondary Accession Numbers
| Not Available |
| Name
| Synaptotagmin-6 |
| Description
| Not Available |
| Synonyms
|
- Synaptotagmin VI
- SytVI
|
| Gene Name
| SYT6 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis |
| GO Classification
|
| Component |
| cytoplasmic vesicle |
| cytoplasmic membrane-bounded vesicle |
| coated vesicle |
| clathrin-coated vesicle |
| synaptic vesicle |
| membrane |
| cell part |
| organelle |
| vesicle |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Cytoplasmic vesicle
- Single-pass membrane protein
- secretory vesicle
- synaptic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p13.2 |
| SNPs
| SYT6 |
| Gene Sequence
|
>2840 bp
ATGAGCGGAGTGTGGGGGGCCGGCGGGCCTCGGTGCCAGGAGGCGCTCGCGGTCCTCGCC
TCGCTGTGCCGGGCCCGGCCGCCCCCTCTCGGGCTGGACGTGGAGACTTGTCGGAGCTTC
GAGCTGCAGCCCCCAGAGCGGAGTCCCAGCGCGGCAGGCGCAGGCACCTCTGTCAGCCTC
CTCGCAGTTGTAGTTATTGTGTGTGGCGTGGCCCTGGTGGCAGTTTTTCTCTTTCTCTTT
TGGAAGCTGTGCTGGATGCCCTGGAGGAACAAGGAGGCCTCCAGTCCCTCTTCTGCTAAT
CCCCCCTTGGAAGCCCTCCAGAGCCCCAGCTTCAGAGGCAACATGGCGGACAAGCTGAAG
GACCCCAGCACCCTGGGCTTCCTGGAGGCGGCCGTGAAGATCAGCCACACGTCCCCAGAT
ATCCCAGCTGAGGTGCAGATGTCGGTCAAGGAGCACATCATGCGTCACACCCGGCTGCAG
CGGCAAACTACAGAGCCAGCGTCATCCACCAGGCACACGTCCTTCAAGCGCCACCTGCCA
AGGCAGATGCATGTCTCCAGTGTAGACTATGGCAATGAGCTTCCACCAGCAGCAGAGCAG
CCCACCAGCATTGGCCGCATCAAGCCTGAGCTCTACAAGCAGAAGTCGGTGGATGGGGAG
GATGCCAAGTCTGAGGCCACCAAGAGCTGCGGGAAGATCAACTTCAGCCTACGCTACGAT
TACGAGACCGAGACCCTGATTGTGCGTATCCTGAAGGCTTTTGACCTCCCTGCCAAGGAC
TTTTGTGGAAGCTCTGACCCTTATGTCAAGATCTACCTCCTGCCTGACCGCAAATGCAAG
CTGCAGACCCGGGTGCACCGCAAGACCCTGAACCCCACCTTTGATGAGAACTTCCACTTC
CCTGTGCCCTATGAGGAGCTGGCTGACCGCAAGCTGCATCTCAGTGTCTTCGACTTTGAC
CGCTTCTCCCGCCATGACATGATTGGCGAGGTCATCCTGGACAACCTCTTTGAGGCCTCT
GACCTGTCTCGGGAAACCTCCATCTGGAAGGATATCCAATATGCCACAAGTGAAAGCGTG
GACTTGGGAGAGATCATGTTCTCCCTTTGCTACCTGCCCACTGCAGGCAGGCTCACCCTC
ACAGTGATTAAGTGTCGGAACCTCAAGGCGATGGACATCACAGGCTATTCAGATCCCTAT
GTGAAAGTGTCCTTGCTCTGTGATGGGCGGAGGCTGAAGAAGAAGAAAACAACCATAAAG
AAAAACACTCTCAATCCTGTCTACAATGAGGCCATCATCTTTGACATTCCCCCGGAAAAC
ATGGATCAAGTCAGCCTGCTCATCTCAGTCATGGACTATGATCGAGTGGGCCACAATGAG
ATCATAGGAGTCTGTCGTGTGGGGATCACTGCTGAAGGCCTGGGCAGGGACCACTGGAAC
GAGATGCTGGCATACCCCCGGAAGCCCATCGCACACTGGCACTCCTTGGTGGAGGTAAAG
AAATCCTTCAAAGAGGGAAACCCTCGGTTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 510 |
| Molecular Weight
| 57324.4 |
| Theoretical pI
| 8.29 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Synaptotagmin-6
MSGVWGAGGPRCQEALAVLASLCRARPPPLGLDVETCRSFELQPPERSPSAAGAGTSVSL
LAVVVIVCGVALVAVFLFLFWKLCWMPWRNKEASSPSSANPPLEALQSPSFRGNMADKLK
DPSTLGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTRLQRQTTEPASSTRHTSFKRHLP
RQMHVSSVDYGNELPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYD
YETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHF
PVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSESV
DLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIK
KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWN
EMLAYPRKPIAHWHSLVEVKKSFKEGNPRL
|
| External Links |
|---|
| GenBank ID Protein
| 123273719 |
| UniProtKB/Swiss-Prot ID
| Q5T7P8 |
| UniProtKB/Swiss-Prot Entry Name
| SYT6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL162594 |
| GeneCard ID
| SYT6 |
| GenAtlas ID
| SYT6 |
| HGNC ID
| HGNC:18638 |
| References |
|---|
| General References
| Not Available |