| Identification |
|---|
| HMDB Protein ID
| CDBP03232 |
| Secondary Accession Numbers
| Not Available |
| Name
| Syntaxin-binding protein 5 |
| Description
| Not Available |
| Synonyms
|
- Lethal(2) giant larvae protein homolog 3
- Tomosyn-1
|
| Gene Name
| STXBP5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in vesicle-mediated transport |
| Specific Function
| Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Process |
| establishment of localization |
| transport |
| vesicle-mediated transport |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Peripheral membrane protein
- Peripheral membrane protein
- Cytoplasmic vesicle
- secretory vesicle
- Cell junction
- synapse
- Cytoplasmic vesicle membrane
- synaptic vesicle
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q24.3 |
| SNPs
| STXBP5 |
| Gene Sequence
|
>3456 bp
ATGAGGAAATTCAACATCAGGAAGGTGCTGGACGGCCTGACCGCCGGCTCGTCCTCGGCG
TCGCAGCAGCAACAGCAGCAGCATCCGCCTGGGAACCGGGAGCCGGAGATCCAGGAAACG
CTCCAGTCCGAGCACTTTCAGCTCTGCAAGACTGTTCGCCATGGATTTCCCTATCAACCC
TCAGCCCTGGCCTTTGATCCTGTACAGAAGATCCTGGCAGTGGGAACTCAGACTGGTGCT
TTAAGGCTCTTTGGTCGTCCAGGAGTAGAATGTTATTGCCAGCATGACAGTGGAGCTGCA
GTAATCCAGCTCCAGTTCCTGATTAATGAGGGAGCGCTTGTGAGTGCCTTGGCTGATGAC
ACCTTACACTTATGGAATTTACGTCAGAAGAGGCCTGCCATACTACATTCGCTTAAATTT
TGCAGAGAAAGGGTTACATTTTGCCATCTGCCTTTCCAGAGTAAGTGGCTCTATGTGGGC
ACTGAACGAGGTAATATACATATTGTCAATGTGGAGTCCTTCACACTCTCAGGCTACGTC
ATTATGTGGAATAAAGCCATTGAACTGTCATCTAAATCTCACCCAGGACCTGTGGTCCAT
ATAAGTGATAATCCAATGGACGAGGGAAAGCTTTTGATTGGCTTTGAATCTGGAACAGTA
GTTTTATGGGACCTCAAATCAAAGAAAGCCGACTACAGATACACATATGATGAGGCTATC
CACTCTGTTGCTTGGCATCATGAAGGAAAACAATTTATTTGCAGTCATTCAGATGGCACC
TTGACTATATGGAATGTAAGGTCCCCTGCTAAACCAGTACAGACAATCACTCCACATGGA
AAACAGTTAAAGGATGGGAAGAAGCCAGAACCATGCAAACCTATCCTCAAGGTGGAATTC
AAAACGACTAGATCTGGGGAGCCTTTTATTATTTTATCAGGAGGTTTGTCATATGATACT
GTAGGAAGAAGACCTTGCTTAACAGTGATGCATGGGAAAAGCACTGCTGTGCTAGAAATG
GACTATTCAATTGTTGATTTTCTAACGCTGTGTGAAACACCATACCCAAATGATTTTCAA
GAACCATATGCTGTGGTTGTTCTTCTAGAAAAGGATTTAGTACTTATAGACCTTGCACAA
AATGGATATCCTATATTTGAAAATCCCTACCCTTTGAGTATACATGAGTCCCCTGTTACA
TGTTGCGAATATTTTGCGGATTGTCCTGTGGACCTTATTCCTGCACTTTATTCTGTTGGA
GCTAGACAGAAACGTCAAGGTTACAGCAAAAAGGAATGGCCCATCAACGGAGGTAATTGG
GGCTTGGGTGCTCAAAGTTACCCAGAAATAATTATTACAGGGCATGCTGATGGGTCAGTT
AAGTTCTGGGATGCTTCTGCAATAACTCTACAAGTATTATATAAGCTAAAGACATCTAAA
GTATTTGAAAAGTCAAGAAATAAAGATGACAGGCCAAACACAGACATTGTAGATGAAGAT
CCATATGCCATTCAGATCATCTCCTGGTGTCCAGAAAGTAGAATGCTGTGCATCGCTGGA
GTTTCAGCTCATGTCATTATTTATAGATTCAGCAAGCAGGAAGTAATCACAGAAGTCATT
CCGATGCTTGAAGTTCGATTATTATATGAGATAAATGATGTGGAAACTCCGGAGGGTGAG
CAGCCACCACCTTTGCCAACACCCGTGGGAGGGTCCAACCCTCAGCCCATCCCTCCTCAG
TCTCATCCATCTACCAGTAGCAGTTCATCTGATGGGCTTCGTGATAATGTACCTTGTTTA
AAAGTTAAAAACTCACCACTTAAACAGTCTCCAGGTTATCAAACAGAACTAGTTATTCAG
TTGGTTTGGGTGGGTGGAGAACCACCACAACAAATAACCAGCCTGGCAGTCAATTCTTCC
TATGGACTGGTGGTTTTTGGCAATTGCAATGGCATTGCTATGGTTGACTACCTCCAGAAA
GCAGTGCTGCTCAACCTGGGCACTATTGAATTATATGGCTCTAATGATCCTTATCGGAGA
GAACCCCGATCTCCTCGTAAATCTCGACAGCCTTCAGGAGCCGGTCTGTGTGATATTAGT
GAAGGGACTGTTGTTCCAGAGGATCGCTGCAAATCTCCAACCTCTGGTTCTTCATCACCA
CACAATTCAGATGATGAACAAAAAATGAATAATTTTATAGAAAAGGTGAAGACCAAAAGC
AGAAAGTTTTCCAAGATGGTAGCCAATGATATAGCAAAGATGTCAAGGAAGTTAAGCTTA
CCTACTGACCTAAAGCCTGATTTAGATGTAAAGGATAACTCCTTTAGCCGATCACGGAGT
TCAAGTGTAACAAGCATTGACAAAGAATCCCGAGAAGCGATCTCCGCTCTTCATTTCTGT
GAAACGTTTACTCGAAAGACGGACTCGTCCCCTTCCCCTTGTCTATGGGTTGGAACAACG
CTAGGAACAGTGCTTGTCATTGCACTGAACCTTCCCCCAGGGGGAGAGCAAAGACTTCTT
CAGCCAGTAATTGTGTCTCCAAGTGGTACTATATTGAGGTTAAAAGGTGCAATCTTGAGA
ATGGCATTTCTGGATACCACAGGCTGCTTAATACCACCTGCGTATGAACCCTGGAGAGAG
CACAATGTTCCTGAAGAAAAAGACGAAAAGGAGAAATTGAAAAAACGGCGGCCTGTCTCA
GTATCCCCCTCCTCTTCTCAGGAAATTAGTGAAAACCAGTATGCAGTGATATGTTCTGAA
AAGCAAGCAAAAGTAATCTCACTGCCAACCCAGAACTGTGCTTATAAGCAAAATATTACA
GAGACCTCGTTTGTGCTTCGTGGAGATATTGTAGCATTGAGTAACAGTATCTGCCTTGCC
TGTTTCTGTGCCAATGGACATATAATGACTTTTAGTTTGCCAAGTTTAAGACCTCTGTTG
GATGTGTATTACTTGCCCCTTACCAATATGCGGATAGCCAGAACGTTCTGCTTTACCAAC
AATGGACAAGCATTATACCTTGTTTCACCTACAGAAATCCAGAGACTTACTTATAGTCAA
GAGACCTGTGAAAATCTTCAGGAAATGTTGGGTGAACTCTTCACTCCTGTAGAAACACCT
GAAGCACCAAACAGGGGATTCTTTAAAGGCTTATTTGGAGGTGGTGCACAATCTCTTGAC
AGAGAAGAACTATTTGGAGAATCGTCCTCAGGAAAGGCTTCAAGGAGCCTTGCACAGCAT
ATTCCTGGCCCTGGTGGCATTGAAGGCGTAAAAGGGGCAGCATCTGGAGTTGTTGGTGAA
TTAGCACGAGCCAGGCTGGCACTAGATGAAAGAGGGCAGAAACTTGGCGATCTGGAAGAA
AGAACTGCGGCCATGTTATCAAGTGCAGAGTCATTTTCTAAACATGCTCATGAGATTATG
TTGAAATACAAAGATAAGAAGTGGTACCAGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1151 |
| Molecular Weight
| 127571.5 |
| Theoretical pI
| 7.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Syntaxin-binding protein 5
MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQP
SALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADD
TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYV
IMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAI
HSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEF
KTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQ
EPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVG
ARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSK
VFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVI
PMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCL
KVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQK
AVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSGSSSP
HNSDDEQKMNNFIEKVKTKSRKFSKMVANDIAKMSRKLSLPTDLKPDLDVKDNSFSRSRS
SSVTSIDKESREAISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLL
QPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVS
VSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLA
CFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQ
ETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQH
IPGPGGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIM
LKYKDKKWYQF
|
| External Links |
|---|
| GenBank ID Protein
| 189217915 |
| UniProtKB/Swiss-Prot ID
| Q5T5C0 |
| UniProtKB/Swiss-Prot Entry Name
| STXB5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001127715.1 |
| GeneCard ID
| STXBP5 |
| GenAtlas ID
| STXBP5 |
| HGNC ID
| HGNC:19665 |
| References |
|---|
| General References
| Not Available |