| Identification |
|---|
| HMDB Protein ID
| CDBP03168 |
| Secondary Accession Numbers
| Not Available |
| Name
| Bone marrow proteoglycan |
| Description
| Not Available |
| Synonyms
|
- BMPG
- EMBP
- Eosinophil granule major basic protein
- MBP
- Pregnancy-associated major basic protein
- Proteoglycan 2
|
| Gene Name
| PRG2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA |
| GO Classification
|
| Function |
| binding |
| Process |
| immune system process |
| immune response |
|
| Cellular Location
|
- secretory vesicle
- Eosinophil granule major basic protein:Cytoplasmic vesicle
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q12 |
| SNPs
| PRG2 |
| Gene Sequence
|
>669 bp
ATGAAACTCCCCCTACTTCTGGCTCTTCTATTTGGGGCAGTTTCTGCTCTTCATCTAAGG
TCTGAGACTTCCACCTTTGAGACCCCTTTGGGTGCTAAGACGCTGCCTGAGGATGAGGAG
ACACCAGAGCAGGAGATGGAGGAGACCCCTTGCAGGGAGCTGGAGGAAGAGGAGGAGTGG
GGCTCTGGAAGTGAAGATGCCTCCAAGAAAGATGGGGCTGTTGAGTCTATCTCAGTGCCA
GATATGGTGGACAAAAACCTTACGTGTCCTGAGGAAGAGGACACAGTAAAAGTGGTGGGC
ATCCCTGGGTGCCAGACCTGCCGCTACCTCCTGGTGAGAAGTCTTCAGACGTTTAGTCAA
GCTTGGTTTACTTGCCGGAGGTGCTACAGGGGCAACCTGGTTTCCATCCACAACTTCAAT
ATTAATTATCGAATCCAGTGTTCTGTCAGCGCGCTCAACCAGGGTCAAGTCTGGATTGGA
GGCAGGATCACAGGCTCGGGTCGCTGCAGACGCTTTCAGTGGGTTGACGGCAGCCGCTGG
AACTTTGCGTACTGGGCTGCTCACCAGCCCTGGTCCCGCGGTGGTCACTGCGTGGCCCTG
TGTACCCGAGGAGGCTACTGGCGTCGAGCCCACTGCCTCAGAAGACTTCCTTTCATCTGT
TCCTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 222 |
| Molecular Weight
| 25205.3 |
| Theoretical pI
| 6.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Bone marrow proteoglycan
MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEW
GSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQ
AWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRW
NFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY
|
| External Links |
|---|
| GenBank ID Protein
| 34476 |
| UniProtKB/Swiss-Prot ID
| P13727 |
| UniProtKB/Swiss-Prot Entry Name
| PRG2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Y00809 |
| GeneCard ID
| PRG2 |
| GenAtlas ID
| PRG2 |
| HGNC ID
| HGNC:9362 |
| References |
|---|
| General References
| Not Available |