| Identification |
|---|
| HMDB Protein ID
| CDBP03214 |
| Secondary Accession Numbers
| Not Available |
| Name
| SRC kinase signaling inhibitor 1 |
| Description
| Not Available |
| Synonyms
|
- SNAP-25-interacting protein
- SNIP
- p130Cas-associated protein
- p140Cap
|
| Gene Name
| SRCIN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase binding |
| Specific Function
| Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm
- cytoskeleton
- Cell junction
- Cell junction
- synapse
- synapse
- Cell projection
- Cell projection
- postsynaptic cell membrane
- postsynaptic density
- dendrite
- axon
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q12 |
| SNPs
| SRCIN1 |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 1055 |
| Molecular Weight
| 112452.4 |
| Theoretical pI
| 9.82 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>SRC kinase signaling inhibitor 1
MRGAWVHLHSGAASSLRPCRCGAGAAPKSSPRSPGGRRGDGSSDSEGGVSFAGVLFLQFG
EETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRD
IQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSP
PPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAI
LERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYK
RGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGP
PPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPG
ERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAA
TPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQL
QQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEEL
ITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMR
VVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKV
TAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSV
EAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPK
APHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVV
VTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAE
LESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMS
GSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF
|
| External Links |
|---|
| GenBank ID Protein
| 115334682 |
| UniProtKB/Swiss-Prot ID
| Q9C0H9 |
| UniProtKB/Swiss-Prot Entry Name
| SRCN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| SRCIN1 |
| GenAtlas ID
| SRCIN1 |
| HGNC ID
| HGNC:29506 |
| References |
|---|
| General References
| Not Available |