| Identification |
|---|
| HMDB Protein ID
| CDBP03213 |
| Secondary Accession Numbers
| Not Available |
| Name
| SNARE-associated protein Snapin |
| Description
| Not Available |
| Synonyms
|
- SNAP-associated protein
- Synaptosomal-associated protein 25-binding protein
|
| Gene Name
| SNAPIN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in SNARE binding |
| Specific Function
| May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the SNAREs and the plasma- membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Peripheral membrane protein
- Peripheral membrane protein
- Cytoplasmic vesicle
- Membrane
- Cytoplasmic side
- Cytoplasmic side
- secretory vesicle
- Cytoplasmic side (Potential)
- Cell junction
- synapse
- Cytoplasmic vesicle membrane
- synaptosome
- synaptic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21.3 |
| SNPs
| SNAPIN |
| Gene Sequence
|
>411 bp
ATGGCGGGGGCTGGTTCCGCCGCTGTATCGGGGGCAGGGACCCCGGTGGCGGGGCCCACA
GGCCGCGACCTTTTCGCCGAAGGGCTGCTGGAGTTCCTGCGACCCGCTGTGCAGCAGCTC
GACTCTCACGTACACGCCGTCAGAGAGAGCCAGGTAGAGCTCCGGGAACAAATTGACAAC
CTAGCCACAGAACTGTGCCGCATAAATGAGGATCAGAAGGTGGCCCTGGATCTTGACCCC
TATGTTAAGAAGCTACTTAATGCCCGGCGACGCGTTGTCTTGGTTAACAACATTCTACAG
AATGCTCAGGAACGACTGAGACGGCTAAACCACAGTGTTGCCAAGGAAACAGCCCGCAGG
AGAGCAATGCTGGATTCGGGAATTTACCCCCCTGGCTCCCCAGGCAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 136 |
| Molecular Weight
| 14873.8 |
| Theoretical pI
| 9.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>SNARE-associated protein Snapin
MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDN
LATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARR
RAMLDSGIYPPGSPGK
|
| External Links |
|---|
| GenBank ID Protein
| 4206088 |
| UniProtKB/Swiss-Prot ID
| O95295 |
| UniProtKB/Swiss-Prot Entry Name
| SNAPN_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF086837 |
| GeneCard ID
| SNAPIN |
| GenAtlas ID
| SNAPIN |
| HGNC ID
| HGNC:17145 |
| References |
|---|
| General References
| Not Available |