| Identification |
|---|
| HMDB Protein ID
| CDBP03234 |
| Secondary Accession Numbers
| Not Available |
| Name
| Synaptic vesicle glycoprotein 2A |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SV2A |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane transport |
| Specific Function
| Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Cytoplasmic vesicle
- Multi-pass membrane protein
- secretory vesicle
- synaptic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21.2 |
| SNPs
| SV2A |
| Gene Sequence
|
>2229 bp
ATGGAAGAGGGCTTCCGAGACCGGGCAGCTTTCATCCGTGGGGCCAAAGACATTGCTAAG
GAAGTCAAAAAGCATGCGGCCAAGAAGGTGGTGAAGGGCCTGGACAGAGTCCAGGACGAA
TATTCCCGAAGATCGTACTCCCGCTTTGAGGAGGAGGATGATGATGATGACTTCCCTGCT
CCCAGTGATGGTTATTACCGAGGAGAAGGGACCCAGGATGAGGAGGAAGGTGGTGCATCC
AGTGATGCTACTGAGGGCCATGACGAGGATGATGAGATCTATGAAGGGGAATATCAGGGC
ATTCCCCGGGCAGAGTCTGGGGGCAAAGGCGAGCGGATGGCAGATGGGGCGCCCCTGGCT
GGAGTAAGGGGGGGCTTGAGTGATGGGGAGGGTCCCCCTGGGGGCCGGGGGGAGGCACAA
CGACGGAAAGAACGAGAAGAACTGGCCCAACAGTATGAAGCCATCCTACGGGAGTGTGGC
CACGGCCGCTTCCAGTGGACACTGTATTTTGTGCTTGGTCTGGCGCTGATGGCTGACGGT
GTGGAGGTCTTTGTGGTGGGCTTCGTGCTGCCCAGCGCTGAGAAAGACATGTGCCTGTCC
GACTCCAACAAAGGCATGCTAGGCCTCATCGTCTACCTGGGCATGATGGTGGGAGCCTTC
CTCTGGGGAGGTCTGGCTGACCGGCTGGGTCGGAGGCAGTGTCTGCTCATCTCGCTCTCA
GTCAACAGCGTCTTCGCCTTCTTCTCATCTTTTGTCCAGGGTTACGGCACTTTCCTCTTC
TGCCGCCTACTTTCTGGGGTTGGGATTGGAGGGTCCATCCCCATTGTCTTCTCCTATTTC
TCCGAGTTTCTGGCCCAGGAGAAACGAGGGGAGCATTTGAGCTGGCTCTGCATGTTTTGG
ATGATTGGTGGCGTGTACGCAGCTGCTATGGCCTGGGCCATCATCCCCCACTATGGGTGG
AGTTTTCAGATGGGTTCTGCCTACCAGTTCCACAGCTGGAGGGTCTTCGTCCTCGTCTGC
GCCTTTCCTTCTGTGTTTGCCATTGGGGCTCTGACCACGCAGCCTGAGAGCCCCCGTTTC
TTCCTAGAGAATGGAAAGCATGATGAGGCCTGGATGGTGCTGAAGCAGGTCCATGATACC
AACATGCGAGCCAAAGGACATCCTGAGCGAGTGTTCTCAGTAACCCACATTAAGACGATT
CATCAGGAGGATGAATTGATTGAGATCCAGTCGGACACAGGGACCTGGTACCAGCGCTGG
GGGGTCCGGGCCTTGAGCCTAGGGGGGCAGGTTTGGGGGAATTTTCTCTCCTGTTTTGGT
CCCGAATATCGGCGCATCACTCTGATGATGATGGGTGTGTGGTTCACCATGTCATTCAGC
TACTATGGCCTGACCGTCTGGTTTCCTGACATGATCCGCCATCTCCAGGCAGTGGACTAC
GCATCCCGCACCAAAGTGTTCCCCGGGGAGCGCGTAGAGCATGTAACTTTTAACTTCACG
TTGGAGAATCAGATCCACCGAGGCGGGCAGTACTTCAATGACAAGTTCATTGGGCTGCGG
CTCAAGTCAGTGTCCTTTGAGGATTCCCTGTTTGAAGAGTGTTATTTTGAGGATGTCACA
TCCAGCAACACGTTTTTCCGCAACTGCACATTCATCAACACTGTGTTCTATAACACTGAC
CTGTTCGAGTACAAGTTTGTGAACAGCCGTCTGATAAACAGTACATTCCTGCACAACAAG
GAGGGCTGCCCGCTAGACGTGACAGGGACGGGCGAAGGTGCCTACATGGTATACTTTGTG
AGCTTCCTGGGGACACTGGCAGTGCTTCCTGGGAATATCGTGTCTGCCCTGCTCATGGAC
AAGATCGGCAGGCTCAGAATGCTTGCTGGCTCCAGCGTGATGTCCTGTGTCTCCTGCTTC
TTCCTGTCTTTTGGGAACAGTGAGTCGGCCATGATCGCTCTGCTCTGCCTTTTTGGCGGG
GTCAGCATTGCATCCTGGAATGCGCTGGACGTGTTGACTGTTGAACTCTACCCCTCAGAC
AAGAGGACCACAGCTTTTGGCTTCCTGAATGCCCTGTGTAAGCTGGCAGCTGTGCTGGGG
ATCAGCATCTTCACATCCTTCGTGGGAATCACCAAGGCTGCACCCATCCTCTTTGCCTCA
GCTGCCCTTGCCCTTGGCAGCTCTCTGGCCCTGAAGCTGCCTGAGACCCGGGGGCAGGTG
CTGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 742 |
| Molecular Weight
| 82694.7 |
| Theoretical pI
| 5.26 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["170-190", "206-226", "234-254", "263-283", "295-315", "335-355", "448-468", "599-619", "627-647", "652-672", "686-708", "713-731"]
|
| Protein Sequence
|
>Synaptic vesicle glycoprotein 2A
MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPA
PSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLA
GVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADG
VEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLS
VNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFW
MIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRF
FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRW
GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDY
ASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVT
SSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFV
SFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGG
VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFAS
AALALGSSLALKLPETRGQVLQ
|
| External Links |
|---|
| GenBank ID Protein
| 216548223 |
| UniProtKB/Swiss-Prot ID
| Q7L0J3 |
| UniProtKB/Swiss-Prot Entry Name
| SV2A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014849.3 |
| GeneCard ID
| SV2A |
| GenAtlas ID
| SV2A |
| HGNC ID
| HGNC:20566 |
| References |
|---|
| General References
| Not Available |