| Identification |
|---|
| HMDB Protein ID
| CDBP03246 |
| Secondary Accession Numbers
| Not Available |
| Name
| Synaptotagmin-5 |
| Description
| Not Available |
| Synonyms
|
- Synaptotagmin V
- SytV
|
| Gene Name
| SYT5 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface |
| GO Classification
|
| Component |
| coated vesicle |
| clathrin-coated vesicle |
| synaptic vesicle |
| membrane |
| cell part |
| organelle |
| vesicle |
| cytoplasmic vesicle |
| cytoplasmic membrane-bounded vesicle |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Cytoplasmic vesicle
- Single-pass membrane protein
- Single-pass membrane protein
- secretory vesicle
- synaptic vesicle membrane
- Recycling endosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q|11p |
| SNPs
| SYT5 |
| Gene Sequence
|
>1161 bp
ATGTTCCCGGAGCCCCCAACCCCGGGGCCTCCATCGCCCGACACGCCTCCCGACTCCAGT
CGCATCAGCCACGGCCCAGTGCCCCCCTGGGCCCTGGCCACCATCGTGCTGGTCTCAGGC
CTCCTCATCTTCAGCTGCTGTTTCTGTCTCTACCGGAAGAGCTGTCGGAGGCGGACAGGC
AAGAAGAGCCAGGCCCAAGCCCAGGTCCACCTTCAGGAAGTGAAGGGGCTGGGCCAGAGT
TACATAGACAAGGTGCAGCCAGAAGTAGAGGAGCTGGAGCCAGCACCATCCGGGCCAGGG
CAGCAGGTGGCAGACAAGCATGAGCTAGGACAACTGCAGTACTCCCTGGATTATGACTTC
CAGAGTGGCCAGCTGCTGGTGGGCATTCTGCAAGCAATGGGATTGGCAGCCTTGGATCTT
GGTGGCTCCTCGGACCCCTATGTGCGGGTCTACCTGCTGCCGGACAAACGGAGGCGGTAC
GAGACCAAGGTGCATCGGCAGACGCTGAACCCTCACTTTGGGGAGACCTTCGCCTTCAAG
GTCCCCTACGTGGAGCTGGGGGGCAGGGTGCTGGTCATGGCGGTGTACGACTTCGACCGC
TTCTCTCGCAATGACGCCATCGGGGAGGTGCGGGTCCCTATGAGCTCCGTGGACCTGGGG
CGGCCAGTGCAGGCCTGGCGGGAGCTGCAGGCGGCTCCGCGGGAGGAGCAGGAGAAGCTT
GGGGACATCTGCTTCTCCCTCCGCTATGTCCCCACGGCCGGGAAGCTCACCGTCATCGTC
CTGGAGGCTAAAAACCTGAAGAAGATGGACGTAGGAGGACTGTCAGATCCATACGTCAAG
GTCCACCTGCTGCAGGGCGGCAAAAAGGTGCGGAAGAAGAAAACCACCATCAAGAAGAAC
ACTCTGAACCCCTATTACAACGAAGCTTTCAGCTTCGAGGTGCCCTGTGACCAAGTCCAG
AAGGTGCAGGTGGAGCTGACCGTGCTGGACTACGACAAGCTGGGCAAGAACGAGGCCATC
GGGAGGGTGGCCGTGGGGGCGGCCGCCGGCGGGGCTGGCCTGCGGCACTGGGCGGACATG
CTGGCCAACCCGCGGCGGCCCATTGCCCAGTGGCACTCGCTGCGGCCCCCGGACCGAGTG
AGGCTGCTGCCTGCGCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 386 |
| Molecular Weight
| 42900.2 |
| Theoretical pI
| 9.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Synaptotagmin-5
MFPEPPTPGPPSPDTPPDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTG
KKSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDF
QSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFK
VPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKL
GDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKN
TLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADM
LANPRRPIAQWHSLRPPDRVRLLPAP
|
| External Links |
|---|
| GenBank ID Protein
| 28279301 |
| UniProtKB/Swiss-Prot ID
| O00445 |
| UniProtKB/Swiss-Prot Entry Name
| SYT5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC046157 |
| GeneCard ID
| SYT5 |
| GenAtlas ID
| SYT5 |
| HGNC ID
| HGNC:11513 |
| References |
|---|
| General References
| Not Available |