| Identification |
|---|
| HMDB Protein ID
| CDBP03191 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein S100-B |
| Description
| Not Available |
| Synonyms
|
- S-100 protein beta chain
- S-100 protein subunit beta
- S100 calcium-binding protein B
|
| Gene Name
| S100B |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 21q22.3 |
| SNPs
| S100B |
| Gene Sequence
|
>279 bp
ATGTCTGAGCTGGAGAAGGCCATGGTGGCCCTCATCGACGTTTTCCACCAATATTCTGGA
AGGGAGGGAGACAAGCACAAGCTGAAGAAATCCGAACTGAAGGAGCTCATCAACAATGAG
CTTTCCCATTTCTTAGAGGAAATCAAAGAGCAGGAGGTTGTGGACAAAGTCATGGAAACA
CTGGACAATGATGGAGACGGCGAATGTGACTTCCAGGAATTCATGGCCTTTGTTGCCATG
GTTACTACTGCCTGCCACGAGTTCTTTGAACATGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 92 |
| Molecular Weight
| 10713.0 |
| Theoretical pI
| 4.25 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein S100-B
MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMET
LDNDGDGECDFQEFMAFVAMVTTACHEFFEHE
|
| External Links |
|---|
| GenBank ID Protein
| 5454034 |
| UniProtKB/Swiss-Prot ID
| P04271 |
| UniProtKB/Swiss-Prot Entry Name
| S100B_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_006272.2 |
| GeneCard ID
| S100B |
| GenAtlas ID
| S100B |
| HGNC ID
| HGNC:10500 |
| References |
|---|
| General References
| Not Available |