| Identification |
|---|
| HMDB Protein ID
| CDBP03167 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein phosphatase 1 regulatory subunit 1A |
| Description
| Not Available |
| Synonyms
|
- I-1
- IPP-1
- Protein phosphatase inhibitor 1
|
| Gene Name
| PPP1R1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphoprotein phosphatase inhibitor activity |
| Specific Function
| Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases |
| GO Classification
|
| Function |
| enzyme regulator activity |
| enzyme inhibitor activity |
| phosphatase inhibitor activity |
| phosphoprotein phosphatase inhibitor activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q13.2 |
| SNPs
| PPP1R1A |
| Gene Sequence
|
>516 bp
ATGGAGCAAGACAACAGCCCCCGAAAGATCCAGTTCACGGTCCCGCTGCTGGAGCCGCAC
CTTGACCCCGAGGCGGCGGAGCAGATTCGGAGGCGCCGCCCCACCCCTGCCACCCTCGTG
CTGACCGGTGACCAGTCATCCCCAGAGATAGATGAAGACCGGATCCCCAACCCACATCTC
AAGTCCACTTTGGCAATGTCTCCACGGCAACGGAAGAAGATGACAAGGATCACACCCACA
ATGAAAGAGCTCCAGATGATGGTTGAACATCACCTGGGGCAACAGCAGCAAGGAGAGGAA
CCTGAGGGGGCCGCTGAGAGCACAGGAACCCAGGAGTCCCGCCCACCTGGGATCCCAGAC
ACAGAAGTGGAGTCAAGGCTGGGCACCTCTGGGACAGCAAAAAAAACTGCAGAATGCATC
CCTAAAACTCATGAAAGAGGCAGTAAGGAACCCAGCACAAAAGAACCCTCAACCCATATA
CCACCACTGGATTCCAAGGGAGCTAACTCGGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 171 |
| Molecular Weight
| 19011.2 |
| Theoretical pI
| 6.25 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein phosphatase 1 regulatory subunit 1A
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHL
KSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTETQESRPPGIPD
TEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV
|
| External Links |
|---|
| GenBank ID Protein
| 17978643 |
| UniProtKB/Swiss-Prot ID
| Q13522 |
| UniProtKB/Swiss-Prot Entry Name
| PPR1A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY063766 |
| GeneCard ID
| PPP1R1A |
| GenAtlas ID
| PPP1R1A |
| HGNC ID
| HGNC:9286 |
| References |
|---|
| General References
| Not Available |