Showing Protein Pulmonary surfactant-associated protein A1 (CDBP03211)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03211
Secondary Accession Numbers Not Available
Name Pulmonary surfactant-associated protein A1
Description Not Available
Synonyms
  1. 35 kDa pulmonary surfactant-associated protein
  2. Alveolar proteinosis protein
  3. Collectin-4
  4. PSP-A
  5. PSPA
  6. SP-A
  7. SP-A1
Gene Name SFTPA1
Protein Type Enzyme
Biological Properties
General Function Involved in binding
Specific Function In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration
GO Classification
Function
binding
Cellular Location
  1. Secreted
  2. Secreted
  3. extracellular space
  4. extracellular space
  5. extracellular matrix
  6. surface film
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 10q22.3
SNPs SFTPA1
Gene Sequence 
>747 bp
ATGTGGCTGTGCCCTCTGGCCCTCAACCTCATCTTGATGGCAGCCTCTGGTGCTGTGTGC
GAAGTGAAGGACGTTTGTGTTGGAAGCCCTGGTATCCCCGGCACTCCTGGATCCCACGGC
CTGCCAGGCAGGGACGGGAGAGATGGTCTCAAAGGAGACCCTGGTCCTCCAGGCCCCATG
GGTCCACCTGGAGAAATGCCATGTCCTCCTGGAAATGATGGGCTGCCTGGAGCCCCTGGT
ATCCCTGGAGAGTGTGGAGAGAAGGGGGAGCCTGGCGAGAGGGGCCCTCCAGGGCTTCCA
GCTCATCTAGATGAGGAGCTCCAAGCCACACTCCACGACTTTAGACATCAAATCCTGCAG
ACAAGGGGAGCCCTCAGTCTGCAGGGCTCCATAATGACAGTAGGAGAGAAGGTCTTCTCC
AGCAATGGGCAGTCCATCACTTTTGATGCCATTCAGGAGGCATGTGCCAGAGCAGGCGGC
CGCATTGCTGTCCCAAGGAATCCAGAGGAAAATGAGGCCATTGCAAGCTTCGTGAAGAAG
TACAACACATATGCCTATGTAGGCCTGACTGAGGGTCCCAGCCCTGGAGACTTCCGCTAC
TCAGACGGGACCCCTGTAAACTACACCAACTGGTACCGAGGGGAGCCCGCAGGTCGGGGA
AAAGAGCAGTGTGTGGAGATGTACACAGATGGGCAGTGGAATGACAGGAACTGCCTGTAC
TCCCGACTGACCATCTGTGAGTTCTGA
Protein Properties
Number of Residues 248
Molecular Weight 26242.3
Theoretical pI 4.63
Pfam Domain Function
Signals
  • ["1-20"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Pulmonary surfactant-associated protein A1
MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPM
GPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQ
TRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKK
YNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLY
SRLTICEF
GenBank ID Protein 158254842
UniProtKB/Swiss-Prot ID Q8IWL2
UniProtKB/Swiss-Prot Entry Name SFTA1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK290703
GeneCard ID SFTPA1
GenAtlas ID SFTPA1
HGNC ID HGNC:10798
References
General References Not Available