| Identification |
|---|
| HMDB Protein ID
| CDBP03236 |
| Secondary Accession Numbers
| Not Available |
| Name
| Synaptic vesicle glycoprotein 2C |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SV2C |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane transport |
| Specific Function
| Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Cytoplasmic vesicle
- Multi-pass membrane protein
- secretory vesicle
- synaptic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q13.3 |
| SNPs
| SV2C |
| Gene Sequence
|
>2184 bp
ATGGAAGACTCTTACAAGGATAGGACTTCACTGATGAAGGGTGCCAAGGACATTGCCAGA
GAGGTGAAGAAACAAACAGTAAAGAAGGTGAATCAAGCTGTGGACCGAGCCCAGGATGAA
TACACCCAGAGGTCCTACAGTCGGTTCCAAGATGAAGAAGATGATGATGACTACTACCCG
GCTGGAGAAACCTATAATGGTGAGGCCAACGATGACGAAGGCTCAAGTGAAGCCACTGAG
GGGCATGATGAAGATGATGAGATCTATGAGGGGGAGTATCAGGGCATCCCCAGTATGAAC
CAAGCGAAGGACAGCATCGTGTCAGTGGGGCAGCCCAAGGGCGATGAGTACAAGGACCGA
CGGGAGCTGGAATCAGAAAGGAGAGCTGACGAGGAAGAGTTAGCCCAGCAGTATGAGCTG
ATAATCCAAGAATGCGGTCATGGTCGTTTTCAGTGGGCCCTTTTCTTCGTCCTGGGCATG
GCTCTTATGGCAGACGGTGTAGAGGTGTTTGTCGTTGGCTTCGTGTTACCCAGTGCTGAG
ACAGACCTCTGCATCCCAAATTCAGGATCTGGATGGCTAGGCAGCATAGTGTACCTCGGG
ATGATGGTGGGGGCGTTCTTCTGGGGAGGACTGGCAGACAAAGTGGGAAGGAAACAGTCT
CTTCTGATTTGCATGTCTGTCAACGGATTCTTTGCCTTCCTTTCTTCATTTGTCCAAGGT
TATGGCTTCTTTCTCTTCTGTCGCTTACTTTCTGGATTCGGGATTGGAGGAGCCATACCC
ACTGTGTTCTCGTACTTTGCTGAAGTCCTGGCCCGGGAAAAGCGGGGCGAACACTTGAGC
TGGCTCTGCATGTTCTGGATGATCGGTGGCATCTACGCCTCTGCCATGGCCTGGGCCATC
ATCCCGCACTACGGGTGGAGCTTCAGCATGGGATCGGCCTACCAGTTTCACAGTTGGCGT
GTGTTTGTCATCGTCTGTGCACTCCCCTGTGTCTCCTCCGTGGTGGCCCTCACATTCATG
CCTGAAAGCCCACGATTCTTGTTGGAGGTTGGAAAACATGATGAAGCTTGGATGATTCTG
AAGTTAATTCATGACACCAACATGAGAGCCCGGGGTCAGCCTGAGAAGGTCTTCACGGTA
AACAAAATAAAAACTCCTAAACAAATAGATGAGCTGATTGAAATTGAGAGTGACACAGGA
ACATGGTATAGGAGGTGTTTTGTTCGGATCCGCACCGAGCTGTACGGAATTTGGTTGACT
TTTATGAGATGTTTCAACTACCCAGTCAGGGATAATACAATAAAGCTTACAATTGTTTGG
TTCACCCTGTCCTTTGGGTACTATGGATTATCCGTTTGGTTCCCTGATGTCATTAAACCT
CTGCAGTCCGATGAATATGCATTGCTAACCAGAAATGTGGAGAGAGATAAATATGCAAAT
TTCACTATTAACTTTACAATGGAAAATCAGATTCATACTGGAATGGAATACGACAATGGC
AGATTCATAGGGGTCAAGTTCAAATCTGTAACTTTCAAAGACTCTGTTTTTAAGTCCTGC
ACCTTTGAGGATGTAACTTCAGTGAACACCTACTTCAAGAACTGCACATTTATTGACACT
GTTTTTGACAACACAGATTTTGAGCCATATAAATTCATTGACAGTGAATTTAAAAACTGC
TCGTTTTTTCACAACAAGACGGGATGTCAGATTACCTTTGATGATGACTATAGTGCCTAC
TGGATTTATTTTGTCAACTTTCTGGGGACATTGGCAGTATTGCCAGGGAACATTGTGTCT
GCTCTGCTGATGGACAGAATTGGGCGCTTAACAATGCTAGGTGGCTCTATGGTGCTTTCG
GGGATCAGCTGTTTCTTCCTTTGGTTCGGCACCAGTGAATCCATGATGATAGGCATGCTG
TGTCTGTACAATGGATTGACCATCTCAGCCTGGAACTCTCTTGACGTGGTCACTGTGGAA
CTGTACCCCACAGACCGGAGGGCAACAGGCTTTGGCTTCTTAAATGCGCTATGCAAGGCA
GCAGCCGTCCTGGGAAACTTAATATTTGGCTCTCTGGTCAGCATCACCAAATCAATCCCC
ATCCTGCTGGCTTCTACTGTGCTCGTGTGTGGAGGACTCGTTGGGCTGTGCCTGCCTGAC
ACACGAACCCAGGTTCTGATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 727 |
| Molecular Weight
| 82341.5 |
| Theoretical pI
| 4.67 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["155-175", "192-212", "227-247", "249-269", "281-301", "321-341", "438-458", "579-599", "610-630", "637-657", "670-690", "699-719"]
|
| Protein Sequence
|
>Synaptic vesicle glycoprotein 2C
MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYP
AGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDR
RELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE
TDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQG
YGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAI
IPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMIL
KLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLT
FMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYAN
FTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDT
VFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVS
ALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVE
LYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPD
TRTQVLM
|
| External Links |
|---|
| GenBank ID Protein
| 73695465 |
| UniProtKB/Swiss-Prot ID
| Q496J9 |
| UniProtKB/Swiss-Prot Entry Name
| SV2C_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014979.1 |
| GeneCard ID
| SV2C |
| GenAtlas ID
| SV2C |
| HGNC ID
| HGNC:30670 |
| References |
|---|
| General References
| Not Available |