| Identification |
|---|
| HMDB Protein ID
| CDBP03217 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sorcin |
| Description
| Not Available |
| Synonyms
|
- 22 kDa protein
- CP-22
- V19
|
| Gene Name
| SRI |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Cytoplasmic side
- Sarcoplasmic reticulum membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q21.1 |
| SNPs
| SRI |
| Gene Sequence
|
>597 bp
ATGGCGTACCCGGGGCATCCTGGCGCCGGCGGCGGGTACTACCCAGGCGGGTATGGAGGG
GCTCCCGGAGGGCCTGCGTTTCCCGGACAAACTCAGGATCCGCTGTATGGTTACTTTGCT
GCTGTAGCTGGACAGGATGGGCAGATAGATGCTGATGAATTGCAGAGATGTCTGACACAG
TCTGGCATTGCTGGAGGATACAAACCTTTTAACCTGGAGACTTGCCGGCTTATGGTTTCA
ATGCTGGATAGAGATATGTCTGGCACAATGGGTTTCAATGAATTTAAAGAACTCTGGGCT
GTACTGAATGGCTGGAGACAACACTTTATCAGTTTTGACACTGACAGGAGTGGAACAGTA
GACCCACAAGAATTGCAGAAGGCCCTGACAACAATGGGATTTAGGTTGAGTCCCCAGGCT
GTGAATTCAATTGCAAAACGATACAGCACCAATGGAAAGATCACCTTCGACGACTACATC
GCCTGCTGCGTCAAACTGAGGGCTCTTACAGACAGCTTTCGAAGACGGGATACTGCTCAG
CAAGGTGTTGTGAATTTCCCATATGATGATTTCATTCAATGTGTCATGAGTGTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 198 |
| Molecular Weight
| 21676.2 |
| Theoretical pI
| 5.21 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sorcin
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQ
SGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTV
DPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQ
QGVVNFPYDDFIQCVMSV
|
| External Links |
|---|
| GenBank ID Protein
| 15029636 |
| UniProtKB/Swiss-Prot ID
| P30626 |
| UniProtKB/Swiss-Prot Entry Name
| SORCN_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC011025 |
| GeneCard ID
| SRI |
| GenAtlas ID
| SRI |
| HGNC ID
| HGNC:11292 |
| References |
|---|
| General References
| Not Available |