| Identification |
|---|
| HMDB Protein ID
| CDBP03245 |
| Secondary Accession Numbers
| Not Available |
| Name
| Synaptotagmin-4 |
| Description
| Not Available |
| Synonyms
|
- Synaptotagmin IV
- SytIV
|
| Gene Name
| SYT4 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis |
| GO Classification
|
| Component |
| clathrin-coated vesicle |
| synaptic vesicle |
| membrane |
| cell part |
| organelle |
| vesicle |
| cytoplasmic vesicle |
| cytoplasmic membrane-bounded vesicle |
| coated vesicle |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Cytoplasmic vesicle
- Single-pass membrane protein
- secretory vesicle
- synaptic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q12.3 |
| SNPs
| SYT4 |
| Gene Sequence
|
>1278 bp
ATGGCTCCGATCACCACCAGCCGGGAAGAATTTGATGAAATCCCCACAGTGGTGGGGATC
TTCAGTGCATTTGGCCTGGTCTTCACAGTCTCTCTCTTTGCATGGATCTGCTGTCAGAGA
AAATCATCCAAGTCTAACAAGACTCCTCCATACAAGTTTGTGCATGTGCTTAAGGGAGTT
GATATTTACCCTGAAAACCTAAATAGCAAAAAGAAGTTTGGAGCAGATGATAAAAATGAA
GTAAAGAATAAGCCAGCTGTGCCAAAGAATTCATTGCATCTGGATCTTGAAAAGAGAGAT
CTCAATGGCAATTTTCCCAAAACCAACCTCAAACCTGGCAGTCCTTCTGATCTGGAGAAT
GCAACCCCGAAGCTCTTTTTAGAAGGGGAAAAAGAGTCAGTTTCCCCTGAGAGTTTAAAG
TCCAGCACTTCCCTTACTTCAGAAGAGAAACAAGAGAAGCTGGGAACTCTCTTCTTCTCC
TTAGAATACAACTTCGAGAGAAAAGCATTTGTGGTCAATATCAAGGAAGCCCGTGGCTTG
CCAGCCATGGATGAGCAGTCGATGACCTCTGACCCATATATCAAAATGACGATCCTCCCA
GAGAAGAAGCATAAAGTGAAAACTAGAGTGCTGAGAAAAACCTTGGATCCAGCTTTTGAT
GAGACCTTTACATTCTATGGGATACCCTACACCCAAATCCAAGAATTGGCCTTGCACTTC
ACAATTTTGAGTTTTGACAGGTTTTCAAGAGATGATATCATTGGGGAAGTTCTAATTCCT
CTCTCGGGAATTGAATTATCTGAAGGAAAAATGTTAATGAATAGAGAGATCATCAAGAGA
AATGTTAGGAAGTCTTCAGGACGGGGTGAGTTACTGATCTCTCTCTGCTATCAGTCCACC
ACAAACACTCTAACTGTGGTTGTCTTAAAAGCTCGACATCTGCCTAAATCTGATGTGTCC
GGACTTTCAGATCCCTATGTCAAAGTGAACCTGTACCATGCCAAAAAGAGAATCTCCAAG
AAGAAGACTCATGTGAAGAAATGCACCCCCAATGCAGTGTTCAATGAGCTGTTTGTCTTT
GATATTCCTTGTGAGGGCCTTGAAGATATAAGTGTTGAATTTTTGGTTTTGGATTCTGAA
AGGGGGTCCCGAAATGAGGTAATCGGGCAGTTAGTCTTGGGTGCAGCAGCAGAAGGAACT
GGTGGAGAGCACTGGAAAGAGATCTGTGACTACCCCAGGAGACAAATTGCCAAGTGGCAC
GTGCTCTGTGATGGTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 425 |
| Molecular Weight
| 47957.8 |
| Theoretical pI
| 8.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Synaptotagmin-4
MAPITTSREEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRKSSKSNKTPPYKFVHVLKGV
DIYPENLNSKKKFGADDKNEVKNKPAVPKNSLHLDLEKRDLNGNFPKTNLKPGSPSDLEN
ATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGL
PAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHF
TILSFDRFSRDDIIGEVLIPLSGIELSEGKMLMNREIIKRNVRKSSGRGELLISLCYQST
TNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVF
DIPCEGLEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGGEHWKEICDYPRRQIAKWH
VLCDG
|
| External Links |
|---|
| GenBank ID Protein
| 24308219 |
| UniProtKB/Swiss-Prot ID
| Q9H2B2 |
| UniProtKB/Swiss-Prot Entry Name
| SYT4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_020783.3 |
| GeneCard ID
| SYT4 |
| GenAtlas ID
| SYT4 |
| HGNC ID
| HGNC:11512 |
| References |
|---|
| General References
| Not Available |