| Identification |
|---|
| HMDB Protein ID
| CDBP03182 |
| Secondary Accession Numbers
| Not Available |
| Name
| GTP-binding protein REM 1 |
| Description
| Not Available |
| Synonyms
|
- GTPase-regulating endothelial cell sprouting
- Rad and Gem-like GTP-binding protein 1
|
| Gene Name
| REM1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| nucleoside-triphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| pyrophosphatase activity |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| gtpase activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q11.21 |
| SNPs
| REM1 |
| Gene Sequence
|
>897 bp
ATGACACTCAACACCGAGCAGGAAGCAAAGACCCCTCTGCACCGGCGAGCCAGCACCCCA
CTGCCCCTGTCCCCACGGGGCCACCAGCCTGGCCGCCTGAGCACAGTGCCTTCCACTCAA
TCCCAGCATCCCCGGCTGGGCCAATCAGCCTCCCTCAACCCTCCCACCCAGAAACCTTCA
CCTGCCCCAGATGATTGGTCTTCTGAATCCAGCGACTCTGAAGGCTCCTGGGAGGCTCTC
TACCGTGTGGTGCTACTTGGAGATCCTGGAGTGGGGAAGACCAGCTTGGCCAGCCTCTTT
GCAGGGAAGCAAGAGAGGGACCTCCATGAACAGCTGGGAGAAGATGTATATGAGAGGACC
CTCACGGTGGATGGAGAAGACACCACACTGGTGGTCGTGGACACCTGGGAGGCCGAGAAA
CTGGATAAAAGCTGGAGCCAGGAGTCATGCCTGCAGGGGGGCAGTGCCTATGTCATCGTA
TACTCCATCGCAGACCGAGGCAGCTTTGAGAGTGCCTCTGAGCTCCGCATCCAGCTGCGG
CGCACACATCAGGCAGACCATGTGCCCATCATCCTCGTGGGCAACAAGGCAGACTTGGCC
CGCTGCCGAGAAGTCTCTGTGGAAGTGGGCCGCGCCTGCGCTGTGGTGTTCGACTGTAAA
TTCATCGAGACATCCGCCACGCTGCAGCACAATGTGGCCGAGCTCTTCGAGGGCGTGGTG
CGCCAACTGCGCTTGCGCCGCCGGGACAGTGCGGCCAAGGAACCCCCAGCACCCCGACGG
CCGGCCAGCCTAGCCCAGCGCGCTCGTCGCTTCCTGGCACGCCTGACAGCCCGCAGCGCA
CGCCGCCGGGCACTCAAGGCCCGCTCCAAGTCCTGCCACAATCTGGCCGTGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 298 |
| Molecular Weight
| 32946.7 |
| Theoretical pI
| 9.01 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>GTP-binding protein REM 1
MTLNTEQEAKTPLHRRASTPLPLSPRGHQPGRLSTVPSTQSQHPRLGQSASLNPPTQKPS
PAPDDWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAGKQERDLHEQLGEDVYERT
LTVDGEDTTLVVVDTWEAEKLDKSWSQESCLQGGSAYVIVYSIADRGSFESASELRIQLR
RTHQADHVPIILVGNKADLARCREVSVEEGRACAVVFDCKFIETSATLQHNVAELFEGVV
RQLRLRRRDSAAKEPPAPRRPASLAQRARRFLARLTARSARRRALKARSKSCHNLAVL
|
| External Links |
|---|
| GenBank ID Protein
| 3462896 |
| UniProtKB/Swiss-Prot ID
| O75628 |
| UniProtKB/Swiss-Prot Entry Name
| REM1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF084465 |
| GeneCard ID
| REM1 |
| GenAtlas ID
| REM1 |
| HGNC ID
| HGNC:15922 |
| References |
|---|
| General References
| Not Available |