| Identification |
|---|
| HMDB Protein ID
| CDBP03238 |
| Secondary Accession Numbers
| Not Available |
| Name
| Synaptophysin |
| Description
| Not Available |
| Synonyms
|
- Major synaptic vesicle protein p38
|
| Gene Name
| SYP |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity |
| GO Classification
|
| Component |
| coated vesicle |
| clathrin-coated vesicle |
| synaptic vesicle |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| organelle |
| integral to membrane |
| vesicle |
| cytoplasmic vesicle |
| cytoplasmic membrane-bounded vesicle |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Cytoplasmic vesicle
- Multi-pass membrane protein
- secretory vesicle
- Cell junction
- synapse
- synaptosome
- synaptic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| SYP |
| Gene Sequence
|
>942 bp
ATGCTGCTGCTGGCGGACATGGACGTGGTGAATCAGCTGGTGGCTGGGGGTCAGTTCCGG
GTGGTCAAGGAGCCCCTCGGCTTTGTGAAGGTGCTGCAATGGGTCTTCGCCATCTTCGCC
TTTGCCACATGCGGCAGCTACAGTGGGGAGCTCCAGCTGAGCGTGGATTGTGCCAACAAG
ACCGAGAGTGACCTCAGCATCGAGGTCGAGTTCGAGTACCCCTTCAGGCTGCACCAAGTG
TACTTTGATGCACCCACCTGCCGAGGGGGCACCACCAAGGTCTTCTTAGTTGGGGACTAC
TCCTCGTCAGCCGAATTCTTTGTCACCGTGGCCGTGTTTGCCTTCCTCTACTCCATGGGG
GCTCTGGCCACCTACATCTTCCTGCAGAACAAGTACCGAGAGAATAACAAAGGGCCCATG
CTGGACTTTCTGGCCACGGCTGTGTTCGCCTTCATGTGGCTAGTTAGCTCATCGGCATGG
GCCAAGGGGCTGTCAGATGTGAAGATGGCCACAGACCCAGAGAACATTATCAAGGAGATG
CCTGTCTGCCGCCAGACAGGGAACACATGCAAGGAGCTGAGAGACCCTGTGACCTCGGGA
CTCAACACCTCGGTGGTGTTCGGCTTCCTGAACCTGGTGCTCTGGGTCGGCAACCTGTGG
TTCGTGTTTAAGGAGACAGGCTGGGCCGCCCCGTTCCTGCGCGCGCCTCCCGGCGCCCCC
GAGAAACAACCGGCACCCGGGGACGCCTACGGCGATGCAGGCTACGGGCAGGGCCCCGGC
GGGTACGGGCCCCAGGATTCCTACGGGCCTCAGGGCGGCTACCAGCCTGACTATGGTCAA
CCAGCCGGCAGCGGTGGCAGTGGCTACGGGCCTCAGGGCGACTATGGGCAGCAAGGCTAC
GGCCCGCAGGGTGCACCCACCTCCTTCTCCAATCAGATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 313 |
| Molecular Weight
| 33845.1 |
| Theoretical pI
| 4.41 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["26-49", "107-130", "138-161", "200-223"]
|
| Protein Sequence
|
>Synaptophysin
MLLLADMDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANK
TESDLSIEVEFEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMG
ALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEM
PVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAP
EKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPAGSGGSGYGPQGDYGQQGY
GPQGAPTSFSNQM
|
| External Links |
|---|
| GenBank ID Protein
| 189053611 |
| UniProtKB/Swiss-Prot ID
| P08247 |
| UniProtKB/Swiss-Prot Entry Name
| SYPH_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK313030 |
| GeneCard ID
| SYP |
| GenAtlas ID
| SYP |
| HGNC ID
| HGNC:11506 |
| References |
|---|
| General References
| Not Available |